Dana Davis Phf’nD
@angrybychoice.bsky.social
Micro prof interested in fungi, evolution, environmental adaptation.
Reposted by Dana Davis Phf’nD
Most definitely!
And we’ve got a new curriculum that addresses AI specifically:
And we’ve got a new curriculum that addresses AI specifically:
Modern-Day Oracles or Bullshit Machines: Introduction
A free online humanities course about how to learn and work and thrive in an AI world.
Thebullshitmachines.com
December 7, 2025 at 5:07 PM
Most definitely!
And we’ve got a new curriculum that addresses AI specifically:
And we’ve got a new curriculum that addresses AI specifically:
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December 8, 2025 at 1:50 PM
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Who needs yellow
Reposted by Dana Davis Phf’nD
Flagellar length control in Chlamydomonas is a paradigm for organelle size regulation. In poster 155 at the CellBio2025 meeting Sunday Dec 7, Ximena Garcia Arceo uses Lithium, which increases intraflagellar transport, as a tool to probe how length-altering mutants work.
December 7, 2025 at 3:43 AM
Flagellar length control in Chlamydomonas is a paradigm for organelle size regulation. In poster 155 at the CellBio2025 meeting Sunday Dec 7, Ximena Garcia Arceo uses Lithium, which increases intraflagellar transport, as a tool to probe how length-altering mutants work.
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Well, I’m guessing I won’t be getting it in 1 anytime soon unless I change my starting word
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Well, I’m guessing I won’t be getting it in 1 anytime soon unless I change my starting word
December 6, 2025 at 11:59 AM
Wordle 1,631 2/6
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Well, I’m guessing I won’t be getting it in 1 anytime soon unless I change my starting word
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Well, I’m guessing I won’t be getting it in 1 anytime soon unless I change my starting word
Reposted by Dana Davis Phf’nD
"Our results enable us to reject mitochondrion-early scenarios of eukaryogenesis, instead supporting a complexified-archaean, late-mitochondrion sequence for the assembly of eukaryote characteristics"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Dated gene duplications elucidate the evolutionary assembly of eukaryotes - Nature
Analysis of eukaryotic gene sequences using a relaxed molecular clock methodology indicate that eukaryotes emerged 3.0–2.25 billion years ago as a result of mitochondrial endosymbiosis with complex ar...
www.nature.com
December 3, 2025 at 10:14 PM
"Our results enable us to reject mitochondrion-early scenarios of eukaryogenesis, instead supporting a complexified-archaean, late-mitochondrion sequence for the assembly of eukaryote characteristics"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Dana Davis Phf’nD
Thorholludottir, D. A. V., Hsu, S. K., Barghi, N., Mallard, F., Nolte, V., Schlotterer, C. (2025). Reduced Parallel Gene Expression Evolution With Increasing Genetic Divergence-A Hallmark of Polygenic Adaptation. Mol Ecol, 34(12):e17803 onlinelibrary.wiley.com/doi/10.1111/...
December 3, 2025 at 11:29 PM
Thorholludottir, D. A. V., Hsu, S. K., Barghi, N., Mallard, F., Nolte, V., Schlotterer, C. (2025). Reduced Parallel Gene Expression Evolution With Increasing Genetic Divergence-A Hallmark of Polygenic Adaptation. Mol Ecol, 34(12):e17803 onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Dana Davis Phf’nD
A recent shift in centromere size and DNA content in Podospora pseudocomata co-occurs with the loss of a fungal genome defense system https://www.biorxiv.org/content/10.64898/2025.12.02.690432v1
December 3, 2025 at 2:31 AM
A recent shift in centromere size and DNA content in Podospora pseudocomata co-occurs with the loss of a fungal genome defense system https://www.biorxiv.org/content/10.64898/2025.12.02.690432v1
Reposted by Dana Davis Phf’nD
www.embopress.org/doi/full/10....
Our latest now online at EMBO Journal. Read if you are interested in how epimutations mediate antifungal resistance & how this might result in heteroresistance in human & cereal crop fungal pathogens. Big Thx & congrats to Andreas Fellas, Pin Tong & Alison Pidoux
Our latest now online at EMBO Journal. Read if you are interested in how epimutations mediate antifungal resistance & how this might result in heteroresistance in human & cereal crop fungal pathogens. Big Thx & congrats to Andreas Fellas, Pin Tong & Alison Pidoux
Heterochromatin epimutations impose mitochondrial dysfunction to confer antifungal resistance | The EMBO Journal
imageimageHeterochromatin-island epimutations can provide resistance to caffeine and antifungal
drugs in the fission yeast Schizosaccharomyces pombe. This study reveals that some epimutations cause re...
www.embopress.org
December 1, 2025 at 3:44 PM
www.embopress.org/doi/full/10....
Our latest now online at EMBO Journal. Read if you are interested in how epimutations mediate antifungal resistance & how this might result in heteroresistance in human & cereal crop fungal pathogens. Big Thx & congrats to Andreas Fellas, Pin Tong & Alison Pidoux
Our latest now online at EMBO Journal. Read if you are interested in how epimutations mediate antifungal resistance & how this might result in heteroresistance in human & cereal crop fungal pathogens. Big Thx & congrats to Andreas Fellas, Pin Tong & Alison Pidoux
Reposted by Dana Davis Phf’nD
It’s #MeiofaunaMonday! “Meiofauna” are microbial eukaryotes with a body size <1 mm (these animals and protists are as small as specks of dust you might see on a glass coffee table). Almost all of the 38 major animal groups have at least some small-bodied meiofauna species.
December 1, 2025 at 3:16 PM
It’s #MeiofaunaMonday! “Meiofauna” are microbial eukaryotes with a body size <1 mm (these animals and protists are as small as specks of dust you might see on a glass coffee table). Almost all of the 38 major animal groups have at least some small-bodied meiofauna species.
Study section meets in late Jan. Two more months to hear my proposal didn’t meet the 30% bar.
December 2, 2025 at 12:55 PM
Study section meets in late Jan. Two more months to hear my proposal didn’t meet the 30% bar.
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A tree grows in Brooklyn
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November 29, 2025 at 3:09 PM
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Thanksgiving weekend for me, recovering from surgery (fairly minor) playing Hades and Death Stranding…so far
November 28, 2025 at 9:38 PM
Thanksgiving weekend for me, recovering from surgery (fairly minor) playing Hades and Death Stranding…so far
Amazing work first worked on in a ciliate, tetrahymena, that has two functionally distinct nuclei. One of these the macronucleus contains many fragmented copies of the genome and every fragmented piece has telomeres on both ends. This oddity of biology made it relatively easy to identify.
Biochemist Dr. Elizabeth Blackburn was born #OTD in 1948.
She shared the 2009 #Nobel Prize in Physiology or Medicine for the discovery of the enzyme telomerase & how chromosomes are protected by telomeres. This has 𝘮𝘰𝘯𝘶𝘮𝘦𝘯𝘵𝘢𝘭 implications for the fields of #aging and #cancer research. #WomenInSTEM
She shared the 2009 #Nobel Prize in Physiology or Medicine for the discovery of the enzyme telomerase & how chromosomes are protected by telomeres. This has 𝘮𝘰𝘯𝘶𝘮𝘦𝘯𝘵𝘢𝘭 implications for the fields of #aging and #cancer research. #WomenInSTEM
November 27, 2025 at 7:53 PM
Amazing work first worked on in a ciliate, tetrahymena, that has two functionally distinct nuclei. One of these the macronucleus contains many fragmented copies of the genome and every fragmented piece has telomeres on both ends. This oddity of biology made it relatively easy to identify.
Reposted by Dana Davis Phf’nD
Fun new preprint from the lab, headed up by two incredible undergraduate researchers: Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast. www.biorxiv.org/content/10.1...
Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast
The budding yeast, Saccharomyces cerevisiae, is the workhorse of the brewing industry. Brewers have domesticated a vast array of different strains with traits that complement the beers they wish to br...
www.biorxiv.org
November 26, 2025 at 8:18 PM
Fun new preprint from the lab, headed up by two incredible undergraduate researchers: Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast. www.biorxiv.org/content/10.1...
Reposted by Dana Davis Phf’nD
www.nature.com/articles/s41...
Progressive coevolution of the yeast centromere and kinetochore
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@helsenjana.bsky.social @gautamdey.bsky.social
Progressive coevolution of the yeast centromere and kinetochore
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@helsenjana.bsky.social @gautamdey.bsky.social
Progressive coevolution of the yeast centromere and kinetochore - Nature
Thousands of centromeres were identified and tracked across two major fungal clades, showing that new centromeres spread progressively and that the kinetochore acts as a filter to determine which new ...
www.nature.com
November 27, 2025 at 6:22 PM
www.nature.com/articles/s41...
Progressive coevolution of the yeast centromere and kinetochore
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@helsenjana.bsky.social @gautamdey.bsky.social
Progressive coevolution of the yeast centromere and kinetochore
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@helsenjana.bsky.social @gautamdey.bsky.social
Reposted by Dana Davis Phf’nD
📢 NEW GENOME ALERT
Latest study in #G3journal shows high-quality genomes of P. mongolica and P. schrenkiana, fungi species known for forest decomposition, identifying genes responsible for lignocellulose decomposition. buff.ly/DYuyTyr
Latest study in #G3journal shows high-quality genomes of P. mongolica and P. schrenkiana, fungi species known for forest decomposition, identifying genes responsible for lignocellulose decomposition. buff.ly/DYuyTyr
November 27, 2025 at 7:08 PM
📢 NEW GENOME ALERT
Latest study in #G3journal shows high-quality genomes of P. mongolica and P. schrenkiana, fungi species known for forest decomposition, identifying genes responsible for lignocellulose decomposition. buff.ly/DYuyTyr
Latest study in #G3journal shows high-quality genomes of P. mongolica and P. schrenkiana, fungi species known for forest decomposition, identifying genes responsible for lignocellulose decomposition. buff.ly/DYuyTyr
Reposted by Dana Davis Phf’nD
No matter how long I live after we get through this dark chapter, I will never get over the immorality, the amorality, the corruption, the criminality and the cruelty in service to one of the worst humans to ever walk the earth.
November 26, 2025 at 1:13 AM
No matter how long I live after we get through this dark chapter, I will never get over the immorality, the amorality, the corruption, the criminality and the cruelty in service to one of the worst humans to ever walk the earth.
Reposted by Dana Davis Phf’nD
New preprint with @pyjiang.bsky.social and @kelleyharris.bsky.social! The discovery and patterns of the underlying long-standing mild-effect mutator alleles in S. cerevisiae populations www.biorxiv.org/content/10.1...
The discovery and patterns of the underlying long-standing mild-effect mutator alleles in S. cerevisiae populations
Most mutations are neutral or deleterious, and mutator alleles that increase the mutation rate of an organism are considered rare and short-lived. Here, we report a genomic signature consistent with t...
www.biorxiv.org
November 25, 2025 at 3:12 PM
New preprint with @pyjiang.bsky.social and @kelleyharris.bsky.social! The discovery and patterns of the underlying long-standing mild-effect mutator alleles in S. cerevisiae populations www.biorxiv.org/content/10.1...
Reposted by Dana Davis Phf’nD
So happy to announce our new preprint, “A geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63°C (145°F) 🔥 - a new record for euk growth!
#protistsonsky 🧵
#protistsonsky 🧵
November 25, 2025 at 8:41 PM
So happy to announce our new preprint, “A geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63°C (145°F) 🔥 - a new record for euk growth!
#protistsonsky 🧵
#protistsonsky 🧵
Louisiana’s top health official, a critic of the COVID vaccine, will be CDC deputy - NPR
Louisiana one of the worst states, arguably worst, in the union for health. Kudos of being top official of the worst outcomes.
Another old white guy continually falling upwards.
Louisiana one of the worst states, arguably worst, in the union for health. Kudos of being top official of the worst outcomes.
Another old white guy continually falling upwards.
November 26, 2025 at 3:14 AM
Louisiana’s top health official, a critic of the COVID vaccine, will be CDC deputy - NPR
Louisiana one of the worst states, arguably worst, in the union for health. Kudos of being top official of the worst outcomes.
Another old white guy continually falling upwards.
Louisiana one of the worst states, arguably worst, in the union for health. Kudos of being top official of the worst outcomes.
Another old white guy continually falling upwards.
Reposted by Dana Davis Phf’nD
In this #Yeast review article, Jose Ribamar Ferreira-Junior, Vittoria de Lima Camandona & Mario H. Barros show how Saccharomyces cerevisiae can be used as a model to study the cellular processes underlying #neurodegenerative disorders and to test new drugs 💊
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
From Yeast to Therapeutics: Modeling Neurodegenerative Diseases in Saccharomyces cerevisiae
Yeast plasmids expressing human Aβ-42, α-syn, htt, and TDP-43. Their fate includes an equilibrium between the endocytic pathway and aggregates that potentially disrupt endocytosis, vesicular transpor...
onlinelibrary.wiley.com
November 25, 2025 at 10:49 AM
In this #Yeast review article, Jose Ribamar Ferreira-Junior, Vittoria de Lima Camandona & Mario H. Barros show how Saccharomyces cerevisiae can be used as a model to study the cellular processes underlying #neurodegenerative disorders and to test new drugs 💊
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
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November 25, 2025 at 12:16 PM
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November 22, 2025 at 5:01 PM
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Reposted by Dana Davis Phf’nD
“The one who does the work does the learning.”
― Terry Doyle
― Terry Doyle
Relying on ChatGPT to teach you about a topic leaves you with shallower knowledge than Googling and reading about it, according to new research that compared what more than 10,000 people knew after using one method or the other.
Shared by @gizmodo.com: buff.ly/yAAHtHq
Shared by @gizmodo.com: buff.ly/yAAHtHq
November 21, 2025 at 12:09 PM
“The one who does the work does the learning.”
― Terry Doyle
― Terry Doyle