7/ 🔗 “A single-cell transposable element atlas of human cell identity” Cell Reports Methods, 2025. doi.org/10.1016/j.cr...

TY: @bhavyasighs.bsky.social @hamarillo.bsky.social @3rduarte.bsky.social @weillcornell.bsky.social

🔄 RT to share with colleagues in #singlecell and #genomics!

Read the full story here:
doi.org/10.1016/j.is...

A special congratulations to FIRST AUTHOR @bhavyasighs.bsky.social

Thanks to an amazing team and collaborators! @ecesarman.bsky.social @heymannjonas.bsky.social @hamarillo.bsky.social @weillcornell.bsky.social

#lymphoma #HERV #bioinformatics

Bottom line: HERV expression can uncover hidden lymphoma biology 🧫

🧬 Inform classification
🧬 Refine prognosis
🧬 Suggest new therapeutic targets

A new frontier for cancer retrotranscriptomics!
7/

Importantly, HERV-based subtypes predict prognosis.

Clusters enriched for plasma cell-like signatures had the poorest survival — a finding invisible in gene-only classifications.

6/

In DLBCL, we identified 7 distinct HERV-driven subtypes, refining the traditional 3-subtype COO model.

Some "unclassified" DLBCLs actually fit into new HERV-defined groups — with distinct survival outcomes! 📉📈

5/

Findings:

- Healthy B-cells show dynamic HERV activity during differentiation.
- Lymphomas retain HERV signatures from their cell of origin (COO).
- BL subtypes cluster by EBV status better with HERVs than with genes!

4/

We created the first locus-specific map of HERV activity in:
- Healthy B cells (Naïve, Memory, Germinal Center subtypes)
- Diffuse large B-cell lymphoma (DLBCL)
- Follicular lymphoma (FL)
- Burkitt lymphoma (BL)
🎯 Using RNAseq + #Telescope quantification.

3/

Endogenous retroelements (EREs), like HERVs, make up ~8% of the human genome. Their expression is often overlooked — but we found they hold key information about B-cell identity, both in healthy germinal centers and in malignancy!

2/

Read about her work on HERV expression in B-cell lymphomas here 👇
www.cell.com/iscience/ful...

Amazing!! Congratulations, @ananya-p.bsky.social!!!