Andy Stringer
@andystringer.bsky.social
Not everything that can be counted counts.
Not everything that counts can be counted. (WB Cameron, 1963)
@AndyStringer@twitter
Not everything that counts can be counted. (WB Cameron, 1963)
@AndyStringer@twitter
Reposted by Andy Stringer
Idiocracy was a documentary
February 21, 2025 at 5:43 PM
Idiocracy was a documentary
Just experienced a marvelous concert at RNCM. Philip Glass' Glassworks.
www.rncm.ac.uk/performance/...
www.rncm.ac.uk/performance/...
February 14, 2025 at 2:51 PM
Just experienced a marvelous concert at RNCM. Philip Glass' Glassworks.
www.rncm.ac.uk/performance/...
www.rncm.ac.uk/performance/...
Interesting new mouse model for #Parkinsons (PD). Overexpressing α-synuclein in the substantia nigra.
Chronic administration of c-Abi ingibitor PD180970 was neuroprotective (reduced DA neuron loss).
The progression might be a better model of PD than the sudden loss caused by 6-OHDA & MPTP models.
Chronic administration of c-Abi ingibitor PD180970 was neuroprotective (reduced DA neuron loss).
The progression might be a better model of PD than the sudden loss caused by 6-OHDA & MPTP models.
February 13, 2025 at 10:39 PM
Interesting new mouse model for #Parkinsons (PD). Overexpressing α-synuclein in the substantia nigra.
Chronic administration of c-Abi ingibitor PD180970 was neuroprotective (reduced DA neuron loss).
The progression might be a better model of PD than the sudden loss caused by 6-OHDA & MPTP models.
Chronic administration of c-Abi ingibitor PD180970 was neuroprotective (reduced DA neuron loss).
The progression might be a better model of PD than the sudden loss caused by 6-OHDA & MPTP models.
Some good new amongst the Trumpian dystopia pervading the world at the moment.
Not sure when we get this in the UK The 1st in a new class of analgesics: Sodium (NaV1.8) Channel blocker, suzetrigine.
I think at £12.50 per capsule it will remain a bit niche for a while.
www.bbc.co.uk/news/article...
Not sure when we get this in the UK The 1st in a new class of analgesics: Sodium (NaV1.8) Channel blocker, suzetrigine.
I think at £12.50 per capsule it will remain a bit niche for a while.
www.bbc.co.uk/news/article...
Vertex: New non-opioid painkiller Journavx approved by US FDA
New drug suzetrigine, known by its brand name Journavx, has been approved to treat moderate to severe pain.
www.bbc.co.uk
January 31, 2025 at 8:16 AM
Some good new amongst the Trumpian dystopia pervading the world at the moment.
Not sure when we get this in the UK The 1st in a new class of analgesics: Sodium (NaV1.8) Channel blocker, suzetrigine.
I think at £12.50 per capsule it will remain a bit niche for a while.
www.bbc.co.uk/news/article...
Not sure when we get this in the UK The 1st in a new class of analgesics: Sodium (NaV1.8) Channel blocker, suzetrigine.
I think at £12.50 per capsule it will remain a bit niche for a while.
www.bbc.co.uk/news/article...
Reposted by Andy Stringer
Reposted by Andy Stringer
THIS IS HUGE! Researchers at Stanford Medicine have devised an influenza vaccine that prompts immunity to ALL four major flu subtypes AND shows potential against bird flu, indicating a significant advancement in flu prevention and a potential increase in vaccine efficacy. Let’s talk about that! 🧪🧵⬇️
January 2, 2025 at 5:00 PM
THIS IS HUGE! Researchers at Stanford Medicine have devised an influenza vaccine that prompts immunity to ALL four major flu subtypes AND shows potential against bird flu, indicating a significant advancement in flu prevention and a potential increase in vaccine efficacy. Let’s talk about that! 🧪🧵⬇️
Reposted by Andy Stringer
A clear, well-referenced and (to my mind) sound summary of what happens during propofol anaesthesia. 👏
#biophysics #neuroscience #consciousness
#biophysics #neuroscience #consciousness
The Brain in the Operating Room: Understanding the Loss of Consciousness During General Anesthesia
www.greymattersjournalvc.org/issue-9-arti...
#neuroscience
www.greymattersjournalvc.org/issue-9-arti...
#neuroscience
The Brain in the Operating Room: Understanding the Loss of Consciousness During General Anesthesia — Grey Matters at Vassar College
Katerina Hristova Illustrations by Anna Bishop & Iris Li
www.greymattersjournalvc.org
January 3, 2025 at 9:13 AM
A clear, well-referenced and (to my mind) sound summary of what happens during propofol anaesthesia. 👏
#biophysics #neuroscience #consciousness
#biophysics #neuroscience #consciousness
Reposted by Andy Stringer
Reopening the Skipton-Colne rail line is a vital test of regional devolution, promising more than just economic growth for the North.
Reconnecting the North: the case for reopening the Skipton-Colne rail line
Reopening the Skipton-Colne rail line is a vital test of regional devolution, promising more than just economic growth for the North
yorkshirebylines.co.uk
December 28, 2024 at 8:18 AM
Reopening the Skipton-Colne rail line is a vital test of regional devolution, promising more than just economic growth for the North.
Great new Hikki song, "Electricity".
Especially:
"Fearing what we can’t comprehend
Falling into conspiracy theory traps
I’d like all of humanity to read the letter
That Einstein wrote to his daughter
Love is light, love is our essence"
www.youtube.com/watch?v=9Ef8...
Especially:
"Fearing what we can’t comprehend
Falling into conspiracy theory traps
I’d like all of humanity to read the letter
That Einstein wrote to his daughter
Love is light, love is our essence"
www.youtube.com/watch?v=9Ef8...
宇多田ヒカル『Electricity』
YouTube video by Hikaru Utada
www.youtube.com
December 13, 2024 at 10:10 AM
Great new Hikki song, "Electricity".
Especially:
"Fearing what we can’t comprehend
Falling into conspiracy theory traps
I’d like all of humanity to read the letter
That Einstein wrote to his daughter
Love is light, love is our essence"
www.youtube.com/watch?v=9Ef8...
Especially:
"Fearing what we can’t comprehend
Falling into conspiracy theory traps
I’d like all of humanity to read the letter
That Einstein wrote to his daughter
Love is light, love is our essence"
www.youtube.com/watch?v=9Ef8...
December 10, 2024 at 10:46 PM
Reposted by Andy Stringer
Gabapentin's Effect on Human Dorsal Root Ganglia: Donor-Specific Electrophysiological and Transcriptomic Profiles https://www.biorxiv.org/content/10.1101/2024.12.05.627067v1
December 10, 2024 at 3:15 PM
Gabapentin's Effect on Human Dorsal Root Ganglia: Donor-Specific Electrophysiological and Transcriptomic Profiles https://www.biorxiv.org/content/10.1101/2024.12.05.627067v1
Reposted by Andy Stringer
UK economic policy.
December 2, 2024 at 1:46 PM
UK economic policy.
Reposted by Andy Stringer
Pleasant smells: a privileged gateway to soothing autonomic responses and improving brain-body rhythm coupling https://www.biorxiv.org/content/10.1101/2024.11.29.625994v1
Pleasant smells: a privileged gateway to soothing autonomic responses and improving brain-body rhythm coupling https://www.biorxiv.org/content/10.1101/2024.11.29.625994v1
Aromatherapy commonly uses odors to improve well-being through their evocation of positive emotions.
www.biorxiv.org
November 30, 2024 at 9:16 PM
Pleasant smells: a privileged gateway to soothing autonomic responses and improving brain-body rhythm coupling https://www.biorxiv.org/content/10.1101/2024.11.29.625994v1
Reposted by Andy Stringer
Brilliant short film from Hannah King of forces news: ketamine therapy for trauma in Ukraine
youtu.be/wjt94xZw0dk?...
youtu.be/wjt94xZw0dk?...
Exclusive: Inside Ukrainian ketamine clinic treating soldiers suffering with PTSD
YouTube video by BFBS Forces News
youtu.be
November 29, 2024 at 8:31 AM
Brilliant short film from Hannah King of forces news: ketamine therapy for trauma in Ukraine
youtu.be/wjt94xZw0dk?...
youtu.be/wjt94xZw0dk?...
Reposted by Andy Stringer
This is cool, D2O (in place of H2O) as analgesic via TRPV1 permeation modulation
November 25, 2024 at 1:35 AM
This is cool, D2O (in place of H2O) as analgesic via TRPV1 permeation modulation
Reposted by Andy Stringer
Crazy stuff in PNAS
dental plaque bacterium 𝘊𝘰𝘳𝘺𝘯𝘦𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘶𝘮 𝘮𝘢𝘵𝘳𝘶𝘤𝘩𝘰𝘵𝘪𝘪 can divide into an unprecedented 14 daughter cells at once—then each daughter cell starts growing immediately in a rare process called multiple fission, achieving 0.5 mm per day of expansion
www.snexplores.org/article/bact...
dental plaque bacterium 𝘊𝘰𝘳𝘺𝘯𝘦𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘶𝘮 𝘮𝘢𝘵𝘳𝘶𝘤𝘩𝘰𝘵𝘪𝘪 can divide into an unprecedented 14 daughter cells at once—then each daughter cell starts growing immediately in a rare process called multiple fission, achieving 0.5 mm per day of expansion
www.snexplores.org/article/bact...
These mouth bacteria use a new type of cell division to make 14 cells at once
The newfound strategy seen in C. matruchotii might help oral bacteria recover lost territory after each eviction by toothbrushing.
www.snexplores.org
November 22, 2024 at 9:54 PM
Crazy stuff in PNAS
dental plaque bacterium 𝘊𝘰𝘳𝘺𝘯𝘦𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘶𝘮 𝘮𝘢𝘵𝘳𝘶𝘤𝘩𝘰𝘵𝘪𝘪 can divide into an unprecedented 14 daughter cells at once—then each daughter cell starts growing immediately in a rare process called multiple fission, achieving 0.5 mm per day of expansion
www.snexplores.org/article/bact...
dental plaque bacterium 𝘊𝘰𝘳𝘺𝘯𝘦𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘶𝘮 𝘮𝘢𝘵𝘳𝘶𝘤𝘩𝘰𝘵𝘪𝘪 can divide into an unprecedented 14 daughter cells at once—then each daughter cell starts growing immediately in a rare process called multiple fission, achieving 0.5 mm per day of expansion
www.snexplores.org/article/bact...
Reposted by Andy Stringer
Can we design allosteric modulators that change a GPCR's preferred G protein? Yes!💥
BAMs at the GPCR-transducer interface change G protein subtype selectivity in predictable ways, enabling rational drug design.
The lab's 1st preprint! Check it out! 🧪💊🧠🟦https://doi.org/10.1101/2024.11.20.624209
🧵👇
BAMs at the GPCR-transducer interface change G protein subtype selectivity in predictable ways, enabling rational drug design.
The lab's 1st preprint! Check it out! 🧪💊🧠🟦https://doi.org/10.1101/2024.11.20.624209
🧵👇
Design of allosteric modulators that change GPCR G protein subtype selectivity
G protein-coupled receptors (GPCRs), the largest family of drug targets, can signal through 16 subtypes of Gα proteins. Biased compounds that selectively activate therapy-relevant pathways promise to ...
doi.org
November 22, 2024 at 4:09 PM
Can we design allosteric modulators that change a GPCR's preferred G protein? Yes!💥
BAMs at the GPCR-transducer interface change G protein subtype selectivity in predictable ways, enabling rational drug design.
The lab's 1st preprint! Check it out! 🧪💊🧠🟦https://doi.org/10.1101/2024.11.20.624209
🧵👇
BAMs at the GPCR-transducer interface change G protein subtype selectivity in predictable ways, enabling rational drug design.
The lab's 1st preprint! Check it out! 🧪💊🧠🟦https://doi.org/10.1101/2024.11.20.624209
🧵👇
Good review of Na+, K+, Ca2+, Cl- channelopathies:
journals.physiology.org/doi/full/10....
journals.physiology.org/doi/full/10....
December 14, 2023 at 8:26 AM
Good review of Na+, K+, Ca2+, Cl- channelopathies:
journals.physiology.org/doi/full/10....
journals.physiology.org/doi/full/10....
Great review of "The T‑type calcium channelosome" by Norbert Weiss and Gerald Zamponi.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
December 1, 2023 at 8:08 AM
Great review of "The T‑type calcium channelosome" by Norbert Weiss and Gerald Zamponi.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
It needs stopping!
Duly signed.
(Not sure how much effect that will have though 🤔.)
Duly signed.
(Not sure how much effect that will have though 🤔.)
I don't want Palantir anywhere near our NHS data...
...and neither should you.
Share everywhere and sign below.
👇👇
...and neither should you.
Share everywhere and sign below.
👇👇
UK Health Secretary Steve Barclay: Stop Palantir’s NHS data takeover
Urgent - the Palantir NHS data deal is a huge threat to the NHS, but it still hasn’t been signed, and there are reports that the government is now wavering. This is our chance to get it dropped - si...
www.foxglove.org.uk
November 9, 2023 at 8:35 AM
It needs stopping!
Duly signed.
(Not sure how much effect that will have though 🤔.)
Duly signed.
(Not sure how much effect that will have though 🤔.)
Reposted by Andy Stringer
Looks like another great paper from
Rajesh Khanna's group, great stuff!Intranasal CRMP2-Ubc9 inhibitor regulates NaV1.7 to alleviate trigeminal neuropathic pain #neuroscience #pain Intranasal CRMP2-Ubc9 inhibitor regulates NaV1.7 to... : PAIN journals.lww.com/pain/fulltex... #neuroscience
Rajesh Khanna's group, great stuff!Intranasal CRMP2-Ubc9 inhibitor regulates NaV1.7 to alleviate trigeminal neuropathic pain #neuroscience #pain Intranasal CRMP2-Ubc9 inhibitor regulates NaV1.7 to... : PAIN journals.lww.com/pain/fulltex... #neuroscience
September 28, 2023 at 6:59 AM
Looks like another great paper from
Rajesh Khanna's group, great stuff!Intranasal CRMP2-Ubc9 inhibitor regulates NaV1.7 to alleviate trigeminal neuropathic pain #neuroscience #pain Intranasal CRMP2-Ubc9 inhibitor regulates NaV1.7 to... : PAIN journals.lww.com/pain/fulltex... #neuroscience
Rajesh Khanna's group, great stuff!Intranasal CRMP2-Ubc9 inhibitor regulates NaV1.7 to alleviate trigeminal neuropathic pain #neuroscience #pain Intranasal CRMP2-Ubc9 inhibitor regulates NaV1.7 to... : PAIN journals.lww.com/pain/fulltex... #neuroscience