@blancahimes.bsky.social
Reposted
A simple design framework that will massively improve your slides and your public speaking
clauswilke.substack.com/p/slides-tha...
clauswilke.substack.com/p/slides-tha...
Slide designs that present themselves: The assertion–evidence template
Your slides are not your talk.
clauswilke.substack.com
August 15, 2025 at 11:10 AM
A simple design framework that will massively improve your slides and your public speaking
clauswilke.substack.com/p/slides-tha...
clauswilke.substack.com/p/slides-tha...
Reposted
Super excited to share our new phenome-wide comparison of polygenic and proteomic risk scores in 40,000 people. We find proteins generally outpredict genetics for disease incidence, but polygenic prediction remains important in heritable diseases. medrxiv.org/content/10.1101/2025.07.10.25331242v1
July 15, 2025 at 1:32 AM
Super excited to share our new phenome-wide comparison of polygenic and proteomic risk scores in 40,000 people. We find proteins generally outpredict genetics for disease incidence, but polygenic prediction remains important in heritable diseases. medrxiv.org/content/10.1101/2025.07.10.25331242v1
Reposted
Happy to announce our paper comparing embryonic gene expression between C. elegans and C. briggsae, work led by Christopher Large with Rupa Khanal and in collaboration with Junhyong Kim and Bob Waterston. www.science.org/doi/10.1126/...
Lineage-resolved analysis of embryonic gene expression evolution in C. elegans and C. briggsae
The constraints that govern the evolution of gene expression patterns across development remain unclear. Single-cell RNA sequencing can detail these constraints by systematically profiling homologous ...
www.science.org
June 20, 2025 at 8:25 PM
Happy to announce our paper comparing embryonic gene expression between C. elegans and C. briggsae, work led by Christopher Large with Rupa Khanal and in collaboration with Junhyong Kim and Bob Waterston. www.science.org/doi/10.1126/...
Reposted
After 21 years at my dream job, I’m very sad to announce my early retirement from the National Institutes of Health. My life’s work has been to scientifically study how our food environment affects what we eat, and how what we eat affects our physiology.
April 16, 2025 at 9:00 PM
After 21 years at my dream job, I’m very sad to announce my early retirement from the National Institutes of Health. My life’s work has been to scientifically study how our food environment affects what we eat, and how what we eat affects our physiology.
Reposted
Calling all health professionals who document pt care in the EHR! lnkd.in/ek6V2thU Please take the trend burden survey so we can track and reduce excessive doc burden for clinicians. Only takes 2 minutes. #AMIA25x5 #trendburden
April 9, 2025 at 2:12 PM
Calling all health professionals who document pt care in the EHR! lnkd.in/ek6V2thU Please take the trend burden survey so we can track and reduce excessive doc burden for clinicians. Only takes 2 minutes. #AMIA25x5 #trendburden
Reposted
New preprint! We worked with @msftresearch.bsky.social and @broadinstitute.org to see whether large language models (LLMs) can be useful to variant scientists in deciding whether genetic variants seen in a patient are responsible for their disease. tl;dr yes they can: www.biorxiv.org/content/10.1...
Evidence Aggregator: AI reasoning applied to rare disease diagnostics
Retrieving, reviewing, and synthesizing technical information can be time-consuming and challenging, particularly when requiring specialized expertise, as is the case of variant assessment for rare di...
www.biorxiv.org
March 15, 2025 at 2:44 AM
New preprint! We worked with @msftresearch.bsky.social and @broadinstitute.org to see whether large language models (LLMs) can be useful to variant scientists in deciding whether genetic variants seen in a patient are responsible for their disease. tl;dr yes they can: www.biorxiv.org/content/10.1...
Reposted
In cutthroat cultures, people kiss up and kick down. They protect themselves by currying favor with people in power and exploiting those without it.
In supportive cultures, people speak up and shield down. They protect others who lack power by raising problems to those who have it.
In supportive cultures, people speak up and shield down. They protect others who lack power by raising problems to those who have it.
March 4, 2025 at 5:05 PM
In cutthroat cultures, people kiss up and kick down. They protect themselves by currying favor with people in power and exploiting those without it.
In supportive cultures, people speak up and shield down. They protect others who lack power by raising problems to those who have it.
In supportive cultures, people speak up and shield down. They protect others who lack power by raising problems to those who have it.
Reposted
FYI not only is Pubmed Central a good replacement, @dimensions-ai.bsky.social has a free version with almost complete fulltext search (80%+) for 152 million pubs and datasets. It includes all of Pubmed. You can even filter by Pubmed.
March 2, 2025 at 8:40 AM
FYI not only is Pubmed Central a good replacement, @dimensions-ai.bsky.social has a free version with almost complete fulltext search (80%+) for 152 million pubs and datasets. It includes all of Pubmed. You can even filter by Pubmed.
Reposted
I got laid off today, with the rest of 18F.
18F was an elite federal software shop. We made gov't websites work better, more efficiently for the American people. We saved taxpayers from getting screwed over by contractors. And were fired for it.
We made this website to tell our story:
18f.org
18F was an elite federal software shop. We made gov't websites work better, more efficiently for the American people. We saved taxpayers from getting screwed over by contractors. And were fired for it.
We made this website to tell our story:
18f.org
We're not done yet | 18F
18f.org
March 1, 2025 at 10:38 PM
I got laid off today, with the rest of 18F.
18F was an elite federal software shop. We made gov't websites work better, more efficiently for the American people. We saved taxpayers from getting screwed over by contractors. And were fired for it.
We made this website to tell our story:
18f.org
18F was an elite federal software shop. We made gov't websites work better, more efficiently for the American people. We saved taxpayers from getting screwed over by contractors. And were fired for it.
We made this website to tell our story:
18f.org
Reposted
When OMB head Russ Vought talks about deliberate efforts to put federal employees "in trauma" and make them quit their jobs, he's talking about people like Michelle, recently fired by Musk/Trump.
www.sfgate.com/california/a...
www.sfgate.com/california/a...
February 24, 2025 at 12:04 AM
When OMB head Russ Vought talks about deliberate efforts to put federal employees "in trauma" and make them quit their jobs, he's talking about people like Michelle, recently fired by Musk/Trump.
www.sfgate.com/california/a...
www.sfgate.com/california/a...
Reposted
I've been developing a semantic search tool that covers not just bioRxiv and medRxiv, but the entire PubMed database. This means you can search across a massive collection of biomedical research using keywords, questions, hypotheses, or even full abstracts. Try it out: mssearch.xyz
Streamlit
mssearch.xyz
February 16, 2025 at 7:02 PM
I've been developing a semantic search tool that covers not just bioRxiv and medRxiv, but the entire PubMed database. This means you can search across a massive collection of biomedical research using keywords, questions, hypotheses, or even full abstracts. Try it out: mssearch.xyz
Reposted
not sure what's worse about the DOGE site: unsecured databases, leaking of classified information, or these chart crimes
February 15, 2025 at 1:59 PM
not sure what's worse about the DOGE site: unsecured databases, leaking of classified information, or these chart crimes
Reposted
I was hoping that my first bsky post would be more cheerful. I recently joined NIH (NIEHS) as a PO. I fought hard for this position and was so excited to support health science from a new vantage point… I picked up my life and moved to NC. Unfortunately, my time at NIEHS was short lived.
February 16, 2025 at 3:49 PM
I was hoping that my first bsky post would be more cheerful. I recently joined NIH (NIEHS) as a PO. I fought hard for this position and was so excited to support health science from a new vantage point… I picked up my life and moved to NC. Unfortunately, my time at NIEHS was short lived.
Reposted
Our paper on leveraging large language models for academic conference organization (the AMIA 2024 Informatics Summit) was published today in npj Digital Medicine.
#LLMs
#informatics
www.nature.com/articles/s41...
#LLMs
#informatics
www.nature.com/articles/s41...
Leveraging large language models for academic conference organization - npj Digital Medicine
We piloted using Large Language Models (LLMs) for organizing AMIA 2024 Informatics Summit. LLMs were prompt engineered to develop algorithms for reviewer assignments, group presentations into sessions...
www.nature.com
February 15, 2025 at 1:15 AM
Our paper on leveraging large language models for academic conference organization (the AMIA 2024 Informatics Summit) was published today in npj Digital Medicine.
#LLMs
#informatics
www.nature.com/articles/s41...
#LLMs
#informatics
www.nature.com/articles/s41...
Reposted
My Perspective in @NEJM_AI. AI could distort clinical decision-making in ways that prioritize profit over patient care. Oversight & regulation must go beyond performance metrics alone to address hidden commercial forces that could shape decision support. ai.nejm.org/doi/full/10....
Unseen Commercial Forces Could Undermine Artificial Intelligence Decision Support
Artificial intelligence (AI) is poised to transform health care, yet without robust safeguards, unseen commercial interests could distort care by prioritizing profit over patient well-being. The ph...
ai.nejm.org
February 6, 2025 at 4:15 PM
My Perspective in @NEJM_AI. AI could distort clinical decision-making in ways that prioritize profit over patient care. Oversight & regulation must go beyond performance metrics alone to address hidden commercial forces that could shape decision support. ai.nejm.org/doi/full/10....
Reposted
Excited to have a paper accepted in Nature Portfolio’s npj Digital Medicine today with Yuan Luo, Blanca Himes and Eileen Koski based on our experiences with the AMIA 2024 Informatics Summit.
January 31, 2025 at 5:32 AM
Excited to have a paper accepted in Nature Portfolio’s npj Digital Medicine today with Yuan Luo, Blanca Himes and Eileen Koski based on our experiences with the AMIA 2024 Informatics Summit.
Reposted
Best #Nikolaus 🎅! Our paper on how the 🫁 microenvironment can shape #innate immunity against #viruses is out @sciimmunology.bsky.social This was a herculean effort brilliantly led by @pauljbaker.bsky.social who singlehandedly established the model in the lab during the pandemic. 🧪 #Immunosky 1/9
December 6, 2024 at 10:38 PM
Best #Nikolaus 🎅! Our paper on how the 🫁 microenvironment can shape #innate immunity against #viruses is out @sciimmunology.bsky.social This was a herculean effort brilliantly led by @pauljbaker.bsky.social who singlehandedly established the model in the lab during the pandemic. 🧪 #Immunosky 1/9
Reposted
Incredibly honored to be interviewed in this special issue @naturemethods.bsky.social and have work from the lab highlighted!
Also, thanks for letting me share some thoughts on spatial atlases and where we are as a community to extract meaningful info from the these valuable data resources! 🧪🧬💻
Also, thanks for letting me share some thoughts on spatial atlases and where we are as a community to extract meaningful info from the these valuable data resources! 🧪🧬💻
I could not be more thrilled to announce the Nature Methods @naturemethods.bsky.social Method of the Year is Spatial Proteomics! Please see our editorial as a roadmap to the fantastic content in this special issue! www.nature.com/articles/s41...
Method of the Year 2024: spatial proteomics - Nature Methods
Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.
www.nature.com
December 7, 2024 at 1:57 AM
Incredibly honored to be interviewed in this special issue @naturemethods.bsky.social and have work from the lab highlighted!
Also, thanks for letting me share some thoughts on spatial atlases and where we are as a community to extract meaningful info from the these valuable data resources! 🧪🧬💻
Also, thanks for letting me share some thoughts on spatial atlases and where we are as a community to extract meaningful info from the these valuable data resources! 🧪🧬💻
Reposted
Major crisis with dwindling #Pediatricians and Peds #subspecialists.
#PedsPulm: only 48% of positions, 36% of programs filled. Similar for others.
Need fairer compensation that reflects growing complexity. Not sustainable if pay is 40% of what adult medicine makes.
#Medsky #Pedsky #PedPulmSky
#PedsPulm: only 48% of positions, 36% of programs filled. Similar for others.
Need fairer compensation that reflects growing complexity. Not sustainable if pay is 40% of what adult medicine makes.
#Medsky #Pedsky #PedPulmSky
Percentage of available positions that filled in yesterday’s fellowship match.
December 6, 2024 at 12:29 AM
Major crisis with dwindling #Pediatricians and Peds #subspecialists.
#PedsPulm: only 48% of positions, 36% of programs filled. Similar for others.
Need fairer compensation that reflects growing complexity. Not sustainable if pay is 40% of what adult medicine makes.
#Medsky #Pedsky #PedPulmSky
#PedsPulm: only 48% of positions, 36% of programs filled. Similar for others.
Need fairer compensation that reflects growing complexity. Not sustainable if pay is 40% of what adult medicine makes.
#Medsky #Pedsky #PedPulmSky
I agree
🚨 I am now convinced that "the future belongs to those who own their data, their data science, their machine learning, and therefore their artificial intelligence".
📋 This concluding statement was exposed during my "Eyes Wide Open + AIs Wide Open" keynote this morning at the GenerationAI conf.
📋 This concluding statement was exposed during my "Eyes Wide Open + AIs Wide Open" keynote this morning at the GenerationAI conf.
December 3, 2024 at 2:51 PM
I agree
Reposted
This is an excellent short paper that provides a nice framework for thinking about building the evidence base for the efficacy of AI.
Viewpoint from Manesh Patel and colleagues discusses a clinical framework for applying #AI in health care.
ja.ma/3CIbcgX
ja.ma/3CIbcgX
November 27, 2024 at 4:28 PM
This is an excellent short paper that provides a nice framework for thinking about building the evidence base for the efficacy of AI.
Reposted
🎨 In case anyone need…
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
November 23, 2024 at 3:50 PM
🎨 In case anyone need…
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
Read this detailed account of how Nancy Hopkins and others made progress for #womeninscience The young trainees in my lab had never even heard of the MIT report 😱
November 21, 2024 at 12:14 AM
Read this detailed account of how Nancy Hopkins and others made progress for #womeninscience The young trainees in my lab had never even heard of the MIT report 😱
This may be a relapse and not a fix, but here I am. At least for now.
November 19, 2024 at 2:38 AM
This may be a relapse and not a fix, but here I am. At least for now.