Chuanxin Chen
@cc0447.bsky.social
Associate investigator in GZlab. Fancy how stem cells can generate embryo models.
Reposted by Chuanxin Chen
Online Now! Signaling reprogramming via Stat3 activation unravels high-fidelity human post-implantation embryo modeling #stemcells
Signaling reprogramming via Stat3 activation unravels high-fidelity human post-implantation embryo modeling
Enhanced STAT3 activation combined with TGF-β inhibition reprograms human PSCs into cells specifying all early embryonic lineages. Upon 3D suspension culture, these cells self-organize within 6 days into post-implantation structures mimicking Carnegie stages 5–7 embryos, including gastrulation, with high morphological and molecular fidelity.
dlvr.it
September 16, 2025 at 7:09 PM
Online Now! Signaling reprogramming via Stat3 activation unravels high-fidelity human post-implantation embryo modeling #stemcells
Reposted by Chuanxin Chen
(1/8) Very Happy to share our lab’s 3D post-implantation human embryo model, made via signalling reprograming!
🙌 Huge thanks to the entire team and our collaborators, special shout-out to @cc0447.bsky.social (led the work) and @jinjin-0101.bsky.social (comp. analysis).
www.cell.com/cell-stem-ce...
🙌 Huge thanks to the entire team and our collaborators, special shout-out to @cc0447.bsky.social (led the work) and @jinjin-0101.bsky.social (comp. analysis).
www.cell.com/cell-stem-ce...
Signaling reprogramming via Stat3 activation unravels high-fidelity human post-implantation embryo modeling
Enhanced STAT3 activation combined with TGF-β inhibition reprograms human PSCs into
cells specifying all early embryonic lineages. Upon 3D suspension culture, these cells
self-organize within 6 days i...
www.cell.com
September 16, 2025 at 4:12 PM
(1/8) Very Happy to share our lab’s 3D post-implantation human embryo model, made via signalling reprograming!
🙌 Huge thanks to the entire team and our collaborators, special shout-out to @cc0447.bsky.social (led the work) and @jinjin-0101.bsky.social (comp. analysis).
www.cell.com/cell-stem-ce...
🙌 Huge thanks to the entire team and our collaborators, special shout-out to @cc0447.bsky.social (led the work) and @jinjin-0101.bsky.social (comp. analysis).
www.cell.com/cell-stem-ce...
Reposted by Chuanxin Chen
Very happy to share the work of Huanhuan Li et al. While not a natural embryo, you might not have known that if I hadn’t told you. (1/3)
August 7, 2025 at 3:58 PM
Very happy to share the work of Huanhuan Li et al. While not a natural embryo, you might not have known that if I hadn’t told you. (1/3)
Reposted by Chuanxin Chen
Now online! A complete model of mouse embryogenesis through organogenesis enabled by chemically induced embryo founder cells
A complete model of mouse embryogenesis through organogenesis enabled by chemically induced embryo founder cells
A small-molecule-only strategy enables reprogramming ESCs into embryo founder cells that give rise to a high-fidelity embryo model directly and efficiently. This embryo model replicates embryogenesis from initial cell fate specification through E8.5–E8.75-like organogenesis, capturing all key developmental features within a single system.
dlvr.it
August 8, 2025 at 12:42 PM
Now online! A complete model of mouse embryogenesis through organogenesis enabled by chemically induced embryo founder cells