18/ At large genomic distance, long encounters (=the important ones) are only due to loop extrusion; but at short genomic distance they can also be due to random collisions. This is why enhancers are no sensitive to loss of extrusion when they are close, but sensitive when they are far!

We need a genbank database

We hope that people find these ideas interesting, and that they maybe even provide new hypotheses to test experimentally. Thanks to Omer Gilan and @faulknerlab.bsky.social for help exploring these ideas over the last 5-6 years.

One of the main goals of this review was to help clarify some of the confusion in the field about "epigenetics", specifically the interplay between TFs and histone mods. Here, we attempt to unify the role of transcription factors and histone modifications under a single conceptual framework.

Chromatin memory has been appreciated for a long time, but we believe its implications have not been fully explored. The capacity for local, chromatin memory to stabilise non-encoded cell states has major implications for the evolution of cell types and formation of resistant cell states in cancer.