Dr. Donita C. Brady of Brady Lab UPenn
@bradylabupenn.bsky.social
Presidential Associate Professor of Cancer Biology
@Penn_CBIO & Asst. Dean @RTAatPennMed @PennMedicine. Posts her own.✊🏾🏳️🌈
@Penn_CBIO & Asst. Dean @RTAatPennMed @PennMedicine. Posts her own.✊🏾🏳️🌈
www.cell.com
September 27, 2025 at 3:27 PM
www.cell.com
September 27, 2025 at 3:26 PM
By mutating PERK’s copper-binding sites, researchers made cells & worms hypersensitive to stress. ➡️ Copper availability literally decides survival vs. death.
September 27, 2025 at 2:13 PM
By mutating PERK’s copper-binding sites, researchers made cells & worms hypersensitive to stress. ➡️ Copper availability literally decides survival vs. death.
Cells use metals like copper as molecular switches. Understanding this could open new ways to target stress responses in cancer, neurodegeneration & beyond.
September 27, 2025 at 2:13 PM
Cells use metals like copper as molecular switches. Understanding this could open new ways to target stress responses in cancer, neurodegeneration & beyond.
This is the latest addition to known cases of metallallosteric regulation of a protein kinase. Metal ions aren’t just cofactors — they’re signals that tune cell fate.
September 27, 2025 at 2:13 PM
This is the latest addition to known cases of metallallosteric regulation of a protein kinase. Metal ions aren’t just cofactors — they’re signals that tune cell fate.
Cells are constantly stressed by misfolded proteins. PERK is one of the cell’s “emergency brakes.” This study shows PERK only works if it has copper bound — no copper, no brake.
September 27, 2025 at 2:13 PM
Cells are constantly stressed by misfolded proteins. PERK is one of the cell’s “emergency brakes.” This study shows PERK only works if it has copper bound — no copper, no brake.
This award is not just mine. It reflects the efforts of so many who believe in equal opportunity and mentorship, & opportunity — & who have trusted, supported, & invested in my leadership along the way. @pennmedcso.bsky.social @penncbio.bsky.social @penncancer.bsky.social @rtaatpennmed.bsky.social
September 24, 2025 at 1:10 AM
This award is not just mine. It reflects the efforts of so many who believe in equal opportunity and mentorship, & opportunity — & who have trusted, supported, & invested in my leadership along the way. @pennmedcso.bsky.social @penncbio.bsky.social @penncancer.bsky.social @rtaatpennmed.bsky.social
Reposted by Dr. Donita C. Brady of Brady Lab UPenn
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April 29, 2025 at 3:47 PM
Please help spread the word: @ishahjain.bsky.social @bradylabupenn.bsky.social @naama-kanarek.bsky.social @liron1bar-peled.bsky.social @lydiafinley.bsky.social