This work was carried out by 6
@weareeiu.bsky.social students including @emmanuel-adusah.bsky.social #PUI #proudPI

Our work serves as a crucial reminder to always thoroughly validate your #chemicaltools within each specific experimental context. Assuming specificity, as often happens with FDA for CES2 can lead to misinterpretations. Read the paper at: www.sciencedirect.com/science/arti...

We also demonstrate that FDA may be suitable for studying CES2 when CES2 is the primary hydrolase, such as overexpression models.

Many researchers currently use FDA to study CES2, without the necessary validation. Our work shows that while FDA prefers CES2 over CES1 in vitro, it doesn't specifically report on CES2 in complex biological systems like HepG2 cells, where other #hydrolases can interfere.

NSF addresses this in the broader impacts evaluation of grant applications. Adapting the proposed work/a portion of the work to an outreach project is a common approach to demonstrate broader impacts and can have a portion of the budget associated with it.

Just got the same error when using Login.gov to log in

I may have some interested students