Ariana Costas
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arianacostas.bsky.social
Ariana Costas
@arianacostas.bsky.social
PhD candidate at @aimi-UTS.bsky.official and Institut Cochin, investigating the antibiotic non-response of uropathogenic E. coli during UTI🔬🧫🦠
Reposted by Ariana Costas
People spend loads on #UTI preventions that aren’t truly effective, like D-mannose. £19.99 only buys you a 2-week course. The rest of the products on display were similarly expensive and unlikely to do much. We need better therapies! (See Alt text for source of negative D-mannose RCT) #UTISky
October 2, 2025 at 7:40 AM
Reposted by Ariana Costas
Congratulations to @carlosebflores.bsky.social on his latest publication with @jennyrohn.bsky.social, "Bacterial adhesion strategies and countermeasures in urinary tract infection" in @naturemicrobiol.bsky.social

Read it here 👉 www.nature.com/articles/s41...
Bacterial adhesion strategies and countermeasures in urinary tract infection - Nature Microbiology
This Review discusses adhesion strategies of bacterial pathogens causing urinary tract infections, and outlines host responses and recent advances in therapeutic strategies targeting bacterial adhesio...
www.nature.com
March 27, 2025 at 9:22 AM
A new review for some Thursday morning reading! This paper details the elements needed to develop relevant physiologic models of the bladder and discusses current technology. Very grateful to have been a part of this review! Happy reading, everyone! #UTIsky #UTI
www.nature.com/articles/s41...
A bladder blueprint to build better models for understanding homeostasis and disease - Nature Reviews Urology
In this Review, the authors present the development, structure and microenvironment, and defence mechanisms of the bladder, which together create a blueprint that can be used to optimize current model...
www.nature.com
March 27, 2025 at 9:36 AM
Reposted by Ariana Costas
Need a break from the Christmas food? Check out the latest supercool ex-vivo UTI model from the ingersoll lab @immunobladder.bsky.social
www.biorxiv.org/content/10.1...
A simple ex vivo bladder infection model permits study of host-pathogen interactions in UTI
Urinary tract infections (UTI) are one of the most common infections, worldwide. To understand mechanisms of UTI pathogenesis and find new treatments, researchers often use animal models, such as mice...
www.biorxiv.org
December 23, 2024 at 9:40 PM
Reposted by Ariana Costas
Four out of five prizes won🎖️ by AIMI students at the UTS Faculty of Science Transdisciplinary ECR Retreat

Congratulations to:
Lachy (best talk)
Liam (runner up talk)
Sophia (people’s choice talk)
@arianacostas.bsky.social (best poster)
December 6, 2024 at 8:40 AM
Reposted by Ariana Costas
🚨 New preprint 🚨

With two excellent students Shalini Choudhary and Jacob Smith, we started looking at how the metabolic microenvironment of the urinary tract might affect uropathogenic E. coli evolution and response to antibiotics.

www.biorxiv.org/content/10.1...
Glucose alters the evolutionary response to gentamicin in uropathogenic Escherichia coli
Urinary tract infections (UTI) are a major health and economic concern. Uropathogenic Escherichia coli (UPEC) are the leading cause of UTI, and antibiotic resistant UPEC are increasingly common. The m...
www.biorxiv.org
November 27, 2024 at 8:11 AM
Reposted by Ariana Costas
🚨 New paper alert! 🚨

MinD is famously known for positioning FtsZ at mid-cell in bacteria

In our study, myself and @iduggin.bsky.social found that MinD homologues in Haloferax volcanii influence the localisation of CetZ1, a homologue of FtsZ and tubulin

#Archaeasky #Microsky
Frontiers | MinD proteins regulate CetZ1 localization in Haloferax volcanii
url.au.m.mimecastprotect.com
November 23, 2024 at 7:23 AM
Todays view from the lab 🥹❄️
November 21, 2024 at 10:07 AM
Reposted by Ariana Costas
Why is preterm birth risk doubled with maternal UTI? It depends on the immune response. We found distinct immune signatures in a UTI-associated preterm birth mouse model. In a human cohort from @AShea_Lab, urine cytokine levels could predict preterm birth. www.biorxiv.org/content/10.1...
Distinct maternofetal immune signatures delineate preterm birth onset following urinary tract infection
Preterm birth is the leading cause of infant mortality resulting in over one million neonatal deaths annually. Maternal urinary tract infection (UTI) during pregnancy increases risk for preterm birth;...
www.biorxiv.org
October 25, 2024 at 9:57 PM
Reposted by Ariana Costas
Interested in following our researchers and their work?

Find them in our starter pack of AIMI researchers!
go.bsky.app/QYFfTtT

#microsky #microbiology
November 20, 2024 at 10:55 AM
Reposted by Ariana Costas
Our mission is to decipher interlinked human, animal, and environmental problems in microbiology and disease

We investigate how microbes grow, live, adapt, and survive, with a focus on antibiotic resistance, infectious diseases, vaccine development, and biosecurity
November 20, 2024 at 10:40 AM
Reposted by Ariana Costas
JAMS Sydney has made its way to Bluesky! ✨
Help us connect JAMSters as they make their way over so let us know if you'd like to be added! 🦠

go.bsky.app/B1uUprK
November 20, 2024 at 1:54 AM
It is World Antimicrobial Resistance Awareness week and the CSIRO have some very funny memes (This ABBA one is my favourite) www.csiro.au/en/news/all/...
November 19, 2024 at 9:07 AM