Atsuya Nishiyama
@anishiy.bsky.social
Reposted by Atsuya Nishiyama
TF binding is usually anticorrelated with DNA methylation, but there are very few studies that actually investigate why. This is really nice work from Jacques Drouin's lab showing PAX7 physically interacts with UHFR1, blocking DNMT1 recruitment @ircm.bsky.social www.science.org/doi/10.1126/...
Dual DNA demethylation mechanisms implement epigenetic memory driven by the pioneer factor PAX7
Pioneer factor PAX7 highjacks control of DNA methylation maintenance, leading to enhancer demethylation and epigenetic memory.
www.science.org
May 21, 2025 at 1:04 PM
TF binding is usually anticorrelated with DNA methylation, but there are very few studies that actually investigate why. This is really nice work from Jacques Drouin's lab showing PAX7 physically interacts with UHFR1, blocking DNMT1 recruitment @ircm.bsky.social www.science.org/doi/10.1126/...