Barbieri Mariano PhD
@barbierimarianophd.bsky.social
Physicist modelling the complexity of eukaryotic cell's nucleus. University Medical Centre Göttingen
Reposted by Barbieri Mariano PhD
Last week we attended a fantastic meeting of the SPP2191 and GBM Compact on Condensates!
Congrats to members of the Dormann Lab, Yelyzaveta Zadorozhna and Fatmanur Tiryaki, for giving great talks, and to Saskia Hutten for winning a poster award 🎉!
@spp2191.bsky.social
@sfb1551.bsky.social
Congrats to members of the Dormann Lab, Yelyzaveta Zadorozhna and Fatmanur Tiryaki, for giving great talks, and to Saskia Hutten for winning a poster award 🎉!
@spp2191.bsky.social
@sfb1551.bsky.social
📢 Registration is open for the GBM Compact: Focus on Condensate Biology & SPP2191 Satellite Meeting! This is sure to be an incredible event diving into the latest in phase separation research with leading scientists.
📍 Frankfurt am Main
📅 Sept 16–19, 2025
🌐 shorturl.at/ZGQch
@gbmev.bsky.social
📍 Frankfurt am Main
📅 Sept 16–19, 2025
🌐 shorturl.at/ZGQch
@gbmev.bsky.social
September 23, 2025 at 8:16 PM
Last week we attended a fantastic meeting of the SPP2191 and GBM Compact on Condensates!
Congrats to members of the Dormann Lab, Yelyzaveta Zadorozhna and Fatmanur Tiryaki, for giving great talks, and to Saskia Hutten for winning a poster award 🎉!
@spp2191.bsky.social
@sfb1551.bsky.social
Congrats to members of the Dormann Lab, Yelyzaveta Zadorozhna and Fatmanur Tiryaki, for giving great talks, and to Saskia Hutten for winning a poster award 🎉!
@spp2191.bsky.social
@sfb1551.bsky.social
Reposted by Barbieri Mariano PhD
The announcement that the 2025 Keio prize for Medical Science goes to @virusesimmunity.bsky.social and @brangwynnelab.bsky.social Brangwynne. www.ms-fund.keio.ac.jp/en/prize/ Congratulations to the masters for this well deserved honor. It is gratifying when true quality is recognized.
www.ms-fund.keio.ac.jp
September 18, 2025 at 11:48 AM
The announcement that the 2025 Keio prize for Medical Science goes to @virusesimmunity.bsky.social and @brangwynnelab.bsky.social Brangwynne. www.ms-fund.keio.ac.jp/en/prize/ Congratulations to the masters for this well deserved honor. It is gratifying when true quality is recognized.
Reposted by Barbieri Mariano PhD
"In our view, it [hexanediol] should thus be avoided and not be used as evidence for the formation of an assembly via phase separation or the fluid-like nature of a condensate in vitro or in vivo." doi.org/10.1038/s414...
Current practices in the study of biomolecular condensates: a community comment - Nature Communications
The realization that the cell is abundantly compartmentalized into biomolecular condensates has opened new opportunities for understanding the physics and chemistry underlying many cellular processes1...
doi.org
August 21, 2025 at 3:38 PM
"In our view, it [hexanediol] should thus be avoided and not be used as evidence for the formation of an assembly via phase separation or the fluid-like nature of a condensate in vitro or in vivo." doi.org/10.1038/s414...
Reposted by Barbieri Mariano PhD
EpiSci - 🧬 - 🧪
Specialised super-enhancer networks in stem cells and neurons
www.biorxiv.org/content/10.1...
Specialised super-enhancer networks in stem cells and neurons
www.biorxiv.org/content/10.1...
www.biorxiv.org
August 18, 2025 at 7:10 AM
EpiSci - 🧬 - 🧪
Specialised super-enhancer networks in stem cells and neurons
www.biorxiv.org/content/10.1...
Specialised super-enhancer networks in stem cells and neurons
www.biorxiv.org/content/10.1...
Reposted by Barbieri Mariano PhD
Establishment of chromatin architecture interplays with embryo hypertranscription
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com
August 15, 2025 at 8:54 AM
Establishment of chromatin architecture interplays with embryo hypertranscription
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Barbieri Mariano PhD
EpiSci - 🧬 - 🧪 - The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate - Nature Cell Biology
Marin et al. report the role of lamin proteins and the lamin B receptor (LBR) in chromatin positioning at the nuclear periphery. Knockout of all lamins and LBR in mouse embryonic stem cells leads to h...
www.nature.com
July 23, 2025 at 1:53 PM
EpiSci - 🧬 - 🧪 - The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Barbieri Mariano PhD
NKX2-1 drives neuroendocrine transdifferentiation of prostate cancer via epigenetic and 3D chromatin remodeling
www.nature.com/articles/s41...
www.nature.com/articles/s41...
NKX2-1 drives neuroendocrine transdifferentiation of prostate cancer via epigenetic and 3D chromatin remodeling - Nature Genetics
Single-cell RNA and assay for transposase-accessible chromatin sequencing in isogenic prostate adenocarcinoma cells undergoing neuroendocrine transition identify dynamic changes in chromatin and trans...
www.nature.com
July 23, 2025 at 9:09 AM
NKX2-1 drives neuroendocrine transdifferentiation of prostate cancer via epigenetic and 3D chromatin remodeling
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Barbieri Mariano PhD
No new genes needed to fly - just rewire what you have! 🦇🧬
Great new paper from the labs of @fany-real.bsky.social @stemundi.bsky.social @dariloops.bsky.social
doi.org/10.1038/s415...
#EvoDevo #SingleCell #BatWings
Great new paper from the labs of @fany-real.bsky.social @stemundi.bsky.social @dariloops.bsky.social
doi.org/10.1038/s415...
#EvoDevo #SingleCell #BatWings
July 16, 2025 at 1:49 PM
No new genes needed to fly - just rewire what you have! 🦇🧬
Great new paper from the labs of @fany-real.bsky.social @stemundi.bsky.social @dariloops.bsky.social
doi.org/10.1038/s415...
#EvoDevo #SingleCell #BatWings
Great new paper from the labs of @fany-real.bsky.social @stemundi.bsky.social @dariloops.bsky.social
doi.org/10.1038/s415...
#EvoDevo #SingleCell #BatWings
Reposted by Barbieri Mariano PhD
How do transcription compartments form — and does phase separation drive gene expression? I enjoyed discussing these questions with @akispapantonis.bsky.social a lot, and we put our thoughts together for @naturerevgenet.bsky.social, now out at rdcu.be/erP1u
June 19, 2025 at 6:28 PM
How do transcription compartments form — and does phase separation drive gene expression? I enjoyed discussing these questions with @akispapantonis.bsky.social a lot, and we put our thoughts together for @naturerevgenet.bsky.social, now out at rdcu.be/erP1u
Reposted by Barbieri Mariano PhD
Liquid-liquid phase separation of HP1? Not in our mouse fibroblasts… This paper by the Fabian Erdel group offers a fresh perspective on how this can be reconciled with seemingly conflicting reports: The phase separation propensity of HP1 decreases from yeast → fly → mouse. doi.org/10.1038/s414...
July 11, 2025 at 5:35 AM
Liquid-liquid phase separation of HP1? Not in our mouse fibroblasts… This paper by the Fabian Erdel group offers a fresh perspective on how this can be reconciled with seemingly conflicting reports: The phase separation propensity of HP1 decreases from yeast → fly → mouse. doi.org/10.1038/s414...