Robert Haining
@budluddy.bsky.social
Scientist, artist, naive believer that there is still some kind in humankind. Biochemistry is life. Neuromelanin is functional in human brain, and so are glutamate polymers. We call the latter 'chlorophyll' in plants. DNA is mitochondrial poop. Fight me.
Reposted by Robert Haining
April 4, 2025 at 10:08 PM
These turned out alright! Wood and dyed acrylic epoxy polymer. Goofing around with some ideas. Desperately trying to maintain some measure of sanity.
March 12, 2025 at 5:50 PM
These turned out alright! Wood and dyed acrylic epoxy polymer. Goofing around with some ideas. Desperately trying to maintain some measure of sanity.
Reposted by Robert Haining
"One can imagine their outrage had a Democrat expressed such views." www.liberalcurrents.com/the-suicide-...
The Suicide of American Conservatism
American conservatism is largely an intellectual corpse, killed by people who claim to be conservatives.
www.liberalcurrents.com
March 12, 2025 at 1:28 AM
"One can imagine their outrage had a Democrat expressed such views." www.liberalcurrents.com/the-suicide-...
He that is without sin among you, let him be the first to cast a stone. I mean, who among us doesn't have 30 or 40 felony convictions, amiright??
March 11, 2025 at 6:15 AM
He that is without sin among you, let him be the first to cast a stone. I mean, who among us doesn't have 30 or 40 felony convictions, amiright??
This is not a test. We repeat, this is NOT a test.
March 9, 2025 at 5:52 AM
This is not a test. We repeat, this is NOT a test.
Anyway, that's a small introduction to me and what I've been thinking about for the last 20+ years. I intend to keep my bsky account positive and leave my political protests on Zuck's sinking ship. You'll see my art and any science I find interesting and notable. (5/5)
March 8, 2025 at 5:37 PM
Anyway, that's a small introduction to me and what I've been thinking about for the last 20+ years. I intend to keep my bsky account positive and leave my political protests on Zuck's sinking ship. You'll see my art and any science I find interesting and notable. (5/5)
Again, the big deal here is that the molecules that 'go bad' in these diseases ARE NOT gene products. We'll never find 'a' gene for them, only ~7% of PD cases have a known genetic basis, all related to melanin disposition, mitochondrial dysfunction, or inflammation. pubmed.ncbi.nlm.nih.gov/28469642/
Neuromelanin, one of the most overlooked molecules in modern medicine, is not a spectator - PubMed
The loss of pigmented neurons from the human brain has long been the hallmark of Parkinson's disease (PD). Neuromelanin (NM) in the pre-synaptic terminal of dopamine neurons is emerging as a primary p...
pubmed.ncbi.nlm.nih.gov
March 8, 2025 at 5:34 PM
Again, the big deal here is that the molecules that 'go bad' in these diseases ARE NOT gene products. We'll never find 'a' gene for them, only ~7% of PD cases have a known genetic basis, all related to melanin disposition, mitochondrial dysfunction, or inflammation. pubmed.ncbi.nlm.nih.gov/28469642/
These polymers are foreign to the immune system and releasing them triggers inflammation. In PD, melanized dopaminergic neurons leak polymer leading to an autoimmune cascade and eventual diseased state. I'm including a link to my hypothesis paper (>100 citations) on PD. Alzheimer's is similar (3?/?)
March 8, 2025 at 5:31 PM
These polymers are foreign to the immune system and releasing them triggers inflammation. In PD, melanized dopaminergic neurons leak polymer leading to an autoimmune cascade and eventual diseased state. I'm including a link to my hypothesis paper (>100 citations) on PD. Alzheimer's is similar (3?/?)
Glutamate and dopamine are distinctly different molecules. Yet behave in similar ways. In particular, when you have enough molecules ('monomers'), they react to form polymers--melanin from dopamine, and what we call 'chlorophylls' from glutamate. Both form heme-like, metal binding domains. (2/?)
March 8, 2025 at 5:24 PM
Glutamate and dopamine are distinctly different molecules. Yet behave in similar ways. In particular, when you have enough molecules ('monomers'), they react to form polymers--melanin from dopamine, and what we call 'chlorophylls' from glutamate. Both form heme-like, metal binding domains. (2/?)
Why Alzheimer's and Parkinson's mysteries have been so difficult to solve boils down to one simple fact: the deficiency is a pure chemistry one. That is, the molecular process underlying both diseases is a functional macromolecule that is NOT the product of a gene or genes. (1/?)
March 8, 2025 at 5:20 PM
Why Alzheimer's and Parkinson's mysteries have been so difficult to solve boils down to one simple fact: the deficiency is a pure chemistry one. That is, the molecular process underlying both diseases is a functional macromolecule that is NOT the product of a gene or genes. (1/?)
I daresay we won't be seeing 'The Art of Diplomacy' in print anytime soon.
March 1, 2025 at 12:56 AM
I daresay we won't be seeing 'The Art of Diplomacy' in print anytime soon.
Prototype in progress. Seems I need to find my anti-static stuff--that acrylic really attracts the dust, eh??!
February 9, 2025 at 11:52 PM
Prototype in progress. Seems I need to find my anti-static stuff--that acrylic really attracts the dust, eh??!
Desperately trying to stay sane by keeping busy. There was a hiccup with one of our guest artists for this coming year--a woodworker who I was excited about, turns out was unable to attend the reception. A solution was put forth: Have a 'Three Woodsmen' show, me being one of them. Show idea piece.
February 1, 2025 at 7:58 AM
Desperately trying to stay sane by keeping busy. There was a hiccup with one of our guest artists for this coming year--a woodworker who I was excited about, turns out was unable to attend the reception. A solution was put forth: Have a 'Three Woodsmen' show, me being one of them. Show idea piece.
New, perhaps temporary until I get more creative, business cards out at the gallery. Merry Christmas!
December 11, 2024 at 9:45 PM
New, perhaps temporary until I get more creative, business cards out at the gallery. Merry Christmas!
Robert Haining, alive and well.
December 5, 2024 at 2:43 AM
Robert Haining, alive and well.