bioRxiv Synthetic Biology
@biorxiv-synthbio.bsky.social
pH-responsive synthetic cells for controlled protein synthesis and release https://www.biorxiv.org/content/10.1101/2025.11.16.688650v1
November 17, 2025 at 2:04 AM
pH-responsive synthetic cells for controlled protein synthesis and release https://www.biorxiv.org/content/10.1101/2025.11.16.688650v1
Reprogrammed SimCells for Antimicrobial Therapy https://www.biorxiv.org/content/10.1101/2025.11.15.688600v1
November 16, 2025 at 3:02 AM
Reprogrammed SimCells for Antimicrobial Therapy https://www.biorxiv.org/content/10.1101/2025.11.15.688600v1
Tuning a Genetic Circuit with Double Negative Feedforward Loops to Approximate Square Waves https://www.biorxiv.org/content/10.1101/2025.11.13.688370v1
November 15, 2025 at 2:02 AM
Tuning a Genetic Circuit with Double Negative Feedforward Loops to Approximate Square Waves https://www.biorxiv.org/content/10.1101/2025.11.13.688370v1
Single-component optogenetic control enables human portrait formation in cells https://www.biorxiv.org/content/10.1101/2025.11.13.688218v1
November 14, 2025 at 4:02 AM
Single-component optogenetic control enables human portrait formation in cells https://www.biorxiv.org/content/10.1101/2025.11.13.688218v1
Conjugation-mediated DNA delivery to the filamentous fungus Ustilago maydis https://www.biorxiv.org/content/10.1101/2025.11.13.688287v1
November 14, 2025 at 3:05 AM
Conjugation-mediated DNA delivery to the filamentous fungus Ustilago maydis https://www.biorxiv.org/content/10.1101/2025.11.13.688287v1
E1: Retrieval-Augmented Protein Encoder Models https://www.biorxiv.org/content/10.1101/2025.11.12.688125v1
November 14, 2025 at 3:05 AM
E1: Retrieval-Augmented Protein Encoder Models https://www.biorxiv.org/content/10.1101/2025.11.12.688125v1
Integrated microdroplet workflow for high-throughput cell-free transcription in double emulsion picoreactors https://www.biorxiv.org/content/10.1101/2025.11.13.688266v1
November 14, 2025 at 2:02 AM
Integrated microdroplet workflow for high-throughput cell-free transcription in double emulsion picoreactors https://www.biorxiv.org/content/10.1101/2025.11.13.688266v1
A funnel-type pipeline for accelerating discovery of tailored designer xylanosomes for efficient arabinoxylan valorization https://www.biorxiv.org/content/10.1101/2025.11.12.687223v1
November 13, 2025 at 4:10 AM
A funnel-type pipeline for accelerating discovery of tailored designer xylanosomes for efficient arabinoxylan valorization https://www.biorxiv.org/content/10.1101/2025.11.12.687223v1
Modular in vivo engineering of the reductive methylaspartate cycles for synthetic CO2 fixation https://www.biorxiv.org/content/10.1101/2025.11.12.688011v1
November 13, 2025 at 3:04 AM
Modular in vivo engineering of the reductive methylaspartate cycles for synthetic CO2 fixation https://www.biorxiv.org/content/10.1101/2025.11.12.688011v1
Harnessing Plasmid Crosstalk in Transcription Factor Mediated Cell-Free Biosensors https://www.biorxiv.org/content/10.1101/2025.11.11.687754v1
November 12, 2025 at 3:07 AM
Harnessing Plasmid Crosstalk in Transcription Factor Mediated Cell-Free Biosensors https://www.biorxiv.org/content/10.1101/2025.11.11.687754v1
Discovery and Functional Characterization of Salinity-Responsive Promoters in Pseudomonas putida KT2440 https://www.biorxiv.org/content/10.1101/2025.11.11.687801v1
November 12, 2025 at 3:07 AM
Discovery and Functional Characterization of Salinity-Responsive Promoters in Pseudomonas putida KT2440 https://www.biorxiv.org/content/10.1101/2025.11.11.687801v1
An Ehrlich-inspired retrobiosynthesis of pharmaceutical scaffolds https://www.biorxiv.org/content/10.1101/2025.11.10.687684v1
November 12, 2025 at 2:04 AM
An Ehrlich-inspired retrobiosynthesis of pharmaceutical scaffolds https://www.biorxiv.org/content/10.1101/2025.11.10.687684v1
Optimizing cytochrome P450 activity for quillaic acid biosynthesis in Saccharomyces cerevisiae https://www.biorxiv.org/content/10.1101/2025.11.09.685466v1
November 11, 2025 at 9:10 PM
Optimizing cytochrome P450 activity for quillaic acid biosynthesis in Saccharomyces cerevisiae https://www.biorxiv.org/content/10.1101/2025.11.09.685466v1
Billion-Scale Deciphering of Human Gene Regulatory Grammar https://www.biorxiv.org/content/10.1101/2025.11.10.687627v1
November 11, 2025 at 3:04 AM
Billion-Scale Deciphering of Human Gene Regulatory Grammar https://www.biorxiv.org/content/10.1101/2025.11.10.687627v1
Designing Convergent Overlapping Genes with Transformer Encoder Models and Lightweight Structural Proxies https://www.biorxiv.org/content/10.1101/2025.11.07.687268v1
November 10, 2025 at 6:05 PM
Designing Convergent Overlapping Genes with Transformer Encoder Models and Lightweight Structural Proxies https://www.biorxiv.org/content/10.1101/2025.11.07.687268v1
Engineering butyrate-producing Lachnospiraceae to treat metabolic disease https://www.biorxiv.org/content/10.1101/2025.11.08.687059v1
November 10, 2025 at 4:07 AM
Engineering butyrate-producing Lachnospiraceae to treat metabolic disease https://www.biorxiv.org/content/10.1101/2025.11.08.687059v1
Two-Year Field Trial of Genetically Engineered American Chestnut Reveals Greater Fungal Blight Tolerance Compared to Wild-Type Full-Sibling Trees https://www.biorxiv.org/content/10.1101/2025.11.07.687213v1
November 9, 2025 at 4:04 AM
Two-Year Field Trial of Genetically Engineered American Chestnut Reveals Greater Fungal Blight Tolerance Compared to Wild-Type Full-Sibling Trees https://www.biorxiv.org/content/10.1101/2025.11.07.687213v1
Genomic Perception Fusion: A Lightweight, Interpretable Kernel for Protein Functional Tuning https://www.biorxiv.org/content/10.1101/2025.11.06.686961v1
November 8, 2025 at 12:04 AM
Genomic Perception Fusion: A Lightweight, Interpretable Kernel for Protein Functional Tuning https://www.biorxiv.org/content/10.1101/2025.11.06.686961v1
Rewiring protein function through genetically encoded oxidative chemistry https://www.biorxiv.org/content/10.1101/2025.11.06.686050v1
November 7, 2025 at 4:12 AM
Rewiring protein function through genetically encoded oxidative chemistry https://www.biorxiv.org/content/10.1101/2025.11.06.686050v1
Cargo-directed assembly of nonviral nucleocapsid with controlled size https://www.biorxiv.org/content/10.1101/2025.11.06.684264v1
November 7, 2025 at 3:06 AM
Cargo-directed assembly of nonviral nucleocapsid with controlled size https://www.biorxiv.org/content/10.1101/2025.11.06.684264v1
Modeling and minimization of dCas9-induced competition in CRISPRi-based genetic circuits https://www.biorxiv.org/content/10.1101/2025.11.05.686856v1
November 6, 2025 at 4:05 AM
Modeling and minimization of dCas9-induced competition in CRISPRi-based genetic circuits https://www.biorxiv.org/content/10.1101/2025.11.05.686856v1
Genetic incorporation of diverse non-canonical amino acids for histidine substitution https://www.biorxiv.org/content/10.1101/2025.11.04.686677v1
November 6, 2025 at 3:04 AM
Genetic incorporation of diverse non-canonical amino acids for histidine substitution https://www.biorxiv.org/content/10.1101/2025.11.04.686677v1
Engineering of Pseudomonas putida KT2440 for Broad-Chain-Length 3-Hydroxy Fatty Acid Biosynthesis https://www.biorxiv.org/content/10.1101/2025.11.04.686531v1
November 5, 2025 at 4:04 AM
Engineering of Pseudomonas putida KT2440 for Broad-Chain-Length 3-Hydroxy Fatty Acid Biosynthesis https://www.biorxiv.org/content/10.1101/2025.11.04.686531v1
Rhodo-Box: a Synthetic Biology Toolbox to Facilitate Metabolic Engineering of Rhodobacter sphaeroides https://www.biorxiv.org/content/10.1101/2025.10.31.685836v1
November 2, 2025 at 5:03 AM
Rhodo-Box: a Synthetic Biology Toolbox to Facilitate Metabolic Engineering of Rhodobacter sphaeroides https://www.biorxiv.org/content/10.1101/2025.10.31.685836v1
PHYCUT: Scalable multiplex CRISPR/Cas9 editing forgenome engineering in the diatom Phaeodactylumtricornutum https://www.biorxiv.org/content/10.1101/2025.10.31.685893v1
November 1, 2025 at 2:03 AM
PHYCUT: Scalable multiplex CRISPR/Cas9 editing forgenome engineering in the diatom Phaeodactylumtricornutum https://www.biorxiv.org/content/10.1101/2025.10.31.685893v1