Johannes Brägelmann
@braegelmannlab.bsky.social
Physician & biostatistician. Excited about cancer research, tumor evolution & functional genomics, driven to improve cancer therapy
Reposted by Johannes Brägelmann
Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years?
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
October 9, 2025 at 6:06 PM
Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years?
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
Reposted by Johannes Brägelmann
Signalling between neurons and tumour cells in the lung and brain promotes the growth of small-cell lung cancer
go.nature.com/4gzoMmI
go.nature.com/4gzoMmI
Wired for growth: neuron–tumour signalling in the lung and brain increases growth of a hard-to-treat cancer
Signalling between neurons and tumour cells in the lung and brain promotes the growth of small-cell lung cancer. These interactions might be a therapeutic target.
go.nature.com
September 17, 2025 at 6:32 PM
Signalling between neurons and tumour cells in the lung and brain promotes the growth of small-cell lung cancer
go.nature.com/4gzoMmI
go.nature.com/4gzoMmI
Reposted by Johannes Brägelmann
Super pleased to announce our latest suggesting the cell of origin for #SCLC is most likely the basal cell @nature.com, not the accepted neuroendocrine cell. Implications for the earliest events in cancer, & providing new models of tuft-like cancer.
rdcu.be/eGUtj
rdcu.be/eGUtj
Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer
Nature - Basal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrine–tuft cancers, explaining...
rdcu.be
September 17, 2025 at 3:21 PM
Super pleased to announce our latest suggesting the cell of origin for #SCLC is most likely the basal cell @nature.com, not the accepted neuroendocrine cell. Implications for the earliest events in cancer, & providing new models of tuft-like cancer.
rdcu.be/eGUtj
rdcu.be/eGUtj
Reposted by Johannes Brägelmann
Neurons often receive mitochondria from other cells, supporting cancer cell spread
https://go.nature.com/3ZLBhnV
https://go.nature.com/3ZLBhnV
Neuronal transfer of mitochondria to tumour cells promotes cancer spread
Neurons often receive organelles called mitochondria from other cells. It emerges that neurons donate mitochondria that support cancer-cell spread.
go.nature.com
July 1, 2025 at 7:47 AM
Neurons often receive mitochondria from other cells, supporting cancer cell spread
https://go.nature.com/3ZLBhnV
https://go.nature.com/3ZLBhnV