Matt Begley
@biochembatman.bsky.social
GSD dad, diver, baker, Biochem PhD, Virology postdoc. Views my own.
Reposted by Matt Begley
Structural and functional characterisation of the Crimean-Congo Haemorrhagic Fever Virus RNA Dependent RNA Polymerase www.biorxiv.org/content/10.1101/2025.10.21.683639v1 #cryoem
October 22, 2025 at 7:10 AM
Structural and functional characterisation of the Crimean-Congo Haemorrhagic Fever Virus RNA Dependent RNA Polymerase www.biorxiv.org/content/10.1101/2025.10.21.683639v1 #cryoem
Reposted by Matt Begley
Out in Science Advances: Our #cryoEM structure of HFTV1, a virus infecting the halophile #archaea. *First full atomic structure (containing all structural proteins) of any tailed virus!* Congrats and thanks to all co-authors and our fantastic collaborators! www.science.org/doi/10.1126/...
Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail
This structure of an archaeal tailed virus (arTV) provides detailed insights into arTV assembly and infection mechanisms.
www.science.org
October 6, 2025 at 11:31 AM
Out in Science Advances: Our #cryoEM structure of HFTV1, a virus infecting the halophile #archaea. *First full atomic structure (containing all structural proteins) of any tailed virus!* Congrats and thanks to all co-authors and our fantastic collaborators! www.science.org/doi/10.1126/...
Great talk at #PS39 by @berlowlab.bsky.social!
June 28, 2025 at 6:00 PM
Great talk at #PS39 by @berlowlab.bsky.social!
Reposted by Matt Begley
Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪
www.richmondscientific.com/how-a-discov...
www.richmondscientific.com/how-a-discov...
How a discovery in Yellowstone National Park led to the development of PCR - Richmond Scientific
A discovery in Yellowstone National Park led to the development of PCR, the gold-standard COVID-19 tests used to fight the global pandemic.
www.richmondscientific.com
June 8, 2025 at 9:09 PM
Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪
www.richmondscientific.com/how-a-discov...
www.richmondscientific.com/how-a-discov...
Reposted by Matt Begley
It’s shocking to see life-saving work paused like this! #DiseaseResearch #PublicHealth #ScienceMatters #HHS #NIH #IRF #NIAID #Ebola #USPol
RFK Jr.'s HHS Orders Lab Studying Deadly Infectious Diseases to Stop Research
NIAID's Integrated Research Facility is one of the few federal facilities charged with studying Ebola. Tuesday afternoon, all of its work was put on indefinite pause by Robert F. Kennedy Jr.'s departm...
www.wired.com
April 30, 2025 at 10:21 PM
It’s shocking to see life-saving work paused like this! #DiseaseResearch #PublicHealth #ScienceMatters #HHS #NIH #IRF #NIAID #Ebola #USPol
Reposted by Matt Begley
A structure-based mechanism for initiation of AP-3 coated vesicle formation pubmed.ncbi.nlm.nih.gov/39705307/
December 21, 2024 at 7:40 PM
A structure-based mechanism for initiation of AP-3 coated vesicle formation pubmed.ncbi.nlm.nih.gov/39705307/