Serum antibodies from prior immune responses regulate B cell activation and germinal center (GC) access upon recall immunization. However, how antibodies produced by an ongoing immune response influen...

Regulatory T cells curb noxious sensory signaling to dampen cutaneous inflammation, a neuromodulatory mechanism for immunosuppression.

Darwinian evolution of immunoglobulin genes within germinal centers (GC) underlies the progressive increase in antibody affinity following antigen exposure. Whereas the mechanics of how competition be...

Cell-cell interactions help drive tolerogenic or inflammatory responses to the maelstrom of antigens passing through the gut.

The intestinal immune system must concomitantly tolerate food and commensals and protect against pathogens. Antigen-presenting cells (APCs) orchestrate these immune responses by presenting luminal ant...

The Parsa laboratory investigates the functional and clonal dynamics of T cells during various immune responses. Using innovative genetic approaches, we will precisely track and analyze the behavior of polyclonal perturbation-specific T cells over time and space. We seek to uncover the rules governing the development of effector and memory T cells, ultimately enhancing our understanding of adaptive immunity and advancing therapies for various diseases, including cancer and autoimmunity.

Please join us as we welcome Dr. Donaldson to UCLA in his new role as assistant professor in the Department of Microbiology, Immunology, and Molecular Genetics.