Alexey Soshnev
@asoshnev.bsky.social
www.chromatin.bio
here for the ex-Twitter community
here for the ex-Twitter community
Grad school application portals that require you to make an account to submit a reference letter should not exist /rant
November 25, 2025 at 8:17 PM
Grad school application portals that require you to make an account to submit a reference letter should not exist /rant
Reposted by Alexey Soshnev
I'm guest-editing a collection on "Enhancer-promoter interactions" at Genome Biology. Please send us your exciting stories!
link.springer.com/collections/...
link.springer.com/collections/...
Enhancer-promoter interactions
Genome Biology is calling for submissions to our Collection on enhancer-promoter interactions.
Enhancer–promoter interactions are central to the regulation ...
link.springer.com
November 25, 2025 at 10:55 AM
I'm guest-editing a collection on "Enhancer-promoter interactions" at Genome Biology. Please send us your exciting stories!
link.springer.com/collections/...
link.springer.com/collections/...
Don't post often but this is a good occasion: we wrote a huge review about mechanisms that preserve chromatin fidelity, and how its progressive degradation occurs in disease. Inspired by #oncohistones but mostly *not* about that. Bonus, snuck Horace into the title!
academic.oup.com/narmolmed/ar...
academic.oup.com/narmolmed/ar...
Aere perennius: how chromatin fidelity is maintained and lost in disease
Abstract. Multicellular organisms arise from a single genome template in the zygote, necessitating the cells of the developing embryo to up- and downregula
academic.oup.com
August 13, 2025 at 2:35 PM
Don't post often but this is a good occasion: we wrote a huge review about mechanisms that preserve chromatin fidelity, and how its progressive degradation occurs in disease. Inspired by #oncohistones but mostly *not* about that. Bonus, snuck Horace into the title!
academic.oup.com/narmolmed/ar...
academic.oup.com/narmolmed/ar...
Reposted by Alexey Soshnev
Check out this 🧵 from @eimearlagan.bsky.social on our new Molecular Cell @cp-molcell.bsky.social paper! We show how the H3K27M Oncohistone reprograms chromatin in DMG, creating a specific dependency on CBX4/PCGF4-containing forms of cPRC1 👇
Excited to share our new paper out today in @cp-molcell.bsky.social! We show that the H3K27M oncohistone rewires cPRC1, creating a unique dependency on CBX4/PCGF4-containing complexes, and also reveal a previously unknown function of CBX4. Highlights below (1/11).
May 21, 2025 at 5:22 PM
Check out this 🧵 from @eimearlagan.bsky.social on our new Molecular Cell @cp-molcell.bsky.social paper! We show how the H3K27M Oncohistone reprograms chromatin in DMG, creating a specific dependency on CBX4/PCGF4-containing forms of cPRC1 👇
Reposted by Alexey Soshnev
Not that I wont be thrilled to grow a shaggy mouse...
March 4, 2025 at 6:06 PM
Not that I wont be thrilled to grow a shaggy mouse...
Reposted by Alexey Soshnev
The HuSH complex silences retrotransposable elements. We identify HuSH2, centered on TASOR2, targeting KRAB-ZNFs and interferon genes, balancing retrotransposon silencing and immune regulation. www.nature.com/articles/s41...
November 3, 2024 at 3:20 PM
The HuSH complex silences retrotransposable elements. We identify HuSH2, centered on TASOR2, targeting KRAB-ZNFs and interferon genes, balancing retrotransposon silencing and immune regulation. www.nature.com/articles/s41...