Bourbon Henri-Marc
@bourbon-henri.bsky.social
Geneticist retired from CNRS. Drosophila, Developmental genetics, Gene regulation, Molecular evolution, Phylogenomics, Meiosis.
Reposted by Bourbon Henri-Marc
#cryoEM MED23 in complex with the TAD of Elk-1 🧶🧬
www.nature.com/articles/s41...
MED23 density in light gray
MED23 Elk-1 binding site (H19, H21, H28 & H30 helices) in dark gray
Elk-1 TAD (11 aa out of 118) in blue
MED23 HR4-lid which becomes dynamic/disordered upon Elk-1 binding in orange
www.nature.com/articles/s41...
MED23 density in light gray
MED23 Elk-1 binding site (H19, H21, H28 & H30 helices) in dark gray
Elk-1 TAD (11 aa out of 118) in blue
MED23 HR4-lid which becomes dynamic/disordered upon Elk-1 binding in orange
April 23, 2025 at 8:20 AM
#cryoEM MED23 in complex with the TAD of Elk-1 🧶🧬
www.nature.com/articles/s41...
MED23 density in light gray
MED23 Elk-1 binding site (H19, H21, H28 & H30 helices) in dark gray
Elk-1 TAD (11 aa out of 118) in blue
MED23 HR4-lid which becomes dynamic/disordered upon Elk-1 binding in orange
www.nature.com/articles/s41...
MED23 density in light gray
MED23 Elk-1 binding site (H19, H21, H28 & H30 helices) in dark gray
Elk-1 TAD (11 aa out of 118) in blue
MED23 HR4-lid which becomes dynamic/disordered upon Elk-1 binding in orange
Reposted by Bourbon Henri-Marc
🎯Breaking News
Enzyme used in meiosis makes the cut in vitro
News
www.nature.com/articles/d41...
Paper 1
doi.org/10.1038/s415...
Paper 2
doi.org/10.1038/s415...
Paper 3
doi.org/10.1038/s415...
Enzyme used in meiosis makes the cut in vitro
News
www.nature.com/articles/d41...
Paper 1
doi.org/10.1038/s415...
Paper 2
doi.org/10.1038/s415...
Paper 3
doi.org/10.1038/s415...
February 20, 2025 at 6:21 AM
🎯Breaking News
Enzyme used in meiosis makes the cut in vitro
News
www.nature.com/articles/d41...
Paper 1
doi.org/10.1038/s415...
Paper 2
doi.org/10.1038/s415...
Paper 3
doi.org/10.1038/s415...
Enzyme used in meiosis makes the cut in vitro
News
www.nature.com/articles/d41...
Paper 1
doi.org/10.1038/s415...
Paper 2
doi.org/10.1038/s415...
Paper 3
doi.org/10.1038/s415...
Reposted by Bourbon Henri-Marc
Je viens de faire mon #eXit! L’exode de X est massif. Ne perdez pas un seul de vos abonnés. Grâce à #HelloQuitX j’ai inscrit 1570 nouveaux passagers pour partir vers #BlueSky & #Mastodon. Retrouvez automatiquement vos communautés le #20Janvier via app.helloquitx.com !
January 23, 2025 at 7:14 PM
Je viens de faire mon #eXit! L’exode de X est massif. Ne perdez pas un seul de vos abonnés. Grâce à #HelloQuitX j’ai inscrit 1570 nouveaux passagers pour partir vers #BlueSky & #Mastodon. Retrouvez automatiquement vos communautés le #20Janvier via app.helloquitx.com !
Chai-1: Decoding the molecular interactions of life https://www.biorxiv.org/content/10.1101/2024.10.10.615955v2
...now has a Nextflow workflow: https://github.com/seqeralabs/nf-chai from @flowuenne.bsky.social, @drhpatel.bsky.social, and Adam Talbott on the all-star scidev team at @seqera.io
...now has a Nextflow workflow: https://github.com/seqeralabs/nf-chai from @flowuenne.bsky.social, @drhpatel.bsky.social, and Adam Talbott on the all-star scidev team at @seqera.io
December 12, 2024 at 11:11 AM
Reposted by Bourbon Henri-Marc
Hello Bluesky, for my first post here I'm happy to share our latest preprint reporting the first biochemical reconstitution of DNA double-strand break formation by SPO11.
SPO11 dimerization controls meiotic DNA double-strand break formation.
www.biorxiv.org/content/10.1...
SPO11 dimerization controls meiotic DNA double-strand break formation.
www.biorxiv.org/content/10.1...
SPO11 dimerization controls meiotic DNA double-strand break formation
SPO11 initiates meiotic recombination through the induction of programmed DNA double-strand breaks (DSBs), but this catalytic activity had never been reconstituted in vitro. Here, using Mus musculus S...
www.biorxiv.org
November 21, 2024 at 10:18 AM
Hello Bluesky, for my first post here I'm happy to share our latest preprint reporting the first biochemical reconstitution of DNA double-strand break formation by SPO11.
SPO11 dimerization controls meiotic DNA double-strand break formation.
www.biorxiv.org/content/10.1...
SPO11 dimerization controls meiotic DNA double-strand break formation.
www.biorxiv.org/content/10.1...
Evolution and Diversity of the TopoVI and TopoVI-like Subunits With Extensive Divergence of the TOPOVIBL subunit
academic.oup.com/mbe/article/39…
academic.oup.com/mbe/article/39…
Evolution and Diversity of the TopoVI and TopoVI-like Subunits With Extensive Divergence of the TOPOVIBL subunit
Abstract. Type II DNA topoisomerases regulate topology by double-stranded DNA cleavage and ligation. The TopoVI family of DNA topoisomerase, first identifi
academic.oup.com
January 31, 2025 at 8:21 AM
Evolution and Diversity of the TopoVI and TopoVI-like Subunits With Extensive Divergence of the TOPOVIBL subunit
academic.oup.com/mbe/article/39…
academic.oup.com/mbe/article/39…
En science, les plus petites équipes sont les plus innovantesvia @lemondefr
lemonde.fr/sciences/artic…
lemonde.fr/sciences/artic…
En science, les plus petites équipes sont les plus innovantes
CHRONIQUE. Une analyse d’un vaste corpus de publications scientifiques et de brevets montre que les petites équipes de recherche sont en moyenne plus créatives que les grandes.
www.lemonde.fr
January 31, 2025 at 8:21 AM
En science, les plus petites équipes sont les plus innovantesvia @lemondefr
lemonde.fr/sciences/artic…
lemonde.fr/sciences/artic…
January 31, 2025 at 8:20 AM
I wish you a happy new year
January 31, 2025 at 8:20 AM
I wish you a happy new year
January 31, 2025 at 8:20 AM
Post-doctoral position to study in vivo transcriptional regulation at CBI Toulouse France
academicpositions.eu/ad/cbi-toulous…
academicpositions.eu/ad/cbi-toulous…
Academic Positions
Career network for academics, researchers and scientists. Find and apply for jobs in research and higher education today!
academicpositions.eu
January 31, 2025 at 8:20 AM
Post-doctoral position to study in vivo transcriptional regulation at CBI Toulouse France
academicpositions.eu/ad/cbi-toulous…
academicpositions.eu/ad/cbi-toulous…
The fellow will specifically tackle the Med19-Med13 interplay, both structurally and functionally
x.com/schneiderleoni…
x.com/schneiderleoni…
January 31, 2025 at 8:20 AM
The fellow will specifically tackle the Med19-Med13 interplay, both structurally and functionally
x.com/schneiderleoni…
x.com/schneiderleoni…
My lab is seaking for a post-doctoral fellow supported by the french ANR, to investigate functional relationships between core Mediator and the CKM module in Drosophila. Please RT
cbi-toulouse.fr/eng/programme-…
cbi-toulouse.fr/eng/programme-…
CBI -
The Centre for Integrative Biology - CBI in Toulouse is launching its fourth call to hire high-level Post-docs.
cbi-toulouse.fr
January 31, 2025 at 8:20 AM
My lab is seaking for a post-doctoral fellow supported by the french ANR, to investigate functional relationships between core Mediator and the CKM module in Drosophila. Please RT
cbi-toulouse.fr/eng/programme-…
cbi-toulouse.fr/eng/programme-…
The Centre for Integrative Biology of Toulouse (CBI-Toulouse, France) recruits
Group leaders in Cell and Developmental Biology. Application deadline: June 14, 2018. More information here:
cbi-toulouse.fr/fr/actu-new-gr…
Group leaders in Cell and Developmental Biology. Application deadline: June 14, 2018. More information here:
cbi-toulouse.fr/fr/actu-new-gr…
January 31, 2025 at 8:20 AM
The Centre for Integrative Biology of Toulouse (CBI-Toulouse, France) recruits
Group leaders in Cell and Developmental Biology. Application deadline: June 14, 2018. More information here:
cbi-toulouse.fr/fr/actu-new-gr…
Group leaders in Cell and Developmental Biology. Application deadline: June 14, 2018. More information here:
cbi-toulouse.fr/fr/actu-new-gr…
I wish you all a happy new year with the best for 2018.
January 31, 2025 at 8:20 AM
I wish you all a happy new year with the best for 2018.
January 31, 2025 at 8:19 AM
Our last paper accepted in @GenesDev! Asy2/Mer2: a conserved mediator of meiotic recombination, pairing and global chromosome compaction
January 31, 2025 at 8:19 AM
Our last paper accepted in @GenesDev! Asy2/Mer2: a conserved mediator of meiotic recombination, pairing and global chromosome compaction
January 31, 2025 at 8:19 AM
Phylogenomics analyses are
crucial to identify distantly-related protein homologs
science.sciencemag.org/content/351/62…
crucial to identify distantly-related protein homologs
science.sciencemag.org/content/351/62…
The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation
The recombination step in meiosis requires a topoisomerase-like complex of protein subunits.
science.sciencemag.org
January 31, 2025 at 8:19 AM
Phylogenomics analyses are
crucial to identify distantly-related protein homologs
science.sciencemag.org/content/351/62…
crucial to identify distantly-related protein homologs
science.sciencemag.org/content/351/62…
The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation
science.sciencemag.org/content/351/62…
science.sciencemag.org/content/351/62…
The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation
The recombination step in meiosis requires a topoisomerase-like complex of protein subunits.
science.sciencemag.org
January 31, 2025 at 8:19 AM
The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation
science.sciencemag.org/content/351/62…
science.sciencemag.org/content/351/62…
Je suis Charlie. La liberté d'expression est le ciment de notre république.
January 31, 2025 at 8:19 AM
Je suis Charlie. La liberté d'expression est le ciment de notre république.
Happy new year to everybody.
January 31, 2025 at 8:19 AM
Happy new year to everybody.