Inhibiting endogenous PAK4 recruitment to the junctions disrupts barrier function, implicating PAK4 and Afadin as critical partners in vertex remodeling to preserve tissue integrity.

Inhibiting PAK4 disrupts tissue packing and compromises junctional continuity.
This video highlights impaired rosette resolution in PAK4 inhibitor treated embryos.

Our study sheds new light on how p21-activated kinase 4; PAK4 is recruited to epithelial junctions by Afadin, drives dynamic vertex remodeling in both cells and embryos.

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A quick introduction to Miller lab shenanigans 🐸😄 @umichlawlib.bsky.social
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