For my first Bluesky post, I'm excited to share that the first paper of my PhD work is out! In this work, we focus on how condensates in the cell nucleus respond to mechanical deformation during cell confined migration, a process involved in cancer cell metastasis. (1/3)

We showed that local chromatin heterogeneity tunes condensation propensity, revealing drastic difference of condensate behavior across the advancing vs. the trailing half of the same cell! Green: H2B-mGFP (chromatin), Magenta: miRFP670-53BP1 (condensates). (2/3)