Autoimmune🦋
@autoimmuneaware.bsky.social
Reposted by Autoimmune🦋
Mechanisms of prothrombotic cell activation by anti-β2GPI IgG. The diagram highlights the receptors most commonly linked to cell activation by β2GPI/anti-β2GPI IgG surface complexes, as well as some effectors known to be downstream of that activation
#Rheumsky #Immunosky
#Rheumsky #Immunosky
May 26, 2025 at 12:55 PM
Mechanisms of prothrombotic cell activation by anti-β2GPI IgG. The diagram highlights the receptors most commonly linked to cell activation by β2GPI/anti-β2GPI IgG surface complexes, as well as some effectors known to be downstream of that activation
#Rheumsky #Immunosky
#Rheumsky #Immunosky
Non-Criteria Obstetric Antiphospholipid Syndrome: Myth or Reality?
NC-OAPS: heterogeneous condition and ambiguously described in literature
#APS #OAPS #Pregnancy #autoimmune
NC-OAPS: heterogeneous condition and ambiguously described in literature
#APS #OAPS #Pregnancy #autoimmune
mdpi-res.com
May 17, 2025 at 4:21 PM
Non-Criteria Obstetric Antiphospholipid Syndrome: Myth or Reality?
NC-OAPS: heterogeneous condition and ambiguously described in literature
#APS #OAPS #Pregnancy #autoimmune
NC-OAPS: heterogeneous condition and ambiguously described in literature
#APS #OAPS #Pregnancy #autoimmune
Reposted by Autoimmune🦋
Today is International Vasculitis Day!
Take a look at some of our articles on vasculitis:
Evidence-Based Guideline for the diagnosis and management of eosinophilic granulomatosis with polyangiitis bit.ly/4kjASRj
The new look of classification criteria for systemic vasculitis bit.ly/3GXJLlc
Take a look at some of our articles on vasculitis:
Evidence-Based Guideline for the diagnosis and management of eosinophilic granulomatosis with polyangiitis bit.ly/4kjASRj
The new look of classification criteria for systemic vasculitis bit.ly/3GXJLlc
Evidence-Based Guideline for the diagnosis and management of eosinophilic granulomatosis with polyangiitis - Nature Reviews Rheumatology
This article presents the first Evidence-Based Guideline dedicated specifically to the diagnosis and management of eosinophilic granulomatosis with polyangiitis. The 16 statements and five overarching...
bit.ly
May 15, 2025 at 4:15 PM
Today is International Vasculitis Day!
Take a look at some of our articles on vasculitis:
Evidence-Based Guideline for the diagnosis and management of eosinophilic granulomatosis with polyangiitis bit.ly/4kjASRj
The new look of classification criteria for systemic vasculitis bit.ly/3GXJLlc
Take a look at some of our articles on vasculitis:
Evidence-Based Guideline for the diagnosis and management of eosinophilic granulomatosis with polyangiitis bit.ly/4kjASRj
The new look of classification criteria for systemic vasculitis bit.ly/3GXJLlc
Behçet syndrome
🩸systemic #vasculitis, affects vessels of all calibers
🩺 venous #thrombosis with arterial #aneurysms, inflammatory parenchymal brain involvement, posterior #uveitis with retinal vasculitis, bipolar #ulcers and erythema nodosum
⁉️ controversy: pathergy test or HLA-B*51 in diagnosis
🩸systemic #vasculitis, affects vessels of all calibers
🩺 venous #thrombosis with arterial #aneurysms, inflammatory parenchymal brain involvement, posterior #uveitis with retinal vasculitis, bipolar #ulcers and erythema nodosum
⁉️ controversy: pathergy test or HLA-B*51 in diagnosis
www.sciencedirect.com
May 15, 2025 at 6:26 PM
Behçet syndrome
🩸systemic #vasculitis, affects vessels of all calibers
🩺 venous #thrombosis with arterial #aneurysms, inflammatory parenchymal brain involvement, posterior #uveitis with retinal vasculitis, bipolar #ulcers and erythema nodosum
⁉️ controversy: pathergy test or HLA-B*51 in diagnosis
🩸systemic #vasculitis, affects vessels of all calibers
🩺 venous #thrombosis with arterial #aneurysms, inflammatory parenchymal brain involvement, posterior #uveitis with retinal vasculitis, bipolar #ulcers and erythema nodosum
⁉️ controversy: pathergy test or HLA-B*51 in diagnosis
Arterial and venous thrombosis in systemic and monogenic vasculitis
⚠️ Be aware for early diagnosis‼️
🧬 Genetic testing vital—variable penetrance! Early strokes hint at diagnosis.
#vasculitis #thrombosis #monogenic #stroke #skin
www.nature.com/articles/s41...
⚠️ Be aware for early diagnosis‼️
🧬 Genetic testing vital—variable penetrance! Early strokes hint at diagnosis.
#vasculitis #thrombosis #monogenic #stroke #skin
www.nature.com/articles/s41...
Arterial and venous thrombosis in systemic and monogenic vasculitis - Nature Reviews Rheumatology
Systemic vasculitis, including monogenic forms, is associated with an increased risk of arterial and venous thromboembolic events (AVTEs). This Review highlights the latest advances in the understandi...
www.nature.com
May 14, 2025 at 7:49 PM
Arterial and venous thrombosis in systemic and monogenic vasculitis
⚠️ Be aware for early diagnosis‼️
🧬 Genetic testing vital—variable penetrance! Early strokes hint at diagnosis.
#vasculitis #thrombosis #monogenic #stroke #skin
www.nature.com/articles/s41...
⚠️ Be aware for early diagnosis‼️
🧬 Genetic testing vital—variable penetrance! Early strokes hint at diagnosis.
#vasculitis #thrombosis #monogenic #stroke #skin
www.nature.com/articles/s41...
🚨2024 American College of Rheumatology (ACR)
Guideline for the Screening, Treatment, and
Management of Lupus Nephritis
#Lupus #Nephritis #Guideline #Treatment #SLE
assets.contentstack.io/v3/assets/bl...
Guideline for the Screening, Treatment, and
Management of Lupus Nephritis
#Lupus #Nephritis #Guideline #Treatment #SLE
assets.contentstack.io/v3/assets/bl...
assets.contentstack.io
May 9, 2025 at 10:00 AM
🚨2024 American College of Rheumatology (ACR)
Guideline for the Screening, Treatment, and
Management of Lupus Nephritis
#Lupus #Nephritis #Guideline #Treatment #SLE
assets.contentstack.io/v3/assets/bl...
Guideline for the Screening, Treatment, and
Management of Lupus Nephritis
#Lupus #Nephritis #Guideline #Treatment #SLE
assets.contentstack.io/v3/assets/bl...
Consensus nomenclature and abbreviation for anti-synthetase syndrome: an IMACS project
🚩lack of uniform terminology and abbreviations = challenges in research and clinical practice
🏳️anti-synthetase syndrome and ASyS should be adopted as the standard nomenclature
academic.oup.com/rheumatology...
🚩lack of uniform terminology and abbreviations = challenges in research and clinical practice
🏳️anti-synthetase syndrome and ASyS should be adopted as the standard nomenclature
academic.oup.com/rheumatology...
Consensus nomenclature and abbreviation for anti-synthetase syndrome: an IMACS project
ABSTRACTObjectives. The lack of uniform terminology and abbreviations for anti-synthetase syndrome has led to significant challenges in research and clinic
academic.oup.com
May 4, 2025 at 10:05 AM
Consensus nomenclature and abbreviation for anti-synthetase syndrome: an IMACS project
🚩lack of uniform terminology and abbreviations = challenges in research and clinical practice
🏳️anti-synthetase syndrome and ASyS should be adopted as the standard nomenclature
academic.oup.com/rheumatology...
🚩lack of uniform terminology and abbreviations = challenges in research and clinical practice
🏳️anti-synthetase syndrome and ASyS should be adopted as the standard nomenclature
academic.oup.com/rheumatology...
Remnant cholesterol predicts risk
of recurrent thrombosis beyond LDL‑cholesterol
in patients with antiphospholipid syndrome
🟠RC ➡️ increased risk of trombosis
🟠RC marker for thrombotic risk❓
🟠potential target
for therapeutic intervention.
bmcmedicine.biomedcentral.com/counter/pdf/...
of recurrent thrombosis beyond LDL‑cholesterol
in patients with antiphospholipid syndrome
🟠RC ➡️ increased risk of trombosis
🟠RC marker for thrombotic risk❓
🟠potential target
for therapeutic intervention.
bmcmedicine.biomedcentral.com/counter/pdf/...
bmcmedicine.biomedcentral.com
April 29, 2025 at 8:03 PM
Remnant cholesterol predicts risk
of recurrent thrombosis beyond LDL‑cholesterol
in patients with antiphospholipid syndrome
🟠RC ➡️ increased risk of trombosis
🟠RC marker for thrombotic risk❓
🟠potential target
for therapeutic intervention.
bmcmedicine.biomedcentral.com/counter/pdf/...
of recurrent thrombosis beyond LDL‑cholesterol
in patients with antiphospholipid syndrome
🟠RC ➡️ increased risk of trombosis
🟠RC marker for thrombotic risk❓
🟠potential target
for therapeutic intervention.
bmcmedicine.biomedcentral.com/counter/pdf/...
EULAR recommendations for use of antirheumatic
drugs in reproduction, pregnancy, and lactation: 2024
update
🤰🏽👩🏽🍼
ard.eular.org/action/showP...
drugs in reproduction, pregnancy, and lactation: 2024
update
🤰🏽👩🏽🍼
ard.eular.org/action/showP...
ard.eular.org
April 29, 2025 at 6:42 PM
EULAR recommendations for use of antirheumatic
drugs in reproduction, pregnancy, and lactation: 2024
update
🤰🏽👩🏽🍼
ard.eular.org/action/showP...
drugs in reproduction, pregnancy, and lactation: 2024
update
🤰🏽👩🏽🍼
ard.eular.org/action/showP...
Recommendations for the use of DMARDs in pregnancy and reproductive health for patients with rheumatic disease: A scoping review
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
Recommendations for the use of DMARDs in pregnancy and reproductive health for patients with rheumatic disease: A scoping review
Objective Autoimmune rheumatic diseases commonly affect individuals of childbearing age, with historically increased adverse pregnancy outcomes in this group. The advent of disease-modifying anti-rh...
acrjournals.onlinelibrary.wiley.com
April 25, 2025 at 5:24 AM
Recommendations for the use of DMARDs in pregnancy and reproductive health for patients with rheumatic disease: A scoping review
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
IL-10 in Systemic Lupus Erythematosus: Balancing Immunoregulation and Autoimmunity
🔑involved in inflammatory and immune processes in SLE.
🔹IL-10 did not correlate with disease activity, organ in-
volvement, or treatment response.
www.mdpi.com/1422-0067/26...
🔑involved in inflammatory and immune processes in SLE.
🔹IL-10 did not correlate with disease activity, organ in-
volvement, or treatment response.
www.mdpi.com/1422-0067/26...
www.mdpi.com
April 20, 2025 at 6:17 PM
IL-10 in Systemic Lupus Erythematosus: Balancing Immunoregulation and Autoimmunity
🔑involved in inflammatory and immune processes in SLE.
🔹IL-10 did not correlate with disease activity, organ in-
volvement, or treatment response.
www.mdpi.com/1422-0067/26...
🔑involved in inflammatory and immune processes in SLE.
🔹IL-10 did not correlate with disease activity, organ in-
volvement, or treatment response.
www.mdpi.com/1422-0067/26...
A proposed clinical tool to identify high-risk patients for #monogenic #lupus: a pilot study
💡<5 years
💡cosanguinity
💡Family #SLE
💡elevated ANA
💡pancytopenia
💡cutaneus lesions
💡Low C1q
💡Recurrent infections
💡Failure to thrive
www.clinexprheumatol.org/abstract.asp...
💡<5 years
💡cosanguinity
💡Family #SLE
💡elevated ANA
💡pancytopenia
💡cutaneus lesions
💡Low C1q
💡Recurrent infections
💡Failure to thrive
www.clinexprheumatol.org/abstract.asp...
A proposed clinical tool to identify high-risk patients for monogenic lupus: a pilot study
Paediatric Rheumatology; Authors: S.M. Al-Mayouf, D. Hadef, N. Aljaberi, N. Movahedi, A. Aleed, A. Almutairi, A. Asiri, S. Volpi, M. Gattorno, C.-Y. Wu, H. Tamim, A. Al-Saleem
www.clinexprheumatol.org
April 20, 2025 at 9:44 AM
A proposed clinical tool to identify high-risk patients for #monogenic #lupus: a pilot study
💡<5 years
💡cosanguinity
💡Family #SLE
💡elevated ANA
💡pancytopenia
💡cutaneus lesions
💡Low C1q
💡Recurrent infections
💡Failure to thrive
www.clinexprheumatol.org/abstract.asp...
💡<5 years
💡cosanguinity
💡Family #SLE
💡elevated ANA
💡pancytopenia
💡cutaneus lesions
💡Low C1q
💡Recurrent infections
💡Failure to thrive
www.clinexprheumatol.org/abstract.asp...
Therapeutic approaches for
#SAPHO syndrome from the
perspective of pathogenesis:
a review of the literature
🔸Autoinflammatory
🔸cutaneous & osteoarticular
🔹ATB, tonsillectomy
🔹DMARDs
🔹Bisphosphonates
www.frontiersin.org/journals/imm...
#SAPHO syndrome from the
perspective of pathogenesis:
a review of the literature
🔸Autoinflammatory
🔸cutaneous & osteoarticular
🔹ATB, tonsillectomy
🔹DMARDs
🔹Bisphosphonates
www.frontiersin.org/journals/imm...
www.frontiersin.org
April 16, 2025 at 1:20 PM
Therapeutic approaches for
#SAPHO syndrome from the
perspective of pathogenesis:
a review of the literature
🔸Autoinflammatory
🔸cutaneous & osteoarticular
🔹ATB, tonsillectomy
🔹DMARDs
🔹Bisphosphonates
www.frontiersin.org/journals/imm...
#SAPHO syndrome from the
perspective of pathogenesis:
a review of the literature
🔸Autoinflammatory
🔸cutaneous & osteoarticular
🔹ATB, tonsillectomy
🔹DMARDs
🔹Bisphosphonates
www.frontiersin.org/journals/imm...
British Association of Dermatologists and British Society for Rheumatology living guideline for managing people with Behçets 2024
👇🏼👀
academic.oup.com/bjd/article/...
👇🏼👀
academic.oup.com/bjd/article/...
British Association of Dermatologists and British Society for Rheumatology living guideline for managing people with Behçets 2024
The overall objective of the guideline is to provide up-to-date, evidence-based recommendations for the management of Behçets. The document aims to offer a
academic.oup.com
April 16, 2025 at 11:49 AM
British Association of Dermatologists and British Society for Rheumatology living guideline for managing people with Behçets 2024
👇🏼👀
academic.oup.com/bjd/article/...
👇🏼👀
academic.oup.com/bjd/article/...
Prognostic insights from symptom clustering analysis in systemic lupus erythematosus
1️⃣ Articular/mucocutaneous ➡️better survival
2️⃣Severe phenotype with renal involvement ➡️ poor prognosis
3️⃣Mixed connective tissue disease-like features with anti-U1-RNP antibodies
rmdopen.bmj.com/content/11/2...
1️⃣ Articular/mucocutaneous ➡️better survival
2️⃣Severe phenotype with renal involvement ➡️ poor prognosis
3️⃣Mixed connective tissue disease-like features with anti-U1-RNP antibodies
rmdopen.bmj.com/content/11/2...
Prognostic insights from symptom clustering analysis in systemic lupus erythematosus
Objective Systemic lupus erythematosus (SLE), a systemic autoimmune disease with heterogeneous severity, poses a challenge in classifying patients due to its dynamic phenotype. We therefore aimed to i...
rmdopen.bmj.com
April 16, 2025 at 8:38 AM
Prognostic insights from symptom clustering analysis in systemic lupus erythematosus
1️⃣ Articular/mucocutaneous ➡️better survival
2️⃣Severe phenotype with renal involvement ➡️ poor prognosis
3️⃣Mixed connective tissue disease-like features with anti-U1-RNP antibodies
rmdopen.bmj.com/content/11/2...
1️⃣ Articular/mucocutaneous ➡️better survival
2️⃣Severe phenotype with renal involvement ➡️ poor prognosis
3️⃣Mixed connective tissue disease-like features with anti-U1-RNP antibodies
rmdopen.bmj.com/content/11/2...
Urine Protein Tests in Systemic Lupus Erythematosus:
What Do They Mean?
#SLE #Lupus #LN
www.jrheum.org/content/jrhe...
What Do They Mean?
#SLE #Lupus #LN
www.jrheum.org/content/jrhe...
www.jrheum.org
April 9, 2025 at 12:20 PM
Urine Protein Tests in Systemic Lupus Erythematosus:
What Do They Mean?
#SLE #Lupus #LN
www.jrheum.org/content/jrhe...
What Do They Mean?
#SLE #Lupus #LN
www.jrheum.org/content/jrhe...
Antiphospholipid syndrome in pregnancy: a comprehensive literature review
🤍
bmcpregnancychildbirth.biomedcentral.com/articles/10....
🤍
bmcpregnancychildbirth.biomedcentral.com/articles/10....
Antiphospholipid syndrome in pregnancy: a comprehensive literature review - BMC Pregnancy and Childbirth
Background Antiphospholipid syndrome (APS) is an autoimmune disorder associated with thrombotic events and adverse obstetric outcomes, particularly in its obstetric form (OAPS). Affecting approximatel...
bmcpregnancychildbirth.biomedcentral.com
April 5, 2025 at 2:45 PM
Antiphospholipid syndrome in pregnancy: a comprehensive literature review
🤍
bmcpregnancychildbirth.biomedcentral.com/articles/10....
🤍
bmcpregnancychildbirth.biomedcentral.com/articles/10....
A Phase 3 Trial of Upadacitinib for Giant-Cell Arteritis
📌In patients with giant-cell arteritis, upadacitinib at a dose of 15 mg — but not 7.5 mg — with a 26-week glucocorticoid taper showed efficacy superior to that of placebo with a 52-week glucocorticoid taper
www.nejm.org/doi/full/10....
📌In patients with giant-cell arteritis, upadacitinib at a dose of 15 mg — but not 7.5 mg — with a 26-week glucocorticoid taper showed efficacy superior to that of placebo with a 52-week glucocorticoid taper
www.nejm.org/doi/full/10....
A Phase 3 Trial of Upadacitinib for Giant-Cell Arteritis | NEJM
Giant-cell arteritis is a systemic vasculitis with limited treatment options. The
efficacy and safety of upadacitinib — a selective Janus kinase (JAK) inhibitor that
blocks the signaling of several...
www.nejm.org
April 3, 2025 at 8:17 PM
A Phase 3 Trial of Upadacitinib for Giant-Cell Arteritis
📌In patients with giant-cell arteritis, upadacitinib at a dose of 15 mg — but not 7.5 mg — with a 26-week glucocorticoid taper showed efficacy superior to that of placebo with a 52-week glucocorticoid taper
www.nejm.org/doi/full/10....
📌In patients with giant-cell arteritis, upadacitinib at a dose of 15 mg — but not 7.5 mg — with a 26-week glucocorticoid taper showed efficacy superior to that of placebo with a 52-week glucocorticoid taper
www.nejm.org/doi/full/10....
Comparative Efficacy of Immunosuppressive Therapies in the Treatment of Diffuse Cutaneous Systemic Sclerosis
🔸MMF in dcSSc and show benefit especially in early-stage disease. 🔸High-risk ab for lung fibrosis ➡️ suitable for MMF treatment.
acrjournals.onlinelibrary.wiley.com/doi/full/10....
🔸MMF in dcSSc and show benefit especially in early-stage disease. 🔸High-risk ab for lung fibrosis ➡️ suitable for MMF treatment.
acrjournals.onlinelibrary.wiley.com/doi/full/10....
Comparative Efficacy of Immunosuppressive Therapies in the Treatment of Diffuse Cutaneous Systemic Sclerosis
Objectives The RESOLVE-1 trial of lenabasum in diffuse cutaneous systemic sclerosis (dcSSc) allowed background immunosuppressive therapy (IST) at the discretion of individual investigators, and no s...
acrjournals.onlinelibrary.wiley.com
March 31, 2025 at 12:23 PM
Comparative Efficacy of Immunosuppressive Therapies in the Treatment of Diffuse Cutaneous Systemic Sclerosis
🔸MMF in dcSSc and show benefit especially in early-stage disease. 🔸High-risk ab for lung fibrosis ➡️ suitable for MMF treatment.
acrjournals.onlinelibrary.wiley.com/doi/full/10....
🔸MMF in dcSSc and show benefit especially in early-stage disease. 🔸High-risk ab for lung fibrosis ➡️ suitable for MMF treatment.
acrjournals.onlinelibrary.wiley.com/doi/full/10....
Thoracic Manifestations of ANCA-associated Vasculitis: Review of the 2022 American College of Rheumatology–European Alliance of Associations of Rheumatology Classification Criteria
#ANCA #Vasculitis
pubs.rsna.org/doi/10.1148/...
#ANCA #Vasculitis
pubs.rsna.org/doi/10.1148/...
Thoracic Manifestations of ANCA-associated Vasculitis: Review of the 2022 American College of Rheumatology–European Alliance of Associations of Rheumatology Cla...
The American College of Rheumatology–European Alliance of Associations of Rheumatology classification criteria were released in 2022 to increase the likelihood of antineutrophil cytoplasmic autoant...
pubs.rsna.org
March 28, 2025 at 7:51 PM
Thoracic Manifestations of ANCA-associated Vasculitis: Review of the 2022 American College of Rheumatology–European Alliance of Associations of Rheumatology Classification Criteria
#ANCA #Vasculitis
pubs.rsna.org/doi/10.1148/...
#ANCA #Vasculitis
pubs.rsna.org/doi/10.1148/...
2024 American College of Rheumatology (ACR) Guideline for the Screening, Treatment, and Management of Lupus Nephritis
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
2024 American College of Rheumatology (ACR) Guideline for the Screening, Treatment, and Management of Lupus Nephritis
The accepted version of this article was posted prematurely on March 24, 2025. The final version of record will be made fully available at a later date.
acrjournals.onlinelibrary.wiley.com
March 28, 2025 at 7:07 AM
2024 American College of Rheumatology (ACR) Guideline for the Screening, Treatment, and Management of Lupus Nephritis
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...