Ward D
@bakkerwd.bsky.social
bioinfocore@mpi-ie. Fond of viruses, bioinformatics, and NGS. The order might differ depending on my mood. Opinions are my own.
Reposted by Ward D
Today, the #SnakemakeHackathon2025 at @cern.bsky.social has ended with the release of Snakemake 9.0! Huge thanks to the amazing participants and all organizers! In total there were 19 new releases within the ecosystem, including hundreds of new features and bug fixes for Snakemake and its plugins!
March 14, 2025 at 10:11 PM
Today, the #SnakemakeHackathon2025 at @cern.bsky.social has ended with the release of Snakemake 9.0! Huge thanks to the amazing participants and all organizers! In total there were 19 new releases within the ecosystem, including hundreds of new features and bug fixes for Snakemake and its plugins!
Reposted by Ward D
An exciting first day of the #SnakemakeHackathon2025 at @cern.bsky.social is ending now. I have already merged several pull requests and many very productive teams have formed!
March 10, 2025 at 4:52 PM
An exciting first day of the #SnakemakeHackathon2025 at @cern.bsky.social is ending now. I have already merged several pull requests and many very productive teams have formed!
Reposted by Ward D
Nucleosome fibre topology guides transcription factor binding to enhancers www.nature.com/articles/s41...
▶️motif recognition on mononucleosomes affects only an individual TF binding
▶️When bound together, TFs act cooperatively or competitively to target nucleosome arrays with defined 3D organization
▶️motif recognition on mononucleosomes affects only an individual TF binding
▶️When bound together, TFs act cooperatively or competitively to target nucleosome arrays with defined 3D organization
December 18, 2024 at 6:53 PM
Nucleosome fibre topology guides transcription factor binding to enhancers www.nature.com/articles/s41...
▶️motif recognition on mononucleosomes affects only an individual TF binding
▶️When bound together, TFs act cooperatively or competitively to target nucleosome arrays with defined 3D organization
▶️motif recognition on mononucleosomes affects only an individual TF binding
▶️When bound together, TFs act cooperatively or competitively to target nucleosome arrays with defined 3D organization
Reposted by Ward D
Another preprint from the lab and a collaboration with Miriam Schmidts and her lab from Uniklinik_Fr pediatrics. This work was carried out mostly by fantastic MD MOTIVATE student Henrike Berns. Funded by @dfgpublic.bsky.social @cibss.bsky.social and SFB1453_NephGen.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A homozygous human WNT11 loss-of-function variant associated with laterality, heart and renal defects
Wnt signaling plays important roles during vertebrate development, including left-right axis specification as well as heart and kidney organogenesis. We identified a homozygous human WNT11 variant in ...
www.biorxiv.org
November 17, 2024 at 4:38 PM
Another preprint from the lab and a collaboration with Miriam Schmidts and her lab from Uniklinik_Fr pediatrics. This work was carried out mostly by fantastic MD MOTIVATE student Henrike Berns. Funded by @dfgpublic.bsky.social @cibss.bsky.social and SFB1453_NephGen.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...