Bede Constantinides
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bede.im
Bede Constantinides
@bede.im
Interested in infectious disease informatics. Research fellow at the University of Birmingham with @articnetwork.bsky.social. Also cycling, photography, active travel. https://bede.im
That favourite burger place of yours…
ratings.food.gov.uk/business/269...
December 9, 2025 at 8:40 AM
Great to meet IRL! Thanks for your talk and chats with us in Birmingham too
December 9, 2025 at 8:36 AM
Yes and it's brilliant albeit expensive. Being speculative it works better on some files than others, so tricky to benchmark.
December 8, 2025 at 8:17 AM
And forthcoming mim index support will enable multi gigabase/sec fastq.gz throughput on large multicore systems bsky.app/profile/curi...

www.biorxiv.org/content/10.1...
December 8, 2025 at 12:01 AM
zlib-rs (@trifectatech.bsky.social) provides these gz decomp gains, which presumably will be used by uutils/coreutils if not already? Hope so!
December 7, 2025 at 11:36 PM
Thank you! So pleased you're finding it useful. Let me know if you or your students have suggestions for how it could be improved.
December 4, 2025 at 9:30 AM
Are you after only reads meeting strict alignment-based scoring criteria, or would a relative threshold of kmer hits suffice? LexicMap sounds promising for the former. The latter is what Deacon is built for – it indexes at about 0.2G/s and filters at 1.5Gbp/s on my laptop.
December 2, 2025 at 10:07 PM
Blissfully ignorant over here
November 13, 2025 at 5:34 PM