A tecnologia existe, e as capacidades técnicas também. Precisamos incluir a metodologia em políticas públicas de vigilância. Para prevenir surtos, é essencial antecipar possíveis ameaças virais. E para isso, o sequenciamento de amplo espectro é uma arma fundamental. (4/4)

Ambas iniciativas usam metagenômica para ver o que os exames diagnósticos comuns não veem. Revelam coinfecções, possíveis escapes de diagnóstico, genomas virais jamais obtidos no Brasil, vírus emergentes, entre outras informações relevantes. (3/4)

Dois projetos do Instituto @todospelasaude.bsky.social mostram o caminho:
→ Revisa (Centros Sentinelas): detecta vírus em amostras sugestivas de infecções, porém negativas em exames tradicionais.
→ Vigilância de morcegos: revela potenciais vírus zoonóticos que circulam em áreas urbanas (2/4)

Learn more about these initiatives & how they foster the use of genomic data in health research: ga4gh.org | pathoplexus.org #GA4GH 4/4

Our session, hosted by the GA4GH Infectious Disease Community, focused on:

- Introducing Pathoplexus & Loculus.org to the GA4GH community
- Identifying synergies with GA4GH standards
- Outlining next steps for tech development & collaboration #GA4GH #DataSharing 3/4

Pathoplexus.org is a new pathogen genomic database powered by the open-source software Loculus. Our mission? To improve genomic data sharing for public health and research. #Pathoplexus 2/4

5/ It was a privilege to collaborate with experts committed to advancing genomics and One Health strategies. Strengthening genomic surveillance is vital for pandemic preparedness. Let’s keep pushing forward! 💪 #PublicHealth

4/ Sustainability is crucial! Combining metagenomics with cost-effective molecular tools like pan-viral PCRs & amplicon-based sequencing is essential for long-term surveillance success. Stronger intersectoral collaboration is also key. #PathogenDetection

3/ A major focus was a project, backed by ITpS & executed by the Division of Zoonosis Surveillance of São Paulo. In 2024 it used metagenomics to detect zoonotic viruses in urban areas, particularly in bats. #InfectiousDiseases

2/ The event brought together public health, animal health, and academic experts to explore ways to enhance health surveillance in Brazil. São Paulo’s experience with metagenomics was a key case study. #GenomicSurveillance

As a member of the Pathoplexus.org Executive Board, I joined discussions on the vital role of data sharing in strengthening global pathogen genomic surveillance.