@ara-donia.bsky.social
Reposted
Great to see this out for all to see after a lot of hard work by @lizihegarty.bsky.social and @bainlab.bsky.social. Colonic #macrophages persist but are transcriptionally altered post- #inflammation in a mouse model of #colitis.
Tissue resident colonic macrophages persist through acute inflammation and adapt to aid tissue repair https://www.biorxiv.org/content/10.1101/2025.09.19.677333v1
September 22, 2025 at 6:48 AM
Great to see this out for all to see after a lot of hard work by @lizihegarty.bsky.social and @bainlab.bsky.social. Colonic #macrophages persist but are transcriptionally altered post- #inflammation in a mouse model of #colitis.
Congratulations all!
For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Activity-driven myelin sheath growth is mediated by mGluR5 - Nature Neuroscience
Employing pharmacology, genetics and all-optical approaches in zebrafish, Braaker et al. find that neuronal activity influences the growth of myelin sheaths along axons by signaling through metabotrop...
www.nature.com
May 14, 2025 at 12:45 PM
Congratulations all!
Reposted
How does the brain repair myelin after injury?
We mapped the full cellular choreography of white matter repair using snRNA-seq + Slide-seqv2, uncovering a type I interferon-driven glial program that recruits lymphocytes to promote remyelination.
www.biorxiv.org/content/10.1...
Details below 👇
We mapped the full cellular choreography of white matter repair using snRNA-seq + Slide-seqv2, uncovering a type I interferon-driven glial program that recruits lymphocytes to promote remyelination.
www.biorxiv.org/content/10.1...
Details below 👇
Spatiotemporal Analysis of Remyelination Reveals a Concerted Interferon-Responsive Glial State That Coordinates Immune Infiltration
Remyelination, the process by which axons are re-encased in myelin after injury, is a critical step in restoring brain function, yet the dynamics from initial injury to repair remain poorly characteri...
www.biorxiv.org
April 28, 2025 at 9:09 AM
How does the brain repair myelin after injury?
We mapped the full cellular choreography of white matter repair using snRNA-seq + Slide-seqv2, uncovering a type I interferon-driven glial program that recruits lymphocytes to promote remyelination.
www.biorxiv.org/content/10.1...
Details below 👇
We mapped the full cellular choreography of white matter repair using snRNA-seq + Slide-seqv2, uncovering a type I interferon-driven glial program that recruits lymphocytes to promote remyelination.
www.biorxiv.org/content/10.1...
Details below 👇