@Bernard-S-Lopez.bsky.social
@bernard-s-lopez.bsky.social
Research Director at CNRS. Cochin Institute. Genome Stability instability, DNA repair and recombination, replication stress.
Nanomaterials, Clay mineral, silicates
Nanomaterials, Clay mineral, silicates
Plot twist: homologous recombination actually promotes the development of cancer!
This discussion has been started in the hope that it will be useful, see the link:
doi.org/10.1038/s413...
This discussion has been started in the hope that it will be useful, see the link:
doi.org/10.1038/s413...
RAD51-mediated homologous recombination is a pro-tumour driver pathway - Oncogene
Oncogene - RAD51-mediated homologous recombination is a pro-tumour driver pathway
doi.org
September 24, 2025 at 2:50 PM
Plot twist: homologous recombination actually promotes the development of cancer!
This discussion has been started in the hope that it will be useful, see the link:
doi.org/10.1038/s413...
This discussion has been started in the hope that it will be useful, see the link:
doi.org/10.1038/s413...
The LoL-DDR (doi.org/10.1038/s414...)
is dysregulated in transformed cell lines (doi.org/10.1038/s415...)
is dysregulated in transformed cell lines (doi.org/10.1038/s415...)
A noncanonical response to replication stress protects genome stability through ROS production, in an adaptive manner - Cell Death & Differentiation
Cell Death & Differentiation - A noncanonical response to replication stress protects genome stability through ROS production, in an adaptive manner
doi.org
June 20, 2025 at 10:27 AM
The LoL-DDR (doi.org/10.1038/s414...)
is dysregulated in transformed cell lines (doi.org/10.1038/s415...)
is dysregulated in transformed cell lines (doi.org/10.1038/s415...)
The hyper-activation of DNA double-strand break repair by the AKT1/PKB oncogene generates genetic instability.
(A new role for the oncogene AKT1: the phosphorylation of MRE11).
academic.oup.com/nar/article-...
(A new role for the oncogene AKT1: the phosphorylation of MRE11).
academic.oup.com/nar/article-...
Genome rearrangements induced by the stimulation of end-joining of DNA double strand breaks through multiple phosphorylation of MRE11 by the kinase PKB/AKT1
Abstract. Genetic instability is a major hazard threatening the fate of cells and ultimately of organisms. DNA double-strand break (DSB) is a highly toxic
academic.oup.com
June 11, 2025 at 12:24 PM
The hyper-activation of DNA double-strand break repair by the AKT1/PKB oncogene generates genetic instability.
(A new role for the oncogene AKT1: the phosphorylation of MRE11).
academic.oup.com/nar/article-...
(A new role for the oncogene AKT1: the phosphorylation of MRE11).
academic.oup.com/nar/article-...
Reposted by @Bernard-S-Lopez.bsky.social
What RNA polymerase gets up to in the genome and how mutations happen! Just out in Nature! Many thanks to many collaborators & congrats 1st author Jingjing Liu! www.nature.com/articles/s41...
February 21, 2025 at 4:20 PM
What RNA polymerase gets up to in the genome and how mutations happen! Just out in Nature! Many thanks to many collaborators & congrats 1st author Jingjing Liu! www.nature.com/articles/s41...