Caitlin Mallory
@caitlinmallory.bsky.social
HHMI Hanna Gray Fellow, current postdoc at UC Berkeley. Interested in memory, imagination, replay and internally-generated sequences. Other main interests include children (especially my 3 y/o daughter) and dachshunds (borderline obsession).
Come hang out with me tomorrow afternoon at poster JJ5! I'll be sharing new work investigating how replay features like rate of occurrence, speed and self-avoidance change dynamically with learning at behaviorally relevant locations
November 15, 2025 at 3:11 AM
Come hang out with me tomorrow afternoon at poster JJ5! I'll be sharing new work investigating how replay features like rate of occurrence, speed and self-avoidance change dynamically with learning at behaviorally relevant locations
14/19 Finally, we considered whether a recurrent network endowed with neuronal fatigue could recapitulate this counterintuitive organization of replay. We found that, in our model, adaptation not only *generates* replay, but it also organizes it.
January 31, 2025 at 9:14 PM
14/19 Finally, we considered whether a recurrent network endowed with neuronal fatigue could recapitulate this counterintuitive organization of replay. We found that, in our model, adaptation not only *generates* replay, but it also organizes it.
13/19 We optogenetically (or chemogenetically) shut down MEC as rats consumed reward. We indeed found that retrospective replays became less frequent with MEC suppressed, although they were not altogether abolished.
January 31, 2025 at 9:14 PM
13/19 We optogenetically (or chemogenetically) shut down MEC as rats consumed reward. We indeed found that retrospective replays became less frequent with MEC suppressed, although they were not altogether abolished.
11/19 This made us wonder, would *replay* of a path also fatigue the participating cells and prevent a subsequent replay of the same path? Consistent with the idea, we found that when two replays occur back-to-back (within about 1 sec), the second replay avoids the first.
January 31, 2025 at 9:14 PM
11/19 This made us wonder, would *replay* of a path also fatigue the participating cells and prevent a subsequent replay of the same path? Consistent with the idea, we found that when two replays occur back-to-back (within about 1 sec), the second replay avoids the first.
9/19 So, which did we observe? Clearly, the latter- when the past and future paths overlapped, replay avoided them both for the first few seconds.
January 31, 2025 at 9:14 PM
9/19 So, which did we observe? Clearly, the latter- when the past and future paths overlapped, replay avoided them both for the first few seconds.
5/19 Here’s another way of visualizing the open field data, considering ALL replays. Every replay contributes 2 points to the bottom left plot: an angle relative to the rat’s future path (green) and an angle relative to the rat’s past path (purple). This tells a similar story.
January 31, 2025 at 9:14 PM
5/19 Here’s another way of visualizing the open field data, considering ALL replays. Every replay contributes 2 points to the bottom left plot: an angle relative to the rat’s future path (green) and an angle relative to the rat’s past path (purple). This tells a similar story.
4/19 Do replays in the open arena also change over the stopping period? We classified replays strongly aligned with the rat’s future path as ‘prospective’ and those strongly aligned with his past as ‘retrospective’. Strikingly, prospective replays preceded retrospective replays.
January 31, 2025 at 9:14 PM
4/19 Do replays in the open arena also change over the stopping period? We classified replays strongly aligned with the rat’s future path as ‘prospective’ and those strongly aligned with his past as ‘retrospective’. Strikingly, prospective replays preceded retrospective replays.
3/19 We noticed a surprising and highly consistent organization of hippocampal replay. On the linear track, forward replays of the rat’s upcoming path preceded reverse replays of his past path.
January 31, 2025 at 9:14 PM
3/19 We noticed a surprising and highly consistent organization of hippocampal replay. On the linear track, forward replays of the rat’s upcoming path preceded reverse replays of his past path.