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Reposted by Cedric Boeckx

Valerie Jill Sydnor @valeriejsydnor.bsky.social · 13h

Happy to share our review "Investigating hierarchical critical periods in human neurodevelopment” in @npp-journal.bsky.social! We examine neurobiological, environmental & behavioral evidence for human critical periods in sensory and association cortex +discuss new research directions rdcu.be/eMkVU 🧵

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Cedric Boeckx @cedricboeckx.bsky.social · 14h

Thanks for organizing this talk, @radicalanthro.bsky.social. Always fascinating to listen to @chrisbstringer.bsky.social & think about the complexities Chris touched on in his talk

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Cedric Boeckx @cedricboeckx.bsky.social · 14h

Nice work @hannahmm.bsky.social (sorry I missed your handle earlier)

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Reposted by Cedric Boeckx

Omer Ali Bayraktar @bayraktarlab.bsky.social · 23h

Which human brain circuits are implicated in neurodevelopmental conditions? We bridged human genetics, spatial transcriptomics and neurodevelopment to discover the convergence of autism-associated genes in the developing human thalamus! www.biorxiv.org/content/10.1...

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Cedric Boeckx @cedricboeckx.bsky.social · 20h

@animal-prattle.bsky.social could be of interest

Cedric Boeckx @cedricboeckx.bsky.social · 20h

Always happy to see researchers like A. Leblois, going beyond the classical birdsong circuit & looking at the #cerebellum to give it its due: “A lobule-specific neuronal representation of song temporal structure in the songbird cerebellum” 🧪🐦🎵🧠
www.biorxiv.org/content/10.1...

A lobule-specific neuronal representation of song temporal structure in the songbird cerebellum

The cerebellum is involved in the acquisition and production of speech as revealed by clinical evidence and imaging studies, but its specific role however remains unclear. Songbirds provide a unique m...

www.biorxiv.org

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Cedric Boeckx @cedricboeckx.bsky.social · 20h

New preprint by Hannah Munby and @mollyprz.bsky.social:
“Revisiting the evidence for long-lived balancing selection in humans” 🧪🧬
www.biorxiv.org/content/10.1...

Revisiting the evidence for long-lived balancing selection in humans.

Balancing selection maintains variation in a population longer than expected under neutrality. In humans, there are dozens of tentative candidate loci for balancing selection, but only a handful of we...

www.biorxiv.org

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Cedric Boeckx @cedricboeckx.bsky.social · 1d

Congrats to first-authors @kirstyuttley.bsky.social & @hannahjuellig.bsky.social 👏

Cedric Boeckx @cedricboeckx.bsky.social · 1d

Very nice study by @hannahlong.bsky.social in @dev-journal.bsky.social testing the impact of a Neanderthal-derived variant on the activity of an enhancer regulating aspects of jaw development 🧪🧬

journals.biologists.com/dev/article/...

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Cedric Boeckx @cedricboeckx.bsky.social · 1d

Congrats!

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Reposted by Cedric Boeckx

Alex Pollen @brainevodevo.bsky.social · 4d

Our new manuscript, led by Emily Corrigan, examines inhibitory neuron diversity across approximately 160 million years of evolutionary divergence, as part of BRAIN Initiative Cell Atlas Network (BICAN) developing brain atlas package: www.nature.com/articles/s41...

Conservation and alteration of mammalian striatal interneurons - Nature

An analysis of cell-type diversity in brain samples from a variety of mammalian species, both during development and in adult animals, reveals that the TAC3 initial class of striatal interneurons is c...

www.nature.com

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Reposted by Cedric Boeckx

moorjanipriya.bsky.social @moorjanipriya.bsky.social · 4d

Our findings show that lactase persistence evolved not through a single story of selection, but as a mosaic shaped by diverse demographic and cultural histories, each leaving a distinct mark on the genome.

We thank our collaborators and welcome any feedback!

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Reposted by Cedric Boeckx

Hank Greely @hankgreely.bsky.social · 5d

Just published! Pasca & Greely (1st, last, & corresponding authors) The Need for a Global Effort To Attend To Human Neural Organoid & Assembloid Research, SCIENCE 390(6773):574-577 (Nov. 6, 2025)
We think it's a big deal!
Other authors on next post-too many to fit.
www.science.org/doi/10.1126/...

The need for a global effort to attend to human neural organoid and assembloid research

A continuing international process is needed to monitor and advise this rapidly progressing field

www.science.org

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Cedric Boeckx @cedricboeckx.bsky.social · 5d

Huge thanks to @drelenamiu.bsky.social @felixthehauskat.bsky.social @sheinalew.bsky.social @ndersen.bsky.social for organizing an excellent & true _work_-shop @aiasdk.bsky.social. I go back with a long reading list, tons of notes & food for thought re: extended childhood, innovation & evolution 🙏

Cedric Boeckx @cedricboeckx.bsky.social · 7d

First time in Aarhus. Grateful to @felixthehauskat.bsky.social @drelenamiu.bsky.social for inviting me to a great workshop on ontogeny, phylogeny, innovation & adaptation, seeking to understand what makes human childhood special @aiasdk.bsky.social @au.dk

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Cedric Boeckx @cedricboeckx.bsky.social · 5d

Outstanding work by @jeffspence.github.io @hakha.bsky.social
@jkpritch.bsky.social & colleagues
“Specificity, length and luck drive gene rankings in association studies”, out in @nature.com
🧪🧬
👇

Jeff Spence @jeffspence.github.io · 5d

How do GWAS and rare variant burden tests rank gene signals?

In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!

🧬🧪🧵

www.nature.com/articles/s41...

Specificity, length and luck drive gene rankings in association studies - Nature

Genetic association tests prioritize candidate genes based on different criteria.

www.nature.com

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Cedric Boeckx @cedricboeckx.bsky.social · 5d

Terrific work! Glad to see this out in print 👏👏

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Reposted by Cedric Boeckx

Jeff Spence @jeffspence.github.io · 5d

How do GWAS and rare variant burden tests rank gene signals?

In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!

🧬🧪🧵

www.nature.com/articles/s41...

Specificity, length and luck drive gene rankings in association studies - Nature

Genetic association tests prioritize candidate genes based on different criteria.

www.nature.com

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Reposted by Cedric Boeckx

Kevin Mitchell @wiringthebrain.bsky.social · 5d

Lineage-resolved atlas of the developing human cortex www.nature.com/articles/s41...

Lineage-resolved atlas of the developing human cortex - Nature

Lineage tracing in human tissue samples from gestational weeks 16 to 24 provides insight into lineage relationships between cortical cell types and shows a switch in progenitor output from glutamaterg...

www.nature.com

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Reposted by Cedric Boeckx

Johanna Joyce @johannajoyce.bsky.social · 6d

New issue of Nature - with NINE studies on #brain #development from the BRAIN Initiative Cell Atlas Network (BICAN) 🧠🧪🔬

An amazing set of resources for all scientists working on the brain!

🧠 Immersive feature:
www.nature.com/immersive/d4...

🧠 Perspective:
www.nature.com/articles/s41...

Cover of this week's Nature showing a brain rendering

Cover caption from the journal:
Brain development:
Our ability to process information into complex emotions, behaviours and decisions relies on the rich diversity of cell types that make up the human brain. Uncovering the molecular and cellular events that take place during brain development could reveal not only the mechanisms that give rise to this diversity but also shed light on how this process might go awry in neurodevelopmental disorders such as autism and schizophrenia. In this week’s issue, the BRAIN Initiative Cell Atlas Network (BICAN) builds on its previous work creating atlases of cell types in the adult mouse, non-human primate (NHP) and human brains to present cell-type atlases of the developing human, mouse and NHP brains. Across a suite of papers, nine of which are published in Nature, the researchers uncover the complex programs through which cell types emerge during brain development in humans and animals, revealing both the shared and unique features of the human brain. The latest work, along with future research directions, is summed up in a Perspective article by Tomasz Nowakowski and colleagues

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Alexandria Ocasio-Cortez @aoc.bsky.social · 7d

😎😎😎😎 GOOD THINGS CAN STILL HAPPEN 😎😎😎😎

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Cedric Boeckx @cedricboeckx.bsky.social · 7d

First time in Aarhus. Grateful to @felixthehauskat.bsky.social @drelenamiu.bsky.social for inviting me to a great workshop on ontogeny, phylogeny, innovation & adaptation, seeking to understand what makes human childhood special @aiasdk.bsky.social @au.dk

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Cedric Boeckx @cedricboeckx.bsky.social · 8d

New work by @gleesonlab.bsky.social & colleagues in @cp-cellstemcell.bsky.social
“A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders” 🧪🧠🧫🧬

www.cell.com/cell-stem-ce...

A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders

Wang and colleagues present a phenotypic brain organoid atlas for neurodevelopmental disorders, revealing disease-specific cellular and molecular alterations that illuminate NDD pathogenesis. Integrat...

www.cell.com

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Cedric Boeckx @cedricboeckx.bsky.social · 11d

So neat!

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Cedric Boeckx @cedricboeckx.bsky.social · 11d

👏👏

Cedric Boeckx @cedricboeckx.bsky.social · 11d

Very nice work 👏

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