Alejandro Reyes
@areyesq.bsky.social
Data Scientist at Novartis. Alumni from LCG-UNAM, DFCI and EMBL.
Our study about splicing modulating compounds is out!
Molecules like Branaplam tweak exon inclusion. We describe how RNA structure and sequence dependencies shape exon selectivity. We're even able to reprogram the specificity by co-treatment with modified U1 snRNAs.
www.biorxiv.org/content/10.1...
Molecules like Branaplam tweak exon inclusion. We describe how RNA structure and sequence dependencies shape exon selectivity. We're even able to reprogram the specificity by co-treatment with modified U1 snRNAs.
www.biorxiv.org/content/10.1...
Specificity and exon target space of splicing modifying compounds
Modulation of splicing has become an established therapeutic strategy, with proven clinical applications and continued potential to target specific exons to influence gene expression. Recent advanceme...
www.biorxiv.org
August 18, 2025 at 7:46 AM
Our study about splicing modulating compounds is out!
Molecules like Branaplam tweak exon inclusion. We describe how RNA structure and sequence dependencies shape exon selectivity. We're even able to reprogram the specificity by co-treatment with modified U1 snRNAs.
www.biorxiv.org/content/10.1...
Molecules like Branaplam tweak exon inclusion. We describe how RNA structure and sequence dependencies shape exon selectivity. We're even able to reprogram the specificity by co-treatment with modified U1 snRNAs.
www.biorxiv.org/content/10.1...
Reposted by Alejandro Reyes
I sometimes overhear conversations about tool choice in bioinformatics, where implementation language is stated as the primary criterion. Such thinking stands in the way of scientific quality and productivity. It is a form of self-harm.
What should one really care about?
(1/5)
What should one really care about?
(1/5)
June 13, 2025 at 5:23 PM
I sometimes overhear conversations about tool choice in bioinformatics, where implementation language is stated as the primary criterion. Such thinking stands in the way of scientific quality and productivity. It is a form of self-harm.
What should one really care about?
(1/5)
What should one really care about?
(1/5)
This paper is a great example of the use of multiomic/multimodal data from patient cohorts for target identification. All evidence pointing towards ZNF469 as a regulator of collagen in liver fibrosis. Lots of potential here! insight.jci.org/articles/vie...
JCI Insight -
The transcription factor ZNF469 regulates collagen production in liver fibrosis
insight.jci.org
April 11, 2025 at 11:39 AM
This paper is a great example of the use of multiomic/multimodal data from patient cohorts for target identification. All evidence pointing towards ZNF469 as a regulator of collagen in liver fibrosis. Lots of potential here! insight.jci.org/articles/vie...
Reposted by Alejandro Reyes
I just uploaded the first version of {{exactplot}} to github.com/const-ae/exa... 🎉
It produces figures with consistent font size, Latex labels, and millimeter-perfect layouting. It's an alternative to patchwork with less elegant syntax but much more flexibility.
#rstats
It produces figures with consistent font size, Latex labels, and millimeter-perfect layouting. It's an alternative to patchwork with less elegant syntax but much more flexibility.
#rstats
February 12, 2025 at 11:40 AM
I just uploaded the first version of {{exactplot}} to github.com/const-ae/exa... 🎉
It produces figures with consistent font size, Latex labels, and millimeter-perfect layouting. It's an alternative to patchwork with less elegant syntax but much more flexibility.
#rstats
It produces figures with consistent font size, Latex labels, and millimeter-perfect layouting. It's an alternative to patchwork with less elegant syntax but much more flexibility.
#rstats
Reposted by Alejandro Reyes
Do you want to learn more about the statistical analysis of proteomics, metabolomics, single-cell and spatial transcriptomics? Do you want to up your game with R and Bioconductor? All of this while enjoying summer in the beautiful Italian Alps? Join us for the 21st edition of CSAMA July 6-11!
January 27, 2025 at 8:16 AM
Do you want to learn more about the statistical analysis of proteomics, metabolomics, single-cell and spatial transcriptomics? Do you want to up your game with R and Bioconductor? All of this while enjoying summer in the beautiful Italian Alps? Join us for the 21st edition of CSAMA July 6-11!
Reposted by Alejandro Reyes
All the videos from the #cdsb2024 workshop are available now on our @cdsbmexico.bsky.social YouTube channel. If you’re interested in learning about creating R packages go take a look! All the materials are available in Spanish youtube.com/@cdsb
Community of Bioinformatics Software Developers
YouTube channel for the Community of Bioinformatics Software Developers (CDSB in Spanish)
youtube.com
January 28, 2025 at 5:21 PM
All the videos from the #cdsb2024 workshop are available now on our @cdsbmexico.bsky.social YouTube channel. If you’re interested in learning about creating R packages go take a look! All the materials are available in Spanish youtube.com/@cdsb
Reposted by Alejandro Reyes
New method for identifying spatially variable genes in spatial transcriptomics.
We use spectral graph theory to extract 1D curves related to tissue morphology, creating a more relevant coordinate system. Improves sensitivity.
with @PhillipNicol et al.
www.biorxiv.org/content/10.1...
We use spectral graph theory to extract 1D curves related to tissue morphology, creating a more relevant coordinate system. Improves sensitivity.
with @PhillipNicol et al.
www.biorxiv.org/content/10.1...
November 22, 2024 at 8:04 PM
New method for identifying spatially variable genes in spatial transcriptomics.
We use spectral graph theory to extract 1D curves related to tissue morphology, creating a more relevant coordinate system. Improves sensitivity.
with @PhillipNicol et al.
www.biorxiv.org/content/10.1...
We use spectral graph theory to extract 1D curves related to tissue morphology, creating a more relevant coordinate system. Improves sensitivity.
with @PhillipNicol et al.
www.biorxiv.org/content/10.1...
Reposted by Alejandro Reyes
Bioconductor 3.20 is released! 🎉🌟
Thanks to all developers and community members for contributing to the project! 🙌
👉 See the full release announcement: bioconductor.org/news/bioc_3_...
#Bioconductor #DataScience #Bioinformatics #OpenSource
Thanks to all developers and community members for contributing to the project! 🙌
👉 See the full release announcement: bioconductor.org/news/bioc_3_...
#Bioconductor #DataScience #Bioinformatics #OpenSource
Bioconductor - Bioconductor 3.20 Released
The Bioconductor project aims to develop and share open source software for precise and repeatable analysis of biological data. We foster an inclusive and collaborative community of developers and dat...
bioconductor.org
October 30, 2024 at 10:04 PM
Bioconductor 3.20 is released! 🎉🌟
Thanks to all developers and community members for contributing to the project! 🙌
👉 See the full release announcement: bioconductor.org/news/bioc_3_...
#Bioconductor #DataScience #Bioinformatics #OpenSource
Thanks to all developers and community members for contributing to the project! 🙌
👉 See the full release announcement: bioconductor.org/news/bioc_3_...
#Bioconductor #DataScience #Bioinformatics #OpenSource