This suggests that these traits are intrinsic to certain plasmid families, independent of the antibiotic resistance context.

I' am particularly happy with this figure, which (nicely?) summarizes the mobility and host-range profiles of major AMR-associated plasmid families

These traits likely explain their key role in spreading AMR : ARGs often come from distantly related bacteria and spread rapidly.

Interestingly, when we removed plasmids carrying ARGs and repeated the analysis, families often associated with ARGs were still more plastic and more mobile.

We found ARGs strongly associate with plasmid families that are:

- Highly mobile (autonomous conjugation)
- Broad host range (transferring genes across distant bacterial species)
- Highly plastic (frequently exchanging genes)