bioRxiv Cancer Bio
@biorxiv-cancer.bsky.social
Multiplexed CRISPR/Cas9 Editing of Tumor Suppressor Genes Recapitulates Molecular and Morphological Features of High-Risk Endometrial Cancer https://www.biorxiv.org/content/10.1101/2025.11.28.691175v1
December 2, 2025 at 5:06 AM
Multiplexed CRISPR/Cas9 Editing of Tumor Suppressor Genes Recapitulates Molecular and Morphological Features of High-Risk Endometrial Cancer https://www.biorxiv.org/content/10.1101/2025.11.28.691175v1
ALKBH1 drives codon-biased, pro-oncogenic translation and tumor microenvironment remodeling in glioma via tRNA wobble oxidation https://www.biorxiv.org/content/10.1101/2025.11.28.691056v1
December 2, 2025 at 1:49 AM
ALKBH1 drives codon-biased, pro-oncogenic translation and tumor microenvironment remodeling in glioma via tRNA wobble oxidation https://www.biorxiv.org/content/10.1101/2025.11.28.691056v1
The subclonal footprint of pervasive early dissemination in pancreatic cancer https://www.biorxiv.org/content/10.1101/2025.11.27.690823v1
December 2, 2025 at 1:49 AM
The subclonal footprint of pervasive early dissemination in pancreatic cancer https://www.biorxiv.org/content/10.1101/2025.11.27.690823v1
Proteostasis Stress Drives Stem Cell Aging, Clonal Hematopoiesis and Leukemia https://www.biorxiv.org/content/10.1101/2025.11.27.690982v1
December 2, 2025 at 1:49 AM
Proteostasis Stress Drives Stem Cell Aging, Clonal Hematopoiesis and Leukemia https://www.biorxiv.org/content/10.1101/2025.11.27.690982v1
Tissue architecture and immune niches govern ctDNA release in colorectal cancer https://www.biorxiv.org/content/10.1101/2025.11.28.691139v1
December 2, 2025 at 1:48 AM
Tissue architecture and immune niches govern ctDNA release in colorectal cancer https://www.biorxiv.org/content/10.1101/2025.11.28.691139v1
Silylation of hydroxychloroquine enhances autophagy inhibition and antiproliferative activity in breast and pancreatic cancer cells https://www.biorxiv.org/content/10.1101/2025.11.26.690890v1
December 2, 2025 at 12:34 AM
Silylation of hydroxychloroquine enhances autophagy inhibition and antiproliferative activity in breast and pancreatic cancer cells https://www.biorxiv.org/content/10.1101/2025.11.26.690890v1
L-Phenylalanine restriction amplifies boron neutron capture therapy efficacy through increased L-boronophenylalanine uptake and induces activating transcription factor 4 stress response in tumor cell lines https://www.biorxiv.org/content/10.1101/2025.11.27.690635v1
December 2, 2025 at 12:29 AM
L-Phenylalanine restriction amplifies boron neutron capture therapy efficacy through increased L-boronophenylalanine uptake and induces activating transcription factor 4 stress response in tumor cell lines https://www.biorxiv.org/content/10.1101/2025.11.27.690635v1
Dietary Fat Content Influences PanIN Progression and Pancreatic Cancer Development in Mice https://www.biorxiv.org/content/10.1101/2025.11.26.690783v1
December 1, 2025 at 10:47 PM
Dietary Fat Content Influences PanIN Progression and Pancreatic Cancer Development in Mice https://www.biorxiv.org/content/10.1101/2025.11.26.690783v1
DTCFinder: a bench-to-bits toolkit for label-free, whole-spectrum analysis of disseminated and circulating tumor cells in liquid biopsies https://www.biorxiv.org/content/10.1101/2025.11.27.690914v1
December 1, 2025 at 10:47 PM
DTCFinder: a bench-to-bits toolkit for label-free, whole-spectrum analysis of disseminated and circulating tumor cells in liquid biopsies https://www.biorxiv.org/content/10.1101/2025.11.27.690914v1
Deciphering Tumor Microenvironment Dynamics in Tumorigenesis and Lymph Node Metastasis of Esophageal Squamous Cell Carcinoma using Single-Cell RNA Sequencing https://www.biorxiv.org/content/10.1101/2025.11.27.690370v1
December 1, 2025 at 8:46 AM
Deciphering Tumor Microenvironment Dynamics in Tumorigenesis and Lymph Node Metastasis of Esophageal Squamous Cell Carcinoma using Single-Cell RNA Sequencing https://www.biorxiv.org/content/10.1101/2025.11.27.690370v1
Hepatocyte MLKL Drives Obesity-Driven Hepatocellular Carcinoma Progression via Mitochondrial Dysfunction Independent of Necroptosis in MASLD https://www.biorxiv.org/content/10.1101/2025.11.26.690789v1
December 1, 2025 at 3:48 AM
Hepatocyte MLKL Drives Obesity-Driven Hepatocellular Carcinoma Progression via Mitochondrial Dysfunction Independent of Necroptosis in MASLD https://www.biorxiv.org/content/10.1101/2025.11.26.690789v1
A clinical-stage oncology compound selectively targets drug-resistant cancers https://www.biorxiv.org/content/10.1101/2025.11.26.690878v1
December 1, 2025 at 2:48 AM
A clinical-stage oncology compound selectively targets drug-resistant cancers https://www.biorxiv.org/content/10.1101/2025.11.26.690878v1
DYRK1A regulates cancer cell and cancer-associated fibroblast secretomes to foster an immunosuppressive microenvironment in pancreatic cancer https://www.biorxiv.org/content/10.1101/2025.11.26.690756v1
December 1, 2025 at 1:47 AM
DYRK1A regulates cancer cell and cancer-associated fibroblast secretomes to foster an immunosuppressive microenvironment in pancreatic cancer https://www.biorxiv.org/content/10.1101/2025.11.26.690756v1
Collagen I promotes cancer cell survival via amino acid import and mTORC1 activation https://www.biorxiv.org/content/10.1101/2025.11.26.690708v1
December 1, 2025 at 1:47 AM
Collagen I promotes cancer cell survival via amino acid import and mTORC1 activation https://www.biorxiv.org/content/10.1101/2025.11.26.690708v1
Loss of ESE3/EHF is sufficient to promote cell plasticity, transformation and androgen-independent status in the early stage of prostate carcinogenesis. https://www.biorxiv.org/content/10.1101/2025.11.26.690649v1
November 30, 2025 at 9:46 PM
Loss of ESE3/EHF is sufficient to promote cell plasticity, transformation and androgen-independent status in the early stage of prostate carcinogenesis. https://www.biorxiv.org/content/10.1101/2025.11.26.690649v1
Increasing TET expression and 5-hydroxymethylcytosine formation by a carbocyclic 5-aza-2'-deoxy-cytidine antimetabolite https://www.biorxiv.org/content/10.1101/2025.11.26.690736v1
November 30, 2025 at 7:46 PM
Increasing TET expression and 5-hydroxymethylcytosine formation by a carbocyclic 5-aza-2'-deoxy-cytidine antimetabolite https://www.biorxiv.org/content/10.1101/2025.11.26.690736v1
UHRF1 Overexpression Generates Distinct Senescent States with Different Tp53 Dependencies https://www.biorxiv.org/content/10.1101/2025.11.26.690503v1
November 30, 2025 at 7:46 PM
UHRF1 Overexpression Generates Distinct Senescent States with Different Tp53 Dependencies https://www.biorxiv.org/content/10.1101/2025.11.26.690503v1
Integrated proteogenomics uncovers ancestry-specific and shared molecular drivers in localized prostate cancer https://www.biorxiv.org/content/10.1101/2025.11.28.691220v1
November 30, 2025 at 4:46 AM
Integrated proteogenomics uncovers ancestry-specific and shared molecular drivers in localized prostate cancer https://www.biorxiv.org/content/10.1101/2025.11.28.691220v1
Identifying phenotype-genotype-function coupling in 3D organoid imaging using Shape, Appearance and Motion Phenotype Observation Tool (SPOT) https://www.biorxiv.org/content/10.1101/2025.11.28.691111v1
November 30, 2025 at 3:47 AM
Identifying phenotype-genotype-function coupling in 3D organoid imaging using Shape, Appearance and Motion Phenotype Observation Tool (SPOT) https://www.biorxiv.org/content/10.1101/2025.11.28.691111v1
ATHENA: A deep learning-based AI for functional prediction of genomic mutations and synergistic vulnerabilities in prostate cancer https://www.biorxiv.org/content/10.1101/2025.11.26.690813v1
November 30, 2025 at 3:47 AM
ATHENA: A deep learning-based AI for functional prediction of genomic mutations and synergistic vulnerabilities in prostate cancer https://www.biorxiv.org/content/10.1101/2025.11.26.690813v1
Neuronal innervation of breast cancer promotes metastatic dissemination https://www.biorxiv.org/content/10.1101/2025.11.25.690523v1
November 29, 2025 at 4:47 PM
Neuronal innervation of breast cancer promotes metastatic dissemination https://www.biorxiv.org/content/10.1101/2025.11.25.690523v1
Therapy-induced PSMA2 Sensitizes Prostate Cancer Cells to Residual Androgen and Promotes Neuroendocrine Lineage Transformation https://www.biorxiv.org/content/10.1101/2025.11.25.690552v1
November 29, 2025 at 4:47 PM
Therapy-induced PSMA2 Sensitizes Prostate Cancer Cells to Residual Androgen and Promotes Neuroendocrine Lineage Transformation https://www.biorxiv.org/content/10.1101/2025.11.25.690552v1
Antibody-Protein L Functionalized Microparticles for Detection of Surface Markers in Heterogeneous Colorectal Lesions https://www.biorxiv.org/content/10.1101/2025.11.25.690572v1
November 29, 2025 at 4:46 PM
Antibody-Protein L Functionalized Microparticles for Detection of Surface Markers in Heterogeneous Colorectal Lesions https://www.biorxiv.org/content/10.1101/2025.11.25.690572v1
An integrated platform for high-throughput phenospace learning of 3D multilineage organoid systems https://www.biorxiv.org/content/10.1101/2025.11.27.690952v1
November 29, 2025 at 8:46 AM
An integrated platform for high-throughput phenospace learning of 3D multilineage organoid systems https://www.biorxiv.org/content/10.1101/2025.11.27.690952v1
Mammary Fibroblasts Secrete Damage Associated Molecular Patterns through Extracellular Vesicles in Response to Ionizing Radiation https://www.biorxiv.org/content/10.1101/2025.11.25.690532v1
November 29, 2025 at 2:48 AM
Mammary Fibroblasts Secrete Damage Associated Molecular Patterns through Extracellular Vesicles in Response to Ionizing Radiation https://www.biorxiv.org/content/10.1101/2025.11.25.690532v1