Michael
@ca480vbb.bsky.social
PhD in particle physics & former fellow at Erlangen Univ. / Max Planck Institute, battling a LC like illness since '19. 七転八起。#LongX #NDPH #POTS #Fibro #SFN #ME #PostVac. #BuyEU 🇪🇺🇺🇦
Thank you!
To summarize:
t = 1hr daily
f = 20Hz
pulse width = 200µs
current I = 1mA below discomfort
Do I understand correctly, they set I not to 1mA but 1mA lower than an I that is uncomfortable? Also they relate I to the average of half the bradycardia threshold. Did you understand that?
To summarize:
t = 1hr daily
f = 20Hz
pulse width = 200µs
current I = 1mA below discomfort
Do I understand correctly, they set I not to 1mA but 1mA lower than an I that is uncomfortable? Also they relate I to the average of half the bradycardia threshold. Did you understand that?
March 19, 2025 at 4:30 PM
Thank you!
To summarize:
t = 1hr daily
f = 20Hz
pulse width = 200µs
current I = 1mA below discomfort
Do I understand correctly, they set I not to 1mA but 1mA lower than an I that is uncomfortable? Also they relate I to the average of half the bradycardia threshold. Did you understand that?
To summarize:
t = 1hr daily
f = 20Hz
pulse width = 200µs
current I = 1mA below discomfort
Do I understand correctly, they set I not to 1mA but 1mA lower than an I that is uncomfortable? Also they relate I to the average of half the bradycardia threshold. Did you understand that?
Thank you, that was really helpful!
March 18, 2025 at 5:49 PM
Thank you, that was really helpful!
Thanks! So you can replicate the settings of the study? Also regarding the ear piece?
The 3.5k€ one advertises that it can also stimulate the cymba concha (for full vagus stimulation), opposed to usual devices.
Though the study seems to affect Tragus only anyways.
t-vns.com
The 3.5k€ one advertises that it can also stimulate the cymba concha (for full vagus stimulation), opposed to usual devices.
Though the study seems to affect Tragus only anyways.
t-vns.com
tVNS Technologies GmbH – Smart | Neuro | Therapies
t-vns.com
March 18, 2025 at 8:48 AM
Thanks! So you can replicate the settings of the study? Also regarding the ear piece?
The 3.5k€ one advertises that it can also stimulate the cymba concha (for full vagus stimulation), opposed to usual devices.
Though the study seems to affect Tragus only anyways.
t-vns.com
The 3.5k€ one advertises that it can also stimulate the cymba concha (for full vagus stimulation), opposed to usual devices.
Though the study seems to affect Tragus only anyways.
t-vns.com
Unfortunately, it seems to be quite expensive. We have a local producer here and the device is 3.5k€...
March 17, 2025 at 6:27 PM
Unfortunately, it seems to be quite expensive. We have a local producer here and the device is 3.5k€...
Could be, like primary (slightly) significant but secondaries not or so. But hope not.
Otherwise, if the result is "good" (just not good enough to justify spending ~~50 Mio. $) this would be very significant imo. Fibro definition is v broad and the med only reduces down to ~~20% IgG.
Otherwise, if the result is "good" (just not good enough to justify spending ~~50 Mio. $) this would be very significant imo. Fibro definition is v broad and the med only reduces down to ~~20% IgG.
March 2, 2025 at 5:01 PM
Could be, like primary (slightly) significant but secondaries not or so. But hope not.
Otherwise, if the result is "good" (just not good enough to justify spending ~~50 Mio. $) this would be very significant imo. Fibro definition is v broad and the med only reduces down to ~~20% IgG.
Otherwise, if the result is "good" (just not good enough to justify spending ~~50 Mio. $) this would be very significant imo. Fibro definition is v broad and the med only reduces down to ~~20% IgG.
Detailed results coming in April:
bsky.app/profile/ca48...
bsky.app/profile/ca48...
It seems that the results of the IgG-reducer #Fibromyalgia study (clinicaltrials.gov/study/NCT056...) will be released no later than April 25th.
Results are scheduled to be reported on a conference:
efic2025.abstractserver.com/program/#/de...
Results are scheduled to be reported on a conference:
efic2025.abstractserver.com/program/#/de...
February 27, 2025 at 9:06 PM
Detailed results coming in April:
bsky.app/profile/ca48...
bsky.app/profile/ca48...
February 27, 2025 at 8:58 PM
Does "predefined criteria" mean some internal criteria to deem it worthy for Phase 3 (maybe not good enough over placebo), or is it directly related to the trial design? No idea.
February 27, 2025 at 8:55 PM
Does "predefined criteria" mean some internal criteria to deem it worthy for Phase 3 (maybe not good enough over placebo), or is it directly related to the trial design? No idea.
February 27, 2025 at 8:51 PM