More than 100 minutes… so between 1.5-2 hours of material? doesn’t sound like sufficient data to make any meaningful conclusions 🤷‍♀️

thanks! it was great to meet you too, see you at the next conference!

... but before leaving Vienna, I couldn't resist some local #patisserie 🍰 Just... glorious.

thanks @iuisjuniorcomm.bsky.social for inviting us to their career fair where I had a chance to talk about how I got started with my #sci_comm gig! I loved the discussion afterwards

Cool abstract talks from Charlotte Zajc @meduniwien.ac.at about engineering CARs with ON- and OFF-switches modulated by small molecules & Carolina Mangana @cemm.oeaw.ac.at about changes in tumor-draining LNs brought up by increased myeloid (Mo/Mac) infiltration and loss of T cell zone
#IUIS2025

Gabriel is opening a new lab in #Barcelona with support of @caixaresearch.bsky.social - and they are hiring!

Next in the session: Gabriel Rabinovich (@University of Buenos Aires)☝️ Galectin 1 promotes tumor growth in many ways, such interaction w/ VEGFR2 to promote angiogenesis (resistant to anti-VEGF therapy) & enhancement of myeloid suppressor cells 💡GAL1-neutralizing mAb could help.
#IUIS2025

... 2️⃣ Logic-gating: IF-BETTER gates target 2 antigens-> enhanced activity when primary Ag expression low 3️⃣ inactivating mutation of 2/3 of CD3 ITAM domains improves CAR-T cell persistence w/o affecting function - only 25M dose sufficient for protective response in B cell lymphoma

Also in the #neuroimmunology session: David Hafler @yaleschoolofmed.bsky.social - IFNg+CD4 cells in brain: come from gut, similar to WAT T cells, affect behavior / increased infiltration in early Parkinson's brain precedes symptoms - could targeting this inflammation be key to prevent progression?

just look at those little buddies interacting in vitro! #neuroimmunology

Also on #IUIS2025 Day 3: keynote by Ruslan Medzhitov. Pet shop mice have pre-existing immunity (look at the size of those LNs!) and a crowded "antigenic space" with Th1/17/reg immunity. Allergic sensitization in SPF mice is possible because the antigenic space is available for full blown Th2

Next up: BRAIN EATING AMOEBA 😱 - Ashley Moseman from @duke-university.bsky.social: N. fowleri infection starts through olfactory nerves 👃 and because complement proteins: ❌ can't cross blood-olfactory barrier ❌ can't mark amoeba for neutrophil attack, pathogen 🦠 reaches brain ahead of immune cells 😵

Check out their pre-print! www.biorxiv.org/content/10.1...

Later on: @victora.bsky.social at RockefellerU used brainbow mice to study BCR evolution in individual GCs - tl;dr: GCs mostly do mutations that are easy, not most enhancing/ GCs are intolerant to loss of affinity / clonal bursts are not main drivers: rather slow evolution biased to higher affinity

I loved seeing the story from @iannaconelab.bsky.social presented live! HBV-infected hepatocytes can prime CD8 cells directly but CD4 help -> Kupffer cells (not DCs) -> CD27 is needed to prevent dysfunction (check episode #109 of @immunologypodcast.com for the full story!)

#IUIS2025 Rising Stars: Thomas Krausgruber (@cemm.oeaw.ac.at ) w/ role of structural cells in response to acute/chronic LCMV infecions, Thomas Vogl (@meduniwien.ac.at) dramatic changes in Ab repertoires in 1y of life & @kedmiranit.bsky.social on interacting Rorgt+ APC and pTregs in oral tolerance.