Alexander Darlington
@apsduk.bsky.social
RAEng Research Fellow and Assistant Prof. in Control and Engineering Biology developing gene circuit design frameworks.
Reposted by Alexander Darlington
Modelling dynamic host-pathway interactions at the genome scale with machine learning
doi.org/10.1016/j.ym...
doi.org/10.1016/j.ym...
June 27, 2025 at 12:43 PM
Modelling dynamic host-pathway interactions at the genome scale with machine learning
doi.org/10.1016/j.ym...
doi.org/10.1016/j.ym...
Reposted by Alexander Darlington
When talk to colleagues, I see a growing interest in the central question of this paper: what if we’ve been designing genetic circuits the wrong way? After all, natural networks *look* very different. This work, which has gone somewhat unnoticed, is one of my favourites! doi.org/10.1162/isal...
March 26, 2025 at 6:35 PM
When talk to colleagues, I see a growing interest in the central question of this paper: what if we’ve been designing genetic circuits the wrong way? After all, natural networks *look* very different. This work, which has gone somewhat unnoticed, is one of my favourites! doi.org/10.1162/isal...
Reposted by Alexander Darlington
Pseudomonas putida joins the Olympus of effective Cell Factories www.nature.com/articles/s41... Not any longer *a promising platform* for metabolic engineering, but a phenomenal, consolidated chassis for programming degradation and synthesis of amazing molecules 😃!
Comprehensive evaluation of the capacities of microbial cell factories - Nature Communications
Constructing an efficient microbial cell factory still requires exploring and selecting various host strains, as well as identifying the best-suited metabolic engineering strategies, which demand sign...
www.nature.com
March 25, 2025 at 8:10 AM
Pseudomonas putida joins the Olympus of effective Cell Factories www.nature.com/articles/s41... Not any longer *a promising platform* for metabolic engineering, but a phenomenal, consolidated chassis for programming degradation and synthesis of amazing molecules 😃!
Great start of the year meal with the lab!
January 13, 2025 at 5:55 PM
Great start of the year meal with the lab!
Are you looking looking to engineer chemical production in batch cultures? In our recent paper with
Ahmad Mannan we show show to design genetic circuits to enhance productivity!
Link: www.nature.com/articles/s41...
Ahmad Mannan we show show to design genetic circuits to enhance productivity!
Link: www.nature.com/articles/s41...
Design principles for engineering bacteria to maximise chemical production from batch cultures - Nature Communications
Engineering microbial cell factories for chemical manufacture remains challenging due to trade-offs between production and growth. Here, the authors uncover how to design genetic circuits in...
www.nature.com
January 13, 2025 at 10:55 AM
Are you looking looking to engineer chemical production in batch cultures? In our recent paper with
Ahmad Mannan we show show to design genetic circuits to enhance productivity!
Link: www.nature.com/articles/s41...
Ahmad Mannan we show show to design genetic circuits to enhance productivity!
Link: www.nature.com/articles/s41...
Reposted by Alexander Darlington
Really happy to contribute to this fantastic work led by Harman Mehta in collaboration with Rodrigo Ledesma and
@gbstan.bsky.social!! Harman demonstrates that a microbial biosynthetic pathway can be more efficient if divided between two strains 👏🎉🎊 www.biorxiv.org/content/10.1...
@gbstan.bsky.social!! Harman demonstrates that a microbial biosynthetic pathway can be more efficient if divided between two strains 👏🎉🎊 www.biorxiv.org/content/10.1...
www.biorxiv.org
January 11, 2025 at 9:44 AM
Really happy to contribute to this fantastic work led by Harman Mehta in collaboration with Rodrigo Ledesma and
@gbstan.bsky.social!! Harman demonstrates that a microbial biosynthetic pathway can be more efficient if divided between two strains 👏🎉🎊 www.biorxiv.org/content/10.1...
@gbstan.bsky.social!! Harman demonstrates that a microbial biosynthetic pathway can be more efficient if divided between two strains 👏🎉🎊 www.biorxiv.org/content/10.1...
Are you heading to Synthetic Biology UK? #BiochemEvent #SBUK2024 Unfortunately I am teaching but you can check out three posters from the group! Go and say hi!
November 26, 2024 at 1:46 PM
Are you heading to Synthetic Biology UK? #BiochemEvent #SBUK2024 Unfortunately I am teaching but you can check out three posters from the group! Go and say hi!
Reposted by Alexander Darlington
4 PhD positions available in my lab. All membranes / biotech focussed with interdisciplinary friends and industry.
www.linkedin.com/posts/alan-g...
www.linkedin.com/posts/alan-g...
Alan Goddard on LinkedIn: #biotechnology #biotech #phd #aston #industry #microbes #membranes
4 PhDs available in my lab!
1. Midlands Integrative Biosciences Training Partnership
https://lnkd.in/etB6FMqC
2. Aston Institute for Membrane…
www.linkedin.com
November 22, 2024 at 8:55 AM
4 PhD positions available in my lab. All membranes / biotech focussed with interdisciplinary friends and industry.
www.linkedin.com/posts/alan-g...
www.linkedin.com/posts/alan-g...
What happens if you delete the resource-expensive flagella? Published today doi.org/10.1111/1751-7…, Juhyun Kim’s group shows such deletions can create a flexible P putida cell factory!
https://doi.org/10.1111/1751-7…
November 21, 2024 at 11:10 PM
What happens if you delete the resource-expensive flagella? Published today doi.org/10.1111/1751-7…, Juhyun Kim’s group shows such deletions can create a flexible P putida cell factory!
Reposted by Alexander Darlington
Risk-averse optimization of genetic circuits under uncertainty
doi.org/10.1101/2024...
doi.org/10.1101/2024...
November 15, 2024 at 6:20 PM
Risk-averse optimization of genetic circuits under uncertainty
doi.org/10.1101/2024...
doi.org/10.1101/2024...