The amazing projects wait for curious minds! From fly genetics to transcriptional kinetics, from whole-embryo single-cell atlases to the charming chromatin microscopy!
Welcoming at @stockholm-uni.bsky.social
#epigenetics #chromatin #DevBio

Using PRO-seq and CUT&Tag, we found that CBP activates zygotic genes in two steps:
- It helps recruit RNA Pol II to promoters without requiring catalytic activity.
- Its catalytic acetyltransferase function then triggers pause release.

We show that transcription factor Zelda is required for CBP recruitment, but CBP is dispensable for Zelda pioneer factor function. Instead, CBP catalytic activity is essential for zygotic genome activation and successful gastrulation.

The CBP project will be out in Molecular Cell very soon—don’t miss it if you're into ZGA, transcription regulation, and histone acetyltransferases! The second project is a great collaboration with @mardzix.bsky.social and part of the @scentinel.bsky.social consortium #epigenetics #chromatin #devbio

The superb conference in EMBL Epigenetics&Chromatin is over. Fantastic talks, a lot of incredible research in the poster section. I was glad to present two of my PhD projects: catalytic and non-catalytic function of CBP/p300 in development, and single-cell epigenetic landscapes of Drosophila embryo.