@avorobieva.bsky.social
Very proud to share the first-author work from my first PhD student, Giacomo Pedrelli 🎉. He combined cell-free expression and computational design to explore how transmembrane β-barrels fold – and what that means for designing them from scratch.
www.biorxiv.org/content/10.1...
Key findings 🧵👇
www.biorxiv.org/content/10.1...
Key findings 🧵👇
Negative design enables cell-free expression and folding of designed transmembrane β-Barrels
De novo design of membrane proteins (MPs) is a rapidly growing field with transformative potential for synthetic biology. Yet, progress has lagged behind that of soluble proteins, largely due to limit...
www.biorxiv.org
September 22, 2025 at 9:00 PM
Very proud to share the first-author work from my first PhD student, Giacomo Pedrelli 🎉. He combined cell-free expression and computational design to explore how transmembrane β-barrels fold – and what that means for designing them from scratch.
www.biorxiv.org/content/10.1...
Key findings 🧵👇
www.biorxiv.org/content/10.1...
Key findings 🧵👇