🫁We also found that sleep-disordered breathing and precuneus atrophy may help flag patients at higher risk, offering potential guidance for more targeted screening. 🧵5/5

Our observations indicate that atypical spike morphologies in AD may fall outside current diagnostic criteria designed for primary epilepsy. This highlights the need for a methodological consensus tailored to Alzheimer’s pathology. 🧵4/5

💤Here, we used overnight video-EEG-PSG with extended temporal electrodes and a tailored clinical questionnaire to study this comorbidity and push current detection limits. Epileptic events appeared in only 10% of patients, though several more reported symptoms suggestive of potential seizures. 🧵3/5

🧠Sleep-predominant epileptic activity is increasingly recognized as a possible disease-accelerating mechanism in Alzheimer’s disease - yet its prevalence, underlying mechanisms, and risk factors remain poorly understood. 🧵2/5