Brian Carrick
@bcarrick.bsky.social
Shurl and Kay Curci Fellow of the Life Sciences Research Foundation | Postdoc scientist with Lori Passmore at the MRC LMB | Biochemistry PhD with Judith Kimble and Marvin Wickens | Lover of all things RNA.
The latest from our group (@lapassmore.bsky.social)! Congrats to James and the rest of the authors!
Phosphorylation-dependent tuning of mRNA deadenylation rates
www.nature.com/articles/s41...
Phosphorylation-dependent tuning of mRNA deadenylation rates
www.nature.com/articles/s41...
Phosphorylation-dependent tuning of mRNA deadenylation rates - Nature Structural & Molecular Biology
Stowell et al. show that the intrinsically disordered region (IDR) of Puf3 binds the Ccr4–Not deadenylase complex using an extended interface. Phosphorylation of the IDR regulates the interaction to t...
www.nature.com
November 3, 2025 at 12:45 PM
The latest from our group (@lapassmore.bsky.social)! Congrats to James and the rest of the authors!
Phosphorylation-dependent tuning of mRNA deadenylation rates
www.nature.com/articles/s41...
Phosphorylation-dependent tuning of mRNA deadenylation rates
www.nature.com/articles/s41...
I'm very excited that I have been elected as a Research Fellow at Clare Hall, University of Cambridge (@clarehallcambridge.bsky.social). It's a pleasure to join such a great community!
www.clarehall.cam.ac.uk/directory/br...
www.clarehall.cam.ac.uk/directory/br...
Brian Carrick - Clare Hall
Dr Brian Carrick Dr Brian Carrick is a postdoctoral researcher at the MRC Laboratory of Molecular Biology (LMB) in the group of Dr Lori Passmore, where he studies how messenger RNAs (mRNAs) are regula...
www.clarehall.cam.ac.uk
October 1, 2025 at 4:23 PM
I'm very excited that I have been elected as a Research Fellow at Clare Hall, University of Cambridge (@clarehallcambridge.bsky.social). It's a pleasure to join such a great community!
www.clarehall.cam.ac.uk/directory/br...
www.clarehall.cam.ac.uk/directory/br...
It was great to be able to present my PhD work at #EMBLProtein! Thanks to the organizers for the opportunity.
September 6, 2025 at 7:27 PM
It was great to be able to present my PhD work at #EMBLProtein! Thanks to the organizers for the opportunity.
Great start to the EMBL translation control meeting with a keynote from @lapassmore.bsky.social. Excited for all the science to come. #EMBLProtein
September 3, 2025 at 6:15 PM
Great start to the EMBL translation control meeting with a keynote from @lapassmore.bsky.social. Excited for all the science to come. #EMBLProtein
Incredibly honored to be a Shurl and Kay Curci Fellow of the Life Sciences Research Foundation. Thanks to Marv and Judith for their support during my PhD and @lapassmore.bsky.social for her backing and mentorship in my postdoc work.
lsrf.org/current-fell...
lsrf.org/current-fell...
August 1, 2025 at 1:37 PM
Incredibly honored to be a Shurl and Kay Curci Fellow of the Life Sciences Research Foundation. Thanks to Marv and Judith for their support during my PhD and @lapassmore.bsky.social for her backing and mentorship in my postdoc work.
lsrf.org/current-fell...
lsrf.org/current-fell...
Reposted by Brian Carrick
A fun collaboration with @rasilab.bsky.social led by Rachael Bakker.
We used an RNA base editor to analyze at scale how substitutions within an RNA or RNA-binding protein affect binding.
doi.org/10.1101/2025...
We used an RNA base editor to analyze at scale how substitutions within an RNA or RNA-binding protein affect binding.
doi.org/10.1101/2025...
Excited to share the work of postdoc Rachael Bakker in collaboration with @lapointelab.bsky.social!
We show that RNA base editors can be repurposed for deep mutational scanning of RNA-RBP interactions at scale both in vitro and in vivo.
www.biorxiv.org/content/10.1...
We show that RNA base editors can be repurposed for deep mutational scanning of RNA-RBP interactions at scale both in vitro and in vivo.
www.biorxiv.org/content/10.1...
Deaminase-based RNA recording enables high throughput mutational profiling of protein-RNA interactions
Protein-RNA interactions govern nearly every aspect of RNA metabolism and are frequently dysregulated in disease. While individual protein residues and RNA nucleotides critical for these interactions ...
www.biorxiv.org
May 2, 2025 at 1:05 AM
A fun collaboration with @rasilab.bsky.social led by Rachael Bakker.
We used an RNA base editor to analyze at scale how substitutions within an RNA or RNA-binding protein affect binding.
doi.org/10.1101/2025...
We used an RNA base editor to analyze at scale how substitutions within an RNA or RNA-binding protein affect binding.
doi.org/10.1101/2025...
Happy to see this work published in RNA, and thanks to the editors for the interview/Meet the First Author Feature! Surprisingly, we found that mutating an RNA binding protein's ability to bind RNA did not remove all biological function. #RNAsky #RNAbiology.
rnajournal.cshlp.org/content/31/5...
rnajournal.cshlp.org/content/31/5...
The PUF RNA-binding protein, FBF-2, maintains stem cells without binding to RNA
A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms
rnajournal.cshlp.org
April 16, 2025 at 3:19 PM
Happy to see this work published in RNA, and thanks to the editors for the interview/Meet the First Author Feature! Surprisingly, we found that mutating an RNA binding protein's ability to bind RNA did not remove all biological function. #RNAsky #RNAbiology.
rnajournal.cshlp.org/content/31/5...
rnajournal.cshlp.org/content/31/5...
It was great working with Chen Qiu, Traci Hall, and all the other authors on this project! Using a combination of structural, biophysical, and in vivo stem cell analyses, we investigated how an RBP and a partner regulate adjacent binding elements in a critical RNA.
#RNAsky #RNAbiology
rdcu.be/d5pER
#RNAsky #RNAbiology
rdcu.be/d5pER
A higher order PUF complex is central to regulation of C. elegans germline stem cells
Nature Communications - PUF proteins, conserved stem cell regulators, maintain germline stem cells with partner proteins in nematodes. Here, authors discover a complex of two FBF-2 PUF proteins and...
rdcu.be
January 3, 2025 at 3:48 PM
It was great working with Chen Qiu, Traci Hall, and all the other authors on this project! Using a combination of structural, biophysical, and in vivo stem cell analyses, we investigated how an RBP and a partner regulate adjacent binding elements in a critical RNA.
#RNAsky #RNAbiology
rdcu.be/d5pER
#RNAsky #RNAbiology
rdcu.be/d5pER
I’m excited to share this story. We found that mutating an RNA binding protein’s ability to bind RNA did not remove all biological function, but when combined with a mutation that affects protein interactions, the RBP no longer functioned.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The PUF RNA-binding protein, FBF-2, maintains stem cells without binding to RNA
Like all canonical PUF proteins, C. elegans FBF-2 binds to specific RNAs via tripartite recognition motifs (TRMs). Here we report that an FBF-2 mutant protein that cannot bind to RNA, is nonetheless b...
www.biorxiv.org
October 26, 2024 at 11:42 AM
I’m excited to share this story. We found that mutating an RNA binding protein’s ability to bind RNA did not remove all biological function, but when combined with a mutation that affects protein interactions, the RBP no longer functioned.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
First Bluesky post, and I'm so excited to share our latest work, online today! We found a protein-protein interaction interface on a Pum/Puf protein mediates binding to a specific subset of RNA targets, and in turn affects only one of its functions in stem cells. 1/2
www.cell.com/developmenta...
www.cell.com/developmenta...
January 29, 2024 at 4:27 PM
First Bluesky post, and I'm so excited to share our latest work, online today! We found a protein-protein interaction interface on a Pum/Puf protein mediates binding to a specific subset of RNA targets, and in turn affects only one of its functions in stem cells. 1/2
www.cell.com/developmenta...
www.cell.com/developmenta...