Alexander Minges
@athemis.bsky.athemis.de
Former structural biologist turned data steward. Cyclist and cat owner/servant.
Mastodon: @athemis@nrw.social
Mastodon: @athemis@nrw.social
Presenting #RDM in @crc1430.bsky.social at #TdF2025 @unidue.bsky.social and @ubdue.bsky.social
Poster available: doi.org/10.17185/due...
Poster available: doi.org/10.17185/due...
November 18, 2025 at 11:13 AM
Presenting #RDM in @crc1430.bsky.social at #TdF2025 @unidue.bsky.social and @ubdue.bsky.social
Poster available: doi.org/10.17185/due...
Poster available: doi.org/10.17185/due...
Reposted by Alexander Minges
Super happy to share that our work on the specific inhibition of USP30 - a clinical stage Parkinson's drug target - is now online at NSMB www.nature.com/articles/s41... Have a read if you fancy chimeric protein engineering or a framework for DUB ligandability. Huge congratulations to Nafizul & team!
Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30 - Nature Structural & Molecular Biology
Kazi et al. report the crystal structure of the mitochondrial deubiquitinase USP, a clinical stage Parkinson’s disease drug target, in complex with a specific inhibitor. The authors delineate a framew...
www.nature.com
May 5, 2025 at 11:02 AM
Super happy to share that our work on the specific inhibition of USP30 - a clinical stage Parkinson's drug target - is now online at NSMB www.nature.com/articles/s41... Have a read if you fancy chimeric protein engineering or a framework for DUB ligandability. Huge congratulations to Nafizul & team!
Grateful for the fantastic #Dataverse upload event of the @crc1430.bsky.social. Many inspiring discussions and a huge pile of datasets for me to work through the next days. Thanks to all participants!
March 18, 2025 at 5:54 PM
Grateful for the fantastic #Dataverse upload event of the @crc1430.bsky.social. Many inspiring discussions and a huge pile of datasets for me to work through the next days. Thanks to all participants!
Reposted by Alexander Minges
🚀 We’re proud to celebrate Gina Simon, a @crc1430.bsky.social PhD researcher in @hellerschmiedlab.bsky.social at @unidue-zmb.bsky.social, who received the Data Champion Award! Gina shares how eLabFTW streamlines research and boosts efficiency.
#DataChampion #eLabFTW
www.uni-due.de/rds/en/datac...
#DataChampion #eLabFTW
www.uni-due.de/rds/en/datac...
Data Champion: Gina Simon
www.uni-due.de
March 10, 2025 at 9:51 AM
🚀 We’re proud to celebrate Gina Simon, a @crc1430.bsky.social PhD researcher in @hellerschmiedlab.bsky.social at @unidue-zmb.bsky.social, who received the Data Champion Award! Gina shares how eLabFTW streamlines research and boosts efficiency.
#DataChampion #eLabFTW
www.uni-due.de/rds/en/datac...
#DataChampion #eLabFTW
www.uni-due.de/rds/en/datac...
Reposted by Alexander Minges
Tomatoes lose their bitterness and toxicity as they ripen thanks to DNA demethylation, the hormone ethylene, and key transcription factors, finds a new #ScienceAdvances study. scim.ag/4bfdr8u
Removal of toxic steroidal glycoalkaloids and bitterness in tomato is controlled by a complex epigenetic and genetic network
A complex regulatory network controls the removal of toxic steroidal glycoalkaloids during tomato ripening.
scim.ag
February 25, 2025 at 2:25 PM
Tomatoes lose their bitterness and toxicity as they ripen thanks to DNA demethylation, the hormone ethylene, and key transcription factors, finds a new #ScienceAdvances study. scim.ag/4bfdr8u
Reposted by Alexander Minges
Many crystal structure analyses that previously required experimental phase evaluation can now be solved by AlphaFold-guided MR. In effect, this and related MR approaches are de novo phasing methods. #MolecularReplacement #MachineLearning doi.org/10.1107/S205...
February 24, 2025 at 2:55 PM
Many crystal structure analyses that previously required experimental phase evaluation can now be solved by AlphaFold-guided MR. In effect, this and related MR approaches are de novo phasing methods. #MolecularReplacement #MachineLearning doi.org/10.1107/S205...
Reposted by Alexander Minges
Interested in developing a dataset for a Large Language Models (LLMs) project?
Register for March 5:
www.ebi.ac.uk/training/eve...
Webinar by Melanie Vollmar
(ARISE Fellow working with @pdbeurope.bsky.social team)
From @training.ebi.embl.org's series on:
LLM & Bioinformatics
Register for March 5:
www.ebi.ac.uk/training/eve...
Webinar by Melanie Vollmar
(ARISE Fellow working with @pdbeurope.bsky.social team)
From @training.ebi.embl.org's series on:
LLM & Bioinformatics
Developing a dataset for LLM projects -
Developing a dataset for LLM projects -
www.ebi.ac.uk
February 17, 2025 at 1:53 PM
Interested in developing a dataset for a Large Language Models (LLMs) project?
Register for March 5:
www.ebi.ac.uk/training/eve...
Webinar by Melanie Vollmar
(ARISE Fellow working with @pdbeurope.bsky.social team)
From @training.ebi.embl.org's series on:
LLM & Bioinformatics
Register for March 5:
www.ebi.ac.uk/training/eve...
Webinar by Melanie Vollmar
(ARISE Fellow working with @pdbeurope.bsky.social team)
From @training.ebi.embl.org's series on:
LLM & Bioinformatics
Reposted by Alexander Minges
🚀 Die Gesundheitsberichterstattung #GBE am #RKI stellt regelmäßig Daten zu nichtübertragbaren Krankheiten und ihren Einflussfaktoren auf #GitHub und #Zenodo bereit: maschinenlesbar, offen, frei verwendbar.
🔗 www.gbe.rki.de/DE/Startseit...
#OpenData #Gesundheit #Transparenz #PublicHealth
🔗 www.gbe.rki.de/DE/Startseit...
#OpenData #Gesundheit #Transparenz #PublicHealth
February 12, 2025 at 4:42 PM
🚀 Die Gesundheitsberichterstattung #GBE am #RKI stellt regelmäßig Daten zu nichtübertragbaren Krankheiten und ihren Einflussfaktoren auf #GitHub und #Zenodo bereit: maschinenlesbar, offen, frei verwendbar.
🔗 www.gbe.rki.de/DE/Startseit...
#OpenData #Gesundheit #Transparenz #PublicHealth
🔗 www.gbe.rki.de/DE/Startseit...
#OpenData #Gesundheit #Transparenz #PublicHealth
Reposted by Alexander Minges
Reposted by Alexander Minges
Just because it's a homo-oligomer, don't assume it's symmetric! @benjabsnt.bsky.social & collaborators used cryo-EM to study the transthyretin (TTR) tetramer (55 kDa), shedding light on its misfolding pathways linked to amyloid disease. Now in peer-reviewed form: www.nature.com/articles/s41...
January 22, 2025 at 4:45 PM
Just because it's a homo-oligomer, don't assume it's symmetric! @benjabsnt.bsky.social & collaborators used cryo-EM to study the transthyretin (TTR) tetramer (55 kDa), shedding light on its misfolding pathways linked to amyloid disease. Now in peer-reviewed form: www.nature.com/articles/s41...
Reposted by Alexander Minges
In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:
January 17, 2025 at 6:43 PM
In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:
Reposted by Alexander Minges
PDB-IHM (formerly PDB-Dev) is for integrative structures.
Intergrative structures = from multiple experimental & computational methods.
Since mid-2024 assigned PDB ids & DOIs.
Access via wwPDB archive or
PDB-IHM - pdb-ihm.org
👉 https://www.wwpdb.org/news/news?year=2025#677880ea44a8c95814022eb9
Intergrative structures = from multiple experimental & computational methods.
Since mid-2024 assigned PDB ids & DOIs.
Access via wwPDB archive or
PDB-IHM - pdb-ihm.org
👉 https://www.wwpdb.org/news/news?year=2025#677880ea44a8c95814022eb9
January 17, 2025 at 1:35 PM
PDB-IHM (formerly PDB-Dev) is for integrative structures.
Intergrative structures = from multiple experimental & computational methods.
Since mid-2024 assigned PDB ids & DOIs.
Access via wwPDB archive or
PDB-IHM - pdb-ihm.org
👉 https://www.wwpdb.org/news/news?year=2025#677880ea44a8c95814022eb9
Intergrative structures = from multiple experimental & computational methods.
Since mid-2024 assigned PDB ids & DOIs.
Access via wwPDB archive or
PDB-IHM - pdb-ihm.org
👉 https://www.wwpdb.org/news/news?year=2025#677880ea44a8c95814022eb9
Reposted by Alexander Minges
This is just out and already looks like textbook material
#MustRead
#MustRead
How do proteins mis-fold?
Paper led by Jacob Aunstrup from Alex Büll’s lab with MD simulations by Abigail Barclay, and key contributions from several others. We combined measurements of Φ-values with MD simulations to study the transition state for amyloid fibril growth
doi.org/10.1038/s415...
Paper led by Jacob Aunstrup from Alex Büll’s lab with MD simulations by Abigail Barclay, and key contributions from several others. We combined measurements of Φ-values with MD simulations to study the transition state for amyloid fibril growth
doi.org/10.1038/s415...
January 16, 2025 at 3:38 PM
This is just out and already looks like textbook material
#MustRead
#MustRead