Astri Kusumawardhani
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astrikusuma.bsky.social
Astri Kusumawardhani
@astrikusuma.bsky.social
Mom of 2, Loves tinkering with bacteria! 🧬🧫
Postdoc at the Schaerli lab, UNIL🇨🇭
Reposted by Astri Kusumawardhani
NEW paper 🚨! We engineered TNT sensors in soil bacteria for long-term detection of explosive in natural soil, enabling geospatial detection of contaminated soil. This work (led by Erin Essington) included new sensors, circuits, modeling, & a 28-day testing workflow. 1/
www.nature.com/articles/s41...
An autonomous microbial sensor enables long-term detection of TNT explosive in natural soil - Nature Communications
Engineered microbes can detect harmful chemicals, but may not work well in complex environments. Here, the authors built microbial sensors for detection of TNT explosive and tested their response over...
www.nature.com
December 2, 2024 at 1:00 PM
Reposted by Astri Kusumawardhani
Reposted by Astri Kusumawardhani
Genetic encoding and expression of RNA origami cytoskeletons in synthetic cells https://www.biorxiv.org/content/10.1101/2024.06.12.598448v1
Genetic encoding and expression of RNA origami cytoskeletons in synthetic cells https://www.biorxiv.org/content/10.1101/2024.06.12.598448v1
The central dogma at the core of molecular biology states that information flows from DNA to RNA and
www.biorxiv.org
June 13, 2024 at 5:05 AM
Reposted by Astri Kusumawardhani
PyCoMo: a python package for community metabolic model creation and analysis academic.oup.com/bioinformati... #jcampubs
PyCoMo: a python package for community metabolic model creation and analysis
AbstractSummary. PyCoMo is a python package for quick and easy generation of genome-scale compartmentalized community metabolic models that are compliant w
academic.oup.com
April 12, 2024 at 1:16 PM
Reposted by Astri Kusumawardhani
Very happy to share our latest preprint DMF UNIL: Jung and Gábor controlled the ring patterns in E. coli colonies generated by a synthetic oscillator with optogenetics. We observed synchronisation, resonance, entrainment, undertone, period doubling and even chaos! Feedback welcome.
April 2, 2024 at 10:18 AM
Reposted by Astri Kusumawardhani
www.advancedsciencenews.com/a-living-bio...

Nice news article in “Advanced Science News” covering our recent publication (result of a collaboration with @pengellab.bsky.social as part of the NCCR Microbiomes).
A living biosensor helps track honeybee health - Advanced Science News
First living biosensor developed to study honeybee gut microbiome, providing insights into health and conservation.
www.advancedsciencenews.com
March 26, 2024 at 5:55 AM
Reposted by Astri Kusumawardhani
Filamentous Phage Shields
by Roberto — Elaborate mechanisms that protect bacteria against phage are well known, with CRISPR leading the way. Less familiar but equally fascinating is the fact that, somewhat unexpectedly, phages themselves sometimes offer...
Read more > tinyurl.com/yktjj3z7
#MicroSky
March 21, 2024 at 8:58 AM
Reposted by Astri Kusumawardhani
Bottlenecks in the Implementation of Genome Scale Metabolic Model Based Designs for Bioproduction from Aromatic Carbon Sources https://www.biorxiv.org/content/10.1101/2024.03.15.585139v1
Bottlenecks in the Implementation of Genome Scale Metabolic Model Based Designs for Bioproduction from Aromatic Carbon Sources https://www.biorxiv.org/content/10.1101/2024.03.15.585139v1
Genome scale metabolic models (GSMM) are commonly used to identify gene deletion sets that result in
www.biorxiv.org
March 17, 2024 at 5:16 AM
Reposted by Astri Kusumawardhani
Amazing to see this finally out!!From competition to collaboration: we show how 2 bacterial species that compete for a carbon source can interact positively in a toxic environment, with one species removing ROS to the benefit of the other plos.io/3SOvRnZ congrats Aurore Picot & Rita Di Martino
February 6, 2024 at 2:44 PM
Reposted by Astri Kusumawardhani
Our paper engineering yeast to be phototrophic (gaining energy from light) by chucking a rhodopsin into the vacuole is out in Current Biology. www.cell.com/current-biol...
January 25, 2024 at 9:45 PM
Reposted by Astri Kusumawardhani
How stable are bacterial genomes as they adapt to an environment? My collaboration with
Anurag Limdi, Alex Couce, @relenski.bsky.social, and
Olivier Tenaillon exploring this over 50,000 generations of evolution is out today! 1/
(cross-post from the other place)
www.science.org/doi/10.1126/...
Changing fitness effects of mutations through long-term bacterial evolution
Predictable and parallel changes occur in the fitness effects of mutations in Escherichia coli over 50,000 generations.
www.science.org
January 26, 2024 at 8:27 PM
Reposted by Astri Kusumawardhani
why most of my scientific papers aren't really all that exciting - and why that's perfectly OK and a normal part of how science advances. With bonus architecture analogy... scientistseessquirrel.wordpress.com/2024/01/23/w...
Why most of my papers just aren’t that exciting
I’ve published about 95* papers in my career so far, and most of them aren’t very exciting. I don’t mean that they’re boring to read, as written texts. Well, most of them are boring to read, t...
scientistseessquirrel.wordpress.com
January 23, 2024 at 1:04 PM
Reposted by Astri Kusumawardhani
And its out! New paper for #integron aficionados. We found gene-less cassettes in superintegrons that express/silence other cassettes in the array. Here is a 🧵(if I know how to do this in Bluesky...😆)
academic.oup.com/nar/advance-...
Identification of promoter activity in gene-less cassettes from Vibrionaceae superintegrons
Abstract. Integrons are genetic platforms that acquire new genes encoded in integron cassettes (ICs), building arrays of adaptive functions. ICs generally encod
academic.oup.com
January 15, 2024 at 7:50 PM
Reposted by Astri Kusumawardhani
Application deadline has been extended until Feb 5th!
PhD project with me and @frimanscience.bsky.social (MSCA Horizon 2022 UTU-GreDiT). Project #11: “Understanding ecology and evolution of antimicrobial resistance in microbiomes”. Please share with potential candidates. How to apply: sites.utu.fi/utugredit/
January 17, 2024 at 12:20 PM
Reposted by Astri Kusumawardhani
Finally published! We show that host metabolites facilitate gutcolonization of a symbiont of social bees. Huge congrats to co-lead authors @andrewhq9.bsky.social & Yassine El Chazli. Super collabo with NanoSIMS expert Anders Meibom EPFL and our Electron Microscopy Facility FBM_UNIL 🐝 🧪
Host-derived organic acids enable gut colonization of the honey bee symbiont Snodgrassella alvi - Na...
Comparative metabolomics and NanoSIMs reveal that the honey bee symbiont Snodgrassella alvi uses host-derived metabolites to colonize the gut, indicating adaptation to a specific metabolic niche in it...
www.nature.com
January 15, 2024 at 10:33 PM
Reposted by Astri Kusumawardhani
#Pseudomonas enthusiasts! Join us at the international #conference Sept 1-5 · Dive into the latest research on #microbiology, clinical #infection & #biotechnology · Abstract submission opens later this week · #Pseudomonas2024 · Please spread the word!
microbiologysociety.org/event/full-e...
January 15, 2024 at 8:22 AM
Reposted by Astri Kusumawardhani
When researchers tried to evolve a yeast population to stick to plastic, they accidentally increased it’s ability to cause infection. What more can we learn about ‘accidental virulence’? elifesciences.org/articles/945...
January 10, 2024 at 1:27 PM
Reposted by Astri Kusumawardhani