Andrew Stern
@andrewmstern.bsky.social
Neurologist and Alzheimer disease scientist at Brigham and Women’s Hospital. My lab studies beta-amyloid aggregates as they occur in human brain. Also TDP-43 biomarkers. Associate PD for research at MGB neurology residency program. sternlab.bwh.harvard.edu
We are looking to hire a postdoc to take this and other TDP-43 assay development forward! Please re-post!
October 24, 2025 at 8:58 PM
We are looking to hire a postdoc to take this and other TDP-43 assay development forward! Please re-post!
Thanks guys. To be clear, I still favor that antibody directly binding to CAA could be a cause of ARIA. We just found that the difference in ARIA-E between lec and adu can’t be fully explained by differences in CAA preference.
May 22, 2025 at 12:51 PM
Thanks guys. To be clear, I still favor that antibody directly binding to CAA could be a cause of ARIA. We just found that the difference in ARIA-E between lec and adu can’t be fully explained by differences in CAA preference.
Reposted by Andrew Stern
Reposted by Andrew Stern
Zach Augur will be presenting a poster during Shift 1 on April 2nd and 3rd titled "BAG3 IN ALZHEIMER’S DISEASE AND ITS IMPACT ON ASTROCYTE FUNCTION AND DISEASE PROGRESSION"
March 28, 2025 at 10:13 PM
Zach Augur will be presenting a poster during Shift 1 on April 2nd and 3rd titled "BAG3 IN ALZHEIMER’S DISEASE AND ITS IMPACT ON ASTROCYTE FUNCTION AND DISEASE PROGRESSION"
Reposted by Andrew Stern
@gizemterzioglu.bsky.social will be presenting at the Microglia Symposium on the afternoon of April 4th! Her talk is titled "INPP5D/SHIP1 REGULATES MICROGLIA FUNCTION AND INFLAMMATORY RESPONSE IN ALZHEIMER'S DISEASE"
March 28, 2025 at 10:27 PM
@gizemterzioglu.bsky.social will be presenting at the Microglia Symposium on the afternoon of April 4th! Her talk is titled "INPP5D/SHIP1 REGULATES MICROGLIA FUNCTION AND INFLAMMATORY RESPONSE IN ALZHEIMER'S DISEASE"
Yes SEC followed by several techniques like ELISA, Western blot, EM, etc.
March 15, 2025 at 12:46 AM
Yes SEC followed by several techniques like ELISA, Western blot, EM, etc.
It’s good to be skeptical! I agree - I don’t think there’s a distinct atomic structure of oligomers/protofibrils as distinct from fibrils found in plaques. But there are reasons “they” said these things.
March 14, 2025 at 5:03 PM
It’s good to be skeptical! I agree - I don’t think there’s a distinct atomic structure of oligomers/protofibrils as distinct from fibrils found in plaques. But there are reasons “they” said these things.
We’re still working on it! We have some interesting SEC data to share with you. I think Dennis or our postdoc Youqi will present some at AD/PD if you’ll be there (I won’t).
March 14, 2025 at 4:41 PM
We’re still working on it! We have some interesting SEC data to share with you. I think Dennis or our postdoc Youqi will present some at AD/PD if you’ll be there (I won’t).
The homogenization, centrifuge speeds, detection methods, etc always vary paper to paper but the finding is reproducible. See also eg pubmed.ncbi.nlm.nih.gov/23225543/
Amyloid-β oligomerization in Alzheimer dementia versus high-pathology controls - PubMed
The results raise the intriguing hypothesis that the linkage between plaques and oligomers may be a key pathophysiological event underlying dementia of the Alzheimer type. This Aβ oligomer assay may b...
pubmed.ncbi.nlm.nih.gov
March 14, 2025 at 4:40 PM
The homogenization, centrifuge speeds, detection methods, etc always vary paper to paper but the finding is reproducible. See also eg pubmed.ncbi.nlm.nih.gov/23225543/