Patricia Ramos
@apramos.bsky.social
Dev Biologist, postdoc @BarrigaLab_@PolDresden. Postdoc
@NordenLab, MSCA fellow_optic cup morphogenesis, Phd @michalis_averof_parhyale eye evo-devo. #morphogenesis #evo_devo #imaging #image_analysis
@NordenLab, MSCA fellow_optic cup morphogenesis, Phd @michalis_averof_parhyale eye evo-devo. #morphogenesis #evo_devo #imaging #image_analysis
Finally, we disrupted apical patterned behaviors experimentally. The optic cup completely failed to start the invagination! (side note, the phenotype was so striking that I thought the microscope had crashed while imaging)
September 1, 2025 at 9:22 PM
Finally, we disrupted apical patterned behaviors experimentally. The optic cup completely failed to start the invagination! (side note, the phenotype was so striking that I thought the microscope had crashed while imaging)
But the surprise came from the apical surfaces. They undergo shape transitions before invagination starts. Could they be driving the process?
September 1, 2025 at 9:22 PM
But the surprise came from the apical surfaces. They undergo shape transitions before invagination starts. Could they be driving the process?
Separating the basal surface of the two epithelia (NE and RPE), we saw that they change their shape at the same time!
September 1, 2025 at 9:22 PM
Separating the basal surface of the two epithelia (NE and RPE), we saw that they change their shape at the same time!
We followed 3D shape changes of the forming optic cup, by tracking the basal surface
September 1, 2025 at 9:22 PM
We followed 3D shape changes of the forming optic cup, by tracking the basal surface
We used the Optic Cup formation as a system. The shape transition from a flat vesicle to an hemispheric eye precursor is just mesmerizing
September 1, 2025 at 9:22 PM
We used the Optic Cup formation as a system. The shape transition from a flat vesicle to an hemispheric eye precursor is just mesmerizing