Clément Cochain
@clementcochain.bsky.social
Biologist interested in inflammation in cardiovascular diseases at the Paris Cardiovascular Research Center 🇫🇷 & University Hospital Würzburg 🇩🇪. Personal account, views my own.
Reposted by Clément Cochain
P Breillat and B Terrier from PL Tharaux team @PARCC showed that NK-cell dysfunction in VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome contributes to increased susceptibility to severe infections.
doi.org/10.1182/bloo...
doi.org/10.1182/bloo...
Impaired cytotoxic function and exhausted phenotype of natural killer cells in VEXAS syndrome
Key PointsNK-cell phenotyping reveals impaired cytotoxicity, chronic activation, and exhaustion in VEXAS syndrome.Decreased circulating NK cells were indep
doi.org
October 22, 2025 at 4:02 PM
P Breillat and B Terrier from PL Tharaux team @PARCC showed that NK-cell dysfunction in VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome contributes to increased susceptibility to severe infections.
doi.org/10.1182/bloo...
doi.org/10.1182/bloo...
Reposted by Clément Cochain
Pr JS Hulot team @PARCC revealed that CD51 contributes to the immune-fibrotic axis driving heart failure progression under pressure overload.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Inhibition of integrin alpha V reduces inflammation and the transition to heart failure after pressure overload
Integrin alpha V (CD51) is a surface receptor that binds to extracellular matrix ligands and contributes to fibrotic responses, including post-infarct…
www.sciencedirect.com
October 6, 2025 at 4:36 PM
Pr JS Hulot team @PARCC revealed that CD51 contributes to the immune-fibrotic axis driving heart failure progression under pressure overload.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Clément Cochain
Mouse and human macrophages and their roles in cardiovascular health and disease
Alexandre Gallerand, Jichang Han, Stoyan Ivanov & Gwendalyn J. Randolph
Nature Cardiovascular Research (2024)
www.nature.com/articles/s44...
Alexandre Gallerand, Jichang Han, Stoyan Ivanov & Gwendalyn J. Randolph
Nature Cardiovascular Research (2024)
www.nature.com/articles/s44...
Mouse and human macrophages and their roles in cardiovascular health and disease - Nature Cardiovascular Research
Gallerand et al. review the main human and murine macrophage populations, highlighting their phenotypic and functional diversity and how they contribute to cardiovascular health by regulating the infl...
www.nature.com
November 27, 2024 at 10:32 AM
Mouse and human macrophages and their roles in cardiovascular health and disease
Alexandre Gallerand, Jichang Han, Stoyan Ivanov & Gwendalyn J. Randolph
Nature Cardiovascular Research (2024)
www.nature.com/articles/s44...
Alexandre Gallerand, Jichang Han, Stoyan Ivanov & Gwendalyn J. Randolph
Nature Cardiovascular Research (2024)
www.nature.com/articles/s44...
Reposted by Clément Cochain
Hiring! I'm looking for a postdoc in machine learning of spatial single-cell data. Exciting project to develop methods for modelling cellular circuits in disease and regeneration of heart, liver and bone marrow using Xenium data from our lab.
tinyurl.com/ymkvk7vn
tinyurl.com/ymkvk7vn
November 20, 2024 at 8:07 AM
Hiring! I'm looking for a postdoc in machine learning of spatial single-cell data. Exciting project to develop methods for modelling cellular circuits in disease and regeneration of heart, liver and bone marrow using Xenium data from our lab.
tinyurl.com/ymkvk7vn
tinyurl.com/ymkvk7vn
Reposted by Clément Cochain
We are seeking a motivated PhD student to join our research group in Würzburg 🇩🇪! Explore fundamental mechanisms of #megakaryocyte development in a collaborative environment #WürzburgPlateletGroup #Phosphorylation #PhDPosition
Know someone who might be interested?
karriere.ukw.de/en/p/wissens...
Know someone who might be interested?
karriere.ukw.de/en/p/wissens...
November 20, 2024 at 11:52 AM
We are seeking a motivated PhD student to join our research group in Würzburg 🇩🇪! Explore fundamental mechanisms of #megakaryocyte development in a collaborative environment #WürzburgPlateletGroup #Phosphorylation #PhDPosition
Know someone who might be interested?
karriere.ukw.de/en/p/wissens...
Know someone who might be interested?
karriere.ukw.de/en/p/wissens...
Lots of interesting findings in this new paper, including atherosclerotic plaque stabilization induced by the TREM2 agonist antibody 4D9 in a mouse model of atherosclerosis aggravated by clonal hematopoiesis
www.jci.org/articles/vie...
www.jci.org/articles/vie...
November 18, 2024 at 8:35 AM
Lots of interesting findings in this new paper, including atherosclerotic plaque stabilization induced by the TREM2 agonist antibody 4D9 in a mouse model of atherosclerosis aggravated by clonal hematopoiesis
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Reposted by Clément Cochain
Excited to share our study on spatio-temporal reconstruction of cardiac scar formation led by Andy Chan. We combine scRNA-seq with spatial transcriptomics to resolve the fibrotic niche and the niche of dedifferentiating cardiomyocytes.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 16, 2024 at 12:26 PM
Excited to share our study on spatio-temporal reconstruction of cardiac scar formation led by Andy Chan. We combine scRNA-seq with spatial transcriptomics to resolve the fibrotic niche and the niche of dedifferentiating cardiomyocytes.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...