@bskytdp.bsky.social
1984.....on steroids?!
November 29, 2025 at 12:43 AM
1984.....on steroids?!
Now, imagine them at the level of proteoforms...Mind-bending!
November 26, 2025 at 8:02 PM
Now, imagine them at the level of proteoforms...Mind-bending!
Funny how that is considering proteomes are composed of proteoforms! This is a great addition to promoting Integrative-TDP analyses which actually assess intact proteoforms which 'I see all the time, they are everywhere'...& what need to analyzed to ID the best possible biomarkers and drug targets.
November 26, 2025 at 3:43 PM
Funny how that is considering proteomes are composed of proteoforms! This is a great addition to promoting Integrative-TDP analyses which actually assess intact proteoforms which 'I see all the time, they are everywhere'...& what need to analyzed to ID the best possible biomarkers and drug targets.
The other provinces need to take a serious look at this review....and also a hard look at the hard questions finally being asked of the system in Australia as well.
Things can't go on as they are and the answer is not simply 'give them more money' as that will only further the broken status quo.
Things can't go on as they are and the answer is not simply 'give them more money' as that will only further the broken status quo.
November 26, 2025 at 1:41 AM
The other provinces need to take a serious look at this review....and also a hard look at the hard questions finally being asked of the system in Australia as well.
Things can't go on as they are and the answer is not simply 'give them more money' as that will only further the broken status quo.
Things can't go on as they are and the answer is not simply 'give them more money' as that will only further the broken status quo.
Many of these are no longer productive yet also complain that 'we need to give younger academics a chance'. Then, by all means, make room if you are no longer being productive.
November 25, 2025 at 9:15 PM
Many of these are no longer productive yet also complain that 'we need to give younger academics a chance'. Then, by all means, make room if you are no longer being productive.
Needs to happen at many Canadian universities, but include complete turnover of Boards as well a wide swath of incompetent senior administrators.
We should be doing so much better with the trust and funding of the public.
We should be doing so much better with the trust and funding of the public.
November 25, 2025 at 9:10 PM
Needs to happen at many Canadian universities, but include complete turnover of Boards as well a wide swath of incompetent senior administrators.
We should be doing so much better with the trust and funding of the public.
We should be doing so much better with the trust and funding of the public.
Yes, that 'combined' effort is called integrative top-down proteomics - you can easily read about the concept from even earlier papers.
Glad to see Proteomics get on board. I was also pleased to see that the need to analyze proteomes at the proteoform level was well noted at the HUPO meeting too.
Glad to see Proteomics get on board. I was also pleased to see that the need to analyze proteomes at the proteoform level was well noted at the HUPO meeting too.
November 14, 2025 at 1:35 AM
Yes, that 'combined' effort is called integrative top-down proteomics - you can easily read about the concept from even earlier papers.
Glad to see Proteomics get on board. I was also pleased to see that the need to analyze proteomes at the proteoform level was well noted at the HUPO meeting too.
Glad to see Proteomics get on board. I was also pleased to see that the need to analyze proteomes at the proteoform level was well noted at the HUPO meeting too.
You offered to shovel in return for a price reduction on the room?
November 10, 2025 at 12:13 AM
You offered to shovel in return for a price reduction on the room?
The 'alternative' methods still do not enable truly comprehensive proteome analysis at the proteoform level. Some 'alternatives' detect a few specific proteoforms with Ab's (quality?), but are broadly just other ways to do bottom-up.
When do we get quality over quantity, & make it the priority?
When do we get quality over quantity, & make it the priority?
November 8, 2025 at 8:27 PM
The 'alternative' methods still do not enable truly comprehensive proteome analysis at the proteoform level. Some 'alternatives' detect a few specific proteoforms with Ab's (quality?), but are broadly just other ways to do bottom-up.
When do we get quality over quantity, & make it the priority?
When do we get quality over quantity, & make it the priority?
Lift with your legs!
November 8, 2025 at 2:56 PM
Lift with your legs!
...and not so great papers as well...
November 8, 2025 at 1:57 PM
...and not so great papers as well...
Are you sure it isn't a mass spec conference?
November 8, 2025 at 1:54 PM
Are you sure it isn't a mass spec conference?
Although it will be unseasonably cold (just for the few days of the HUPO meeting!), I doubt any snow accumulation on Sunday. Will feel quite cold due to high humidity. Anybody leaving the hotel/conference should bring warm clothes. That is, I am assuming you flights come through from the US!
November 7, 2025 at 6:46 PM
Although it will be unseasonably cold (just for the few days of the HUPO meeting!), I doubt any snow accumulation on Sunday. Will feel quite cold due to high humidity. Anybody leaving the hotel/conference should bring warm clothes. That is, I am assuming you flights come through from the US!
Indeed, a truly outdated (already when established) group that subsists on mutual appreciation (e.g. Oh, their work must be good because they are doing exactly the same thing I am, exactly the same way).
Just a way to funnel money to a few select groups at a few select institutions.
Just a way to funnel money to a few select groups at a few select institutions.
November 6, 2025 at 1:58 PM
Indeed, a truly outdated (already when established) group that subsists on mutual appreciation (e.g. Oh, their work must be good because they are doing exactly the same thing I am, exactly the same way).
Just a way to funnel money to a few select groups at a few select institutions.
Just a way to funnel money to a few select groups at a few select institutions.
Gotta keep those mice healthy!
The issue is beyond claiming to have identified a POTENTIAL biomarker (my emphasis) but on the supposed 'validation' of findings. Manuscripts I have reviewed over several years fail miserably in this regard, seemingly in order to verify rather than test a hypothesis.
The issue is beyond claiming to have identified a POTENTIAL biomarker (my emphasis) but on the supposed 'validation' of findings. Manuscripts I have reviewed over several years fail miserably in this regard, seemingly in order to verify rather than test a hypothesis.
November 5, 2025 at 3:07 PM
Gotta keep those mice healthy!
The issue is beyond claiming to have identified a POTENTIAL biomarker (my emphasis) but on the supposed 'validation' of findings. Manuscripts I have reviewed over several years fail miserably in this regard, seemingly in order to verify rather than test a hypothesis.
The issue is beyond claiming to have identified a POTENTIAL biomarker (my emphasis) but on the supposed 'validation' of findings. Manuscripts I have reviewed over several years fail miserably in this regard, seemingly in order to verify rather than test a hypothesis.
Hopefully those committee meetings were recorded or at least detailed minutes taken so those can be released to the public...nothing nefarious at work then transparency should not be an issue. Right??
Reminds me too much of how university senior administrators operate & too many uni boards as well.
Reminds me too much of how university senior administrators operate & too many uni boards as well.
November 5, 2025 at 2:23 AM
Hopefully those committee meetings were recorded or at least detailed minutes taken so those can be released to the public...nothing nefarious at work then transparency should not be an issue. Right??
Reminds me too much of how university senior administrators operate & too many uni boards as well.
Reminds me too much of how university senior administrators operate & too many uni boards as well.
It could get even goofier and the decisions made even less transparent?!? Didn't think that possible.
November 4, 2025 at 5:16 PM
It could get even goofier and the decisions made even less transparent?!? Didn't think that possible.
If only it were actually proteoforms rather than a few more peptides to infer the identity of a supposedly full length canonical amino acid sequence.
November 3, 2025 at 3:00 PM
If only it were actually proteoforms rather than a few more peptides to infer the identity of a supposedly full length canonical amino acid sequence.
Handed....or have they simply taken it via strategic long-term investment? Having visited several times over the last 20+ years, including last year, science in China is not only international calibre but is now a defining international 'force' in science. Hopefully not stating the obvious.
November 2, 2025 at 6:51 PM
Handed....or have they simply taken it via strategic long-term investment? Having visited several times over the last 20+ years, including last year, science in China is not only international calibre but is now a defining international 'force' in science. Hopefully not stating the obvious.
Platelets are amazing....& more so as so many know so little about them.What has been learned about their contents, functions and breadth of contributions to systems physiology over the last 30+ years is truly fascinating.
October 31, 2025 at 9:59 PM
Platelets are amazing....& more so as so many know so little about them.What has been learned about their contents, functions and breadth of contributions to systems physiology over the last 30+ years is truly fascinating.
Blanchette-Joncas is also Vice-Chair. I recognize 1 name on committee as an MD who probably hasn't practiced in decades, but does anyone have a science bckgrnd? Regardless, most info they are requesting is irrelevant in terms of the quality (or not) of what is funded.
Definition of over-reach.
Definition of over-reach.
October 31, 2025 at 12:02 AM
Blanchette-Joncas is also Vice-Chair. I recognize 1 name on committee as an MD who probably hasn't practiced in decades, but does anyone have a science bckgrnd? Regardless, most info they are requesting is irrelevant in terms of the quality (or not) of what is funded.
Definition of over-reach.
Definition of over-reach.
You can go ahead & substitute 'Canada' or pretty much any other Western nation for 'UK'.
Until the deep seated problems that have gotten us to this point are transparently recognized & those responsible take responsibility, there is little hope of things improving.
We should be doing so much better.
Until the deep seated problems that have gotten us to this point are transparently recognized & those responsible take responsibility, there is little hope of things improving.
We should be doing so much better.
October 29, 2025 at 5:05 PM
You can go ahead & substitute 'Canada' or pretty much any other Western nation for 'UK'.
Until the deep seated problems that have gotten us to this point are transparently recognized & those responsible take responsibility, there is little hope of things improving.
We should be doing so much better.
Until the deep seated problems that have gotten us to this point are transparently recognized & those responsible take responsibility, there is little hope of things improving.
We should be doing so much better.
Gotta have all the sexy buzzwords & 'outlook' to satisfy current grant schemes & reviewers who generally seem taken in by this.
October 28, 2025 at 6:03 PM
Gotta have all the sexy buzzwords & 'outlook' to satisfy current grant schemes & reviewers who generally seem taken in by this.
'We have been measuring proteomes - at the level of canonical sequences - for a long time...'
Indeed, addressing data at the systems level & constructively confronting that complexity has lagged far behind.
I'll say it yet again - we can & should be doing so much better.
Thanks for this Phil!
Indeed, addressing data at the systems level & constructively confronting that complexity has lagged far behind.
I'll say it yet again - we can & should be doing so much better.
Thanks for this Phil!
October 27, 2025 at 11:53 PM
'We have been measuring proteomes - at the level of canonical sequences - for a long time...'
Indeed, addressing data at the systems level & constructively confronting that complexity has lagged far behind.
I'll say it yet again - we can & should be doing so much better.
Thanks for this Phil!
Indeed, addressing data at the systems level & constructively confronting that complexity has lagged far behind.
I'll say it yet again - we can & should be doing so much better.
Thanks for this Phil!
A pathology of mid-to-senior level university administrators trying to justify their existence by seemingly creating new forms every 12 months (or less!). Regrettably, not only in the UK!
October 27, 2025 at 1:40 AM
A pathology of mid-to-senior level university administrators trying to justify their existence by seemingly creating new forms every 12 months (or less!). Regrettably, not only in the UK!