Andrew Stern
@andrewmstern.bsky.social
Neurologist and Alzheimer disease scientist at Brigham and Women’s Hospital. My lab studies beta-amyloid aggregates as they occur in human brain. Also TDP-43 biomarkers. Associate PD for research at MGB neurology residency program. sternlab.bwh.harvard.edu
Pinned
Andrew Stern
@andrewmstern.bsky.social
· Jul 25
My lab is hiring a postdoc to work on new TDP-43 biomarkers! Please get in touch and re-post!
Any cryoEM folks know what these strange zebra-stripe particles are in a prep from human brain?
October 31, 2025 at 2:00 PM
Any cryoEM folks know what these strange zebra-stripe particles are in a prep from human brain?
Reposted by Andrew Stern
Our study “Genetic and proteomic analysis identifies BAG3 as an amyloid‑responsive regulator of neuronal proteostasis" was published in Acta Neuropathologica this week! Congratulations to lead author Zach Augur, who will be defending his thesis later this week!!
link.springer.com/epdf/10.1007...
link.springer.com/epdf/10.1007...
Genetic and proteomic analysis identifies BAG3 as an amyloid-responsive regulator of neuronal proteostasis
link.springer.com
October 15, 2025 at 2:08 PM
Our study “Genetic and proteomic analysis identifies BAG3 as an amyloid‑responsive regulator of neuronal proteostasis" was published in Acta Neuropathologica this week! Congratulations to lead author Zach Augur, who will be defending his thesis later this week!!
link.springer.com/epdf/10.1007...
link.springer.com/epdf/10.1007...
Working with David Walt’s lab, here is a new tool we hope to develop into a diagnostic test for TDP-43 pathology, something we desperately need in cognitive neurology. www.medrxiv.org/content/10.1...
Digital seed amplification assay for TDP-43 aggregate quantification in CSF
INTRODUCTION Dementia is commonly caused by underlying pathologies driven by misfolded protein aggregates. Although dementia subtypes have distinct mechanisms, overlapping symptoms make diagnosis with...
www.medrxiv.org
October 16, 2025 at 11:14 AM
Working with David Walt’s lab, here is a new tool we hope to develop into a diagnostic test for TDP-43 pathology, something we desperately need in cognitive neurology. www.medrxiv.org/content/10.1...
Some thoughts on personalized medicine. open.substack.com/pub/andrewms...
On exactitude in single-molecule omics of the human body
Toward truly personalized medicine
open.substack.com
October 4, 2025 at 2:00 PM
Some thoughts on personalized medicine. open.substack.com/pub/andrewms...
Some poorly conceived thoughts on modern science. open.substack.com/pub/andrewms...
Simultanagnosia and scientific paradigms
This week, in our case rounds, one of our clinical fellows presented a classic case of posterior cortical atrophy, an atypical presentation of Alzheimer disease.
open.substack.com
September 5, 2025 at 12:53 AM
Some poorly conceived thoughts on modern science. open.substack.com/pub/andrewms...
Reposted by Andrew Stern
My lab is hiring a postdoc to work on new TDP-43 biomarkers! Please get in touch and re-post!
July 25, 2025 at 3:18 PM
My lab is hiring a postdoc to work on new TDP-43 biomarkers! Please get in touch and re-post!
BREAKING: Field makes inchwise progress over decades on intractable problem of dementia with interesting leads and blind alleys but smart people are doing their best and please don’t overinterpret their results because it takes a long time for a real breakthrough
www.bostonglobe.com/2025/08/06/m...
www.bostonglobe.com/2025/08/06/m...
New hope for Alzheimer’s: Groundbreaking Harvard study finds lithium reverses brain aging - The Boston Globe
The research suggests a new approach to preventing and treating the mind-robbing disease.
www.bostonglobe.com
August 7, 2025 at 2:19 PM
BREAKING: Field makes inchwise progress over decades on intractable problem of dementia with interesting leads and blind alleys but smart people are doing their best and please don’t overinterpret their results because it takes a long time for a real breakthrough
www.bostonglobe.com/2025/08/06/m...
www.bostonglobe.com/2025/08/06/m...
Reposted by Andrew Stern
First highlight...
Senator Capito started of the discussion saying that the bill contains AN INCREASE for NIH.
The details are not available, but the bill will be released ofter the hearing.
This is not a done-deal, but it does show where the Senate is on a bipartisan basis.
Senator Capito started of the discussion saying that the bill contains AN INCREASE for NIH.
The details are not available, but the bill will be released ofter the hearing.
This is not a done-deal, but it does show where the Senate is on a bipartisan basis.
July 31, 2025 at 4:12 PM
First highlight...
Senator Capito started of the discussion saying that the bill contains AN INCREASE for NIH.
The details are not available, but the bill will be released ofter the hearing.
This is not a done-deal, but it does show where the Senate is on a bipartisan basis.
Senator Capito started of the discussion saying that the bill contains AN INCREASE for NIH.
The details are not available, but the bill will be released ofter the hearing.
This is not a done-deal, but it does show where the Senate is on a bipartisan basis.
My lab is hiring a postdoc to work on new TDP-43 biomarkers! Please get in touch and re-post!
July 25, 2025 at 3:18 PM
My lab is hiring a postdoc to work on new TDP-43 biomarkers! Please get in touch and re-post!
Reposted by Andrew Stern
New TYP lab publication led by PhD student @alexlish.bsky.social out today in @cp-cellreports.bsky.social! We present a reproducible neuron-astrocyte-microglia tri-culture model to better reproduce intercellular interactions in Alzheimer's disease. Read more here: www.cell.com/cell-reports...
Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures
Lish et al. present a co-culture system of iPSC-derived human microglia, astrocytes,
and neurons to investigate intercellular communication across different environmental
and genetic contexts. Transcr...
www.cell.com
June 5, 2025 at 12:49 AM
New TYP lab publication led by PhD student @alexlish.bsky.social out today in @cp-cellreports.bsky.social! We present a reproducible neuron-astrocyte-microglia tri-culture model to better reproduce intercellular interactions in Alzheimer's disease. Read more here: www.cell.com/cell-reports...
Well said!
I was invited to comment for AlzForum on GLP-1s and dementia.
GLP-1s show promise, but RCTs like GRADE have not demonstrated clear cognitive benefits. Observational studies may be confounded by socioeconomic factors and prescribing patterns.
Read the full comment: www.alzforum.org/papers/gluco...
GLP-1s show promise, but RCTs like GRADE have not demonstrated clear cognitive benefits. Observational studies may be confounded by socioeconomic factors and prescribing patterns.
Read the full comment: www.alzforum.org/papers/gluco...
Glucose-Lowering Medications, Glycemia, and Cognitive Outcomes: The GRADE Randomized Clinical Trial. | ALZFORUM
www.alzforum.org
May 27, 2025 at 11:49 PM
Well said!
We studied the binding of clinical antibodies to human brain extracts and found no evidence that lecanemab binds a more soluble population of Abeta than aducanumab or donanemab, nor that binding preferences to CAA vs plaque explained different ARIA rates. www.biorxiv.org/content/10.1...
Anti-amyloid antibody equilibrium binding to Aβ aggregates from human Alzheimer disease brain
Importance: Anti-amyloid immunotherapy is used to treat Alzheimer disease (AD) with moderate benefits and potentially serious side effects due to amyloid related imaging abnormality with effusions/ede...
www.biorxiv.org
May 21, 2025 at 11:27 PM
We studied the binding of clinical antibodies to human brain extracts and found no evidence that lecanemab binds a more soluble population of Abeta than aducanumab or donanemab, nor that binding preferences to CAA vs plaque explained different ARIA rates. www.biorxiv.org/content/10.1...
Reposted by Andrew Stern
Thrilled to share my first first-author paper is out
@cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes.
Read here www.sciencedirect.com/science/arti...
@cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes.
Read here www.sciencedirect.com/science/arti...
CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density
Genetic studies implicate clusterin (CLU) in the pathogenesis of Alzheimer’s disease (AD), yet its precise molecular impact remains unclear. Through u…
www.sciencedirect.com
April 30, 2025 at 3:51 PM
Thrilled to share my first first-author paper is out
@cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes.
Read here www.sciencedirect.com/science/arti...
@cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes.
Read here www.sciencedirect.com/science/arti...
Reposted by Andrew Stern
Reposted by Andrew Stern
Congratulations our newly-minted PhD candidate Olivia Pembridge on passing her PQE with flying colors today! Olivia will be using a wide array of iPSC and organoid models to study mechanisms of neurodevelopment!
April 11, 2025 at 11:50 PM
Congratulations our newly-minted PhD candidate Olivia Pembridge on passing her PQE with flying colors today! Olivia will be using a wide array of iPSC and organoid models to study mechanisms of neurodevelopment!
Reposted by Andrew Stern
If you're headed to #ADPD next week, be sure to stop by the TYP lab presentations by @gizemterzioglu.bsky.social and Zach Augur to learn about some of the amazing work the lab is doing!
March 28, 2025 at 10:13 PM
If you're headed to #ADPD next week, be sure to stop by the TYP lab presentations by @gizemterzioglu.bsky.social and Zach Augur to learn about some of the amazing work the lab is doing!
Reposted by Andrew Stern
Zach Augur will be presenting a poster during Shift 1 on April 2nd and 3rd titled "BAG3 IN ALZHEIMER’S DISEASE AND ITS IMPACT ON ASTROCYTE FUNCTION AND DISEASE PROGRESSION"
March 28, 2025 at 10:13 PM
Zach Augur will be presenting a poster during Shift 1 on April 2nd and 3rd titled "BAG3 IN ALZHEIMER’S DISEASE AND ITS IMPACT ON ASTROCYTE FUNCTION AND DISEASE PROGRESSION"
Reposted by Andrew Stern
@gizemterzioglu.bsky.social will be presenting at the Microglia Symposium on the afternoon of April 4th! Her talk is titled "INPP5D/SHIP1 REGULATES MICROGLIA FUNCTION AND INFLAMMATORY RESPONSE IN ALZHEIMER'S DISEASE"
March 28, 2025 at 10:27 PM
@gizemterzioglu.bsky.social will be presenting at the Microglia Symposium on the afternoon of April 4th! Her talk is titled "INPP5D/SHIP1 REGULATES MICROGLIA FUNCTION AND INFLAMMATORY RESPONSE IN ALZHEIMER'S DISEASE"
Reposted by Andrew Stern
A very thoughtful and sobering piece by Dr. Jason Karlawish.
"The problem is that the facts don't support Piller's message. It's sensational, and in my experience, it's causing harm."
How a Book Is Undermining Progress Against Alzheimer's www.medpagetoday.com/opinion/seco...
"The problem is that the facts don't support Piller's message. It's sensational, and in my experience, it's causing harm."
How a Book Is Undermining Progress Against Alzheimer's www.medpagetoday.com/opinion/seco...
March 5, 2025 at 11:24 PM
A very thoughtful and sobering piece by Dr. Jason Karlawish.
"The problem is that the facts don't support Piller's message. It's sensational, and in my experience, it's causing harm."
How a Book Is Undermining Progress Against Alzheimer's www.medpagetoday.com/opinion/seco...
"The problem is that the facts don't support Piller's message. It's sensational, and in my experience, it's causing harm."
How a Book Is Undermining Progress Against Alzheimer's www.medpagetoday.com/opinion/seco...
Reposted by Andrew Stern
It was distressing to see the skepticism about Alzheimer's disease research expressed at the Bhattahcharya hearing today.
This has been fueled by Charles Piller's sensationalized (NOT sensational) reporting and book.
1/n
This has been fueled by Charles Piller's sensationalized (NOT sensational) reporting and book.
1/n
March 5, 2025 at 9:44 PM
It was distressing to see the skepticism about Alzheimer's disease research expressed at the Bhattahcharya hearing today.
This has been fueled by Charles Piller's sensationalized (NOT sensational) reporting and book.
1/n
This has been fueled by Charles Piller's sensationalized (NOT sensational) reporting and book.
1/n
Reposted by Andrew Stern
Many Alzheimer’s researchers are also unhappy with Piller’s recent book and its negative characterization of the field, in which he inflates the significance of isolated fraud cases to argue that the entire field is corrupt. Here’s a rebuttal from my colleague Dennis Selkoe, published in STAT News:
There is no ‘amyloid cabal’ in Alzheimer’s research
“There exists no ‘amyloid cabal’” in Alzheimer’s research, neurologist Dennis Selkoe writes in response to Charles Piller’s “Doctored.”
www.statnews.com
March 4, 2025 at 10:50 PM
Many Alzheimer’s researchers are also unhappy with Piller’s recent book and its negative characterization of the field, in which he inflates the significance of isolated fraud cases to argue that the entire field is corrupt. Here’s a rebuttal from my colleague Dennis Selkoe, published in STAT News:
Reposted by Andrew Stern
@baldwin.senate.gov released a press release calling out the administration for damaging the Alzheimer's Disease Research Center network through it's screwing up NIH processes.
www.baldwin.senate.gov/news/press-r...
1/2
www.baldwin.senate.gov/news/press-r...
1/2
Baldwin Blasts Trump Administration for Stopping $65 Million for Alzheimer’s Disease Research | U.S. Senator Tammy Baldwin of Wisconsin
WASHINGTON, D.C. – Today, U.S. Senator Tammy Baldwin (D-WI), Ranking Member of the Senate...
www.baldwin.senate.gov
March 3, 2025 at 10:01 PM
@baldwin.senate.gov released a press release calling out the administration for damaging the Alzheimer's Disease Research Center network through it's screwing up NIH processes.
www.baldwin.senate.gov/news/press-r...
1/2
www.baldwin.senate.gov/news/press-r...
1/2
Reposted by Andrew Stern
If you want to learn about Charlie Piller's journalistic integrity, read this (long) thread.
bsky.app/profile/jere...
It is pretty telling...sensationalism without regard to getting the facts right.
bsky.app/profile/jere...
It is pretty telling...sensationalism without regard to getting the facts right.
Yea, but a lot of the important Alzheimer's papers are considered, in part, fraudulent (Charles Pillar's book "Doctored") There is a lot of tax payer money on research wasted on 1.) irreproducible results due to mistakes/fraud, 2.) deadwood faculty salaries, 3.) absurd journal subscription rates.
March 4, 2025 at 12:10 AM
If you want to learn about Charlie Piller's journalistic integrity, read this (long) thread.
bsky.app/profile/jere...
It is pretty telling...sensationalism without regard to getting the facts right.
bsky.app/profile/jere...
It is pretty telling...sensationalism without regard to getting the facts right.
Reposted by Andrew Stern
Congratulations to the newly minted PhD @alexlish.bsky.social on successfully defending her thesis today! Be on the lookout for all the amazing things to come from Dr. Lish!
February 28, 2025 at 10:16 PM
Congratulations to the newly minted PhD @alexlish.bsky.social on successfully defending her thesis today! Be on the lookout for all the amazing things to come from Dr. Lish!