Clint Miller
@clintomics.bsky.social
Human genomicist, Assoc Prof @UVA. Deconvolving complex cardiovascular diseases using systems genetics and single-cell omics.
Latest news feature in @natbiotech.nature.com on recent developments in spatial biology to unravel disease mechanisms, with insights from experts in field. @aruthak.bsky.social @nebanovich.bsky.social @ai4pathology.bsky.social @jasmineplummer.bsky.social www.nature.com/articles/s41...
Beyond cell atlases: spatial biology reveals mechanisms behind disease - Nature Biotechnology
As the next generation of spatial transcriptomics tools hits the market, researchers are uncovering previously unknown interactions that could transform clinical research.
www.nature.com
May 21, 2025 at 12:51 PM
Latest news feature in @natbiotech.nature.com on recent developments in spatial biology to unravel disease mechanisms, with insights from experts in field. @aruthak.bsky.social @nebanovich.bsky.social @ai4pathology.bsky.social @jasmineplummer.bsky.social www.nature.com/articles/s41...
Reposted by Clint Miller
Thrilled to share the🥇paper from the lab @ahajournals.bsky.social. Here we continue to unravel the mysteries of the 9p21.3 CAD locus showing it drives VSMC transition into an osteochondrogenic state, promoting calcification. @clintomics.bsky.social @UWMadison CRB.
www.ahajournals.org/doi/10.1161/...
www.ahajournals.org/doi/10.1161/...
9p21.3 Coronary Artery Disease Risk Locus Drives Vascular Smooth Muscle Cells to an Osteochondrogenic State | Arteriosclerosis, Thrombosis, and Vascular Biology
BACKGROUND: Genome-wide association studies have identified common genetic variants at ≈300 human
genomic loci linked to coronary artery disease susceptibility. Among these genomic
regions, the most i...
www.ahajournals.org
March 30, 2025 at 8:15 PM
Thrilled to share the🥇paper from the lab @ahajournals.bsky.social. Here we continue to unravel the mysteries of the 9p21.3 CAD locus showing it drives VSMC transition into an osteochondrogenic state, promoting calcification. @clintomics.bsky.social @UWMadison CRB.
www.ahajournals.org/doi/10.1161/...
www.ahajournals.org/doi/10.1161/...
Reposted by Clint Miller
Did we tell you about this news?
www.vanderlaanscience.nl/news/care-t1d
Glad for the support to be able to collaborate with @clintomics.bsky.social Suna Onengut-Gumuscu and @metecivelek.bsky.social from #UVA.
www.vanderlaanscience.nl/news/care-t1d
Glad for the support to be able to collaborate with @clintomics.bsky.social Suna Onengut-Gumuscu and @metecivelek.bsky.social from #UVA.
Unraveling the Heart of Type 1 Diabetes — Van der Laan & Science
Unraveling the Heart of Type 1 Diabetes: on our U01 grant to study the immune-link between type 1 diabetes, type 2 diabetes and cardiovascular disease.
www.vanderlaanscience.nl
March 14, 2025 at 3:48 PM
Did we tell you about this news?
www.vanderlaanscience.nl/news/care-t1d
Glad for the support to be able to collaborate with @clintomics.bsky.social Suna Onengut-Gumuscu and @metecivelek.bsky.social from #UVA.
www.vanderlaanscience.nl/news/care-t1d
Glad for the support to be able to collaborate with @clintomics.bsky.social Suna Onengut-Gumuscu and @metecivelek.bsky.social from #UVA.
Excited to finally share our work on attention-based multiple instance learning to quantify and characterize intraplaque haemorrhage in carotid plaque whole slide images from >2500 patients in AtheroExpress. Fun collaboration with @swvanderlaan.bsky.social and Craig Glastonbury labs.
🚀 Thrilled to announce our latest #preprint on intraplaque haemorrhage (IPH) quantification and molecular 🧬characterisation of carotid plaques using deep learning. A thread 🧵👇🏽
March 7, 2025 at 8:27 PM
Excited to finally share our work on attention-based multiple instance learning to quantify and characterize intraplaque haemorrhage in carotid plaque whole slide images from >2500 patients in AtheroExpress. Fun collaboration with @swvanderlaan.bsky.social and Craig Glastonbury labs.
Reposted by Clint Miller
Preliminary injunction in nationwide indirect cost rate case.
This means that the judge found that the plaintiffs (AAMC, et al.) are likely to win on the merits when the ruling is finalized.
www.statnews.com/2025/03/05/n...
This means that the judge found that the plaintiffs (AAMC, et al.) are likely to win on the merits when the ruling is finalized.
www.statnews.com/2025/03/05/n...
Judge issues preliminary injunction blocking Trump cuts to NIH research overhead payments
A federal judge issued a nationwide preliminary injunction blocking the Trump administration from slashing NIH payments for research overhead
www.statnews.com
March 5, 2025 at 9:08 PM
Preliminary injunction in nationwide indirect cost rate case.
This means that the judge found that the plaintiffs (AAMC, et al.) are likely to win on the merits when the ruling is finalized.
www.statnews.com/2025/03/05/n...
This means that the judge found that the plaintiffs (AAMC, et al.) are likely to win on the merits when the ruling is finalized.
www.statnews.com/2025/03/05/n...
NIH slashes overhead payments for research, sparking outrage www.science.org/content/arti...
NIH slashes overhead payments for research, sparking outrage
Move to cut indirect cost rate to 15% could cost universities billions of dollars
www.science.org
February 8, 2025 at 3:30 AM
NIH slashes overhead payments for research, sparking outrage www.science.org/content/arti...
Reposted by Clint Miller
On changes to #NIH indirect rates, there is a law in place that prohibits NIH from making such changes without the approval of Congress. See Division D, Title II Section 224 of The Further Consolidated Appropriations Act, 2024 (Public Law No: 118-47) grants.nih.gov/grants/guide...
NOT-OD-24-110: Notice of Legislative Mandates in Effect for FY 2024
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Legislative Mandates in Effect for FY 2024 NOT-OD-24-110. NIH
grants.nih.gov
February 8, 2025 at 12:56 AM
On changes to #NIH indirect rates, there is a law in place that prohibits NIH from making such changes without the approval of Congress. See Division D, Title II Section 224 of The Further Consolidated Appropriations Act, 2024 (Public Law No: 118-47) grants.nih.gov/grants/guide...
Reposted by Clint Miller
Academic Skyers: I am compiling a list of policies and statements from various universities about how they are handling the "pause" in terms of stopping expenditures (or not).
Please respond to this post with your institution and materials.
THANK YOU!
Please respond to this post with your institution and materials.
THANK YOU!
January 28, 2025 at 5:35 PM
Academic Skyers: I am compiling a list of policies and statements from various universities about how they are handling the "pause" in terms of stopping expenditures (or not).
Please respond to this post with your institution and materials.
THANK YOU!
Please respond to this post with your institution and materials.
THANK YOU!
Reposted by Clint Miller
Modern GWAS can identify 1000s of significant hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease?
I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵
I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵
January 26, 2025 at 12:13 AM
Modern GWAS can identify 1000s of significant hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease?
I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵
I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵
New single-cell analysis framework, LEMUR, disentangles covariates and latent cell states from multi-condition data to predict counterfactual gene expression and identify cell neighborhoods with similar DEGs without clustering. doi.org/10.1038/s415... @naturegenet.bsky.social
January 3, 2025 at 5:34 PM
New single-cell analysis framework, LEMUR, disentangles covariates and latent cell states from multi-condition data to predict counterfactual gene expression and identify cell neighborhoods with similar DEGs without clustering. doi.org/10.1038/s415... @naturegenet.bsky.social
Delineating the effective use of self-supervised learning in single-cell genomics www.nature.com/articles/s42... @fabiantheis.bsky.social
Delineating the effective use of self-supervised learning in single-cell genomics - Nature Machine Intelligence
Self-supervised learning techniques are powerful assets for enabling deep insights into complex, unlabelled single-cell genomic data. Richter et al. here benchmark the applicability of self-supervised...
www.nature.com
December 28, 2024 at 4:25 PM
Delineating the effective use of self-supervised learning in single-cell genomics www.nature.com/articles/s42... @fabiantheis.bsky.social
Very grateful and humbled to receive promotion to tenure at UVA School of Medicine.
Huge thanks to my supportive mentors, colleagues, family, and talented trainees who continue to inspire me along this journey.
Here’s to the work ahead!
Huge thanks to my supportive mentors, colleagues, family, and talented trainees who continue to inspire me along this journey.
Here’s to the work ahead!
December 18, 2024 at 1:20 AM
Very grateful and humbled to receive promotion to tenure at UVA School of Medicine.
Huge thanks to my supportive mentors, colleagues, family, and talented trainees who continue to inspire me along this journey.
Here’s to the work ahead!
Huge thanks to my supportive mentors, colleagues, family, and talented trainees who continue to inspire me along this journey.
Here’s to the work ahead!
New method CellANOVA recovers lost biological signals and evaluates global and gene level distortions introduced from common single-cell batch correction algorithms github.com/Janezjz/cell... www.nature.com/articles/s41...
Recovery of biological signals lost in single-cell batch integration with CellANOVA - Nature Biotechnology
A statistical framework quantifies single-cell batch variation and recovers meaningful biological signals.
www.nature.com
November 26, 2024 at 2:24 PM
New method CellANOVA recovers lost biological signals and evaluates global and gene level distortions introduced from common single-cell batch correction algorithms github.com/Janezjz/cell... www.nature.com/articles/s41...