Thank you so much!

Thanks Adrienne!

Thank you! and will do.

Thank you Jörg! I was so inspired by your work over the years.

This was a great collaboration with Dr. Paola Bardetti and Dr. Rico Rojas at NYU. With their help, we provide evidence that c-di-AMP functions to control the cytoplasmic turgor pressure. The c-di-AMP mediated reduction in turgor protects cells from lysis.

In short, there is: the c-di-AMP cyclase/regulator complex CdaAR upregulates cyclic-di-AMP in response to defects in cell wall synthesis. Similar to other envelope stress response systems in B. subtills, the cyclase regulator CdaR uses an intrinsically disordered region to sense cell wall defects.

c-di-AMP has long been implicated in resistance to cell wall targeting antibiotics. We hypothesized that there could be a regulatory connection between the cell envelope and c-di-AMP levels.