Amit Das
@amit-das.bsky.social
I'm focused on the prevention of Alzheimer's disease in Down syndrome (DS-AD). I'm a younger sibling of an adult with Down syndrome, and I'll be keeping my feed up-to-date with the latest research on DS-AD that I find interesting.
Pinned
Amit Das
@amit-das.bsky.social
· Nov 26
His Amazing Self: a brother’s reflection on Down syndrome-associated Alzheimer’s Disease - LuMind IDSC Foundation
A personal reflection about an amazing brother with Down syndrome and the realities of Down syndrome-associated Alzheimer's Disease.
bit.ly
Being a sibling of someone with Down syndrome and working on ending Ds-associated Alzheimer's disease means walking a fine line between my role as brother and my role as professional. Read a perspective I wrote about this here: bit.ly/4ePeqN1 #disability #alzheimers #downsyndrome
First amyloid PET data I've seen so far in #DownSyndrome from Brazil (Mantovani et al) - found region-specific inflammation linked to amyloid. Important milestone for global equity in DS- #alzheimers research, exciting implications for future prevention studies that are truly global. bit.ly/3IiLjqQ
Neuroinflammation and amyloid load in different age groups of individuals with Down syndrome: A PET imaging study
INTRODUCTION Down syndrome (DS) is associated with early-onset Alzheimer's disease (AD). This study evaluated neuroinflammation and amyloid beta (Aβ) load in individuals with DS of different ages, u...
bit.ly
July 8, 2025 at 1:37 PM
First amyloid PET data I've seen so far in #DownSyndrome from Brazil (Mantovani et al) - found region-specific inflammation linked to amyloid. Important milestone for global equity in DS- #alzheimers research, exciting implications for future prevention studies that are truly global. bit.ly/3IiLjqQ
Reposted by Amit Das
As ICE ramps up immigration arrests in MA, it's started holding people in office building near the Burlington Mall.
The facility is not designed to be a detention facility. People are sleeping on concrete floors and lack access to sinks for handwashing
www.wbur.org/news/2025/06... @wbur.org
The facility is not designed to be a detention facility. People are sleeping on concrete floors and lack access to sinks for handwashing
www.wbur.org/news/2025/06... @wbur.org
ICE holding immigrants in 'abysmal' conditions at Burlington building, lawyers say
ICE is detaining immigrants in a Burlington office park building that wasn't designed as a holding facility. Lawyers say conditions there are "abysmal" and "unsanitary"
www.wbur.org
June 5, 2025 at 8:28 PM
As ICE ramps up immigration arrests in MA, it's started holding people in office building near the Burlington Mall.
The facility is not designed to be a detention facility. People are sleeping on concrete floors and lack access to sinks for handwashing
www.wbur.org/news/2025/06... @wbur.org
The facility is not designed to be a detention facility. People are sleeping on concrete floors and lack access to sinks for handwashing
www.wbur.org/news/2025/06... @wbur.org
This commentary from Maure-Blesa et al. captures the history of #downsyndrome -assoc. #alzheimers disease beautifully. It's been a long journey to get to this point, and there's still a long journey ahead as we push for prevention, but the reason to be hopeful has never been greater! bit.ly/3Hv6qG0
The history of Down syndrome-associated Alzheimer's disease; past, present, and future - PubMed
The landscape of Down syndrome-associated Alzheimer's disease (DSAD) research reflects decades of scientific endeavor and collaborative effort, charting a remarkable journey from initial observations ...
bit.ly
June 6, 2025 at 1:05 AM
This commentary from Maure-Blesa et al. captures the history of #downsyndrome -assoc. #alzheimers disease beautifully. It's been a long journey to get to this point, and there's still a long journey ahead as we push for prevention, but the reason to be hopeful has never been greater! bit.ly/3Hv6qG0
Reposted by Amit Das
This is a paradigm shift in the way we think about #alzheimers #AD and should be shared widely. #neuroskyence #neuroscience
please find below our latest paper on #AD
www.nature.com/articles/s41...
Individual bioenergetic capacity as a potential source of resilience to Alzheimer’s disease
www.nature.com/articles/s41...
Individual bioenergetic capacity as a potential source of resilience to Alzheimer’s disease
Individual bioenergetic capacity as a potential source of resilience to Alzheimer’s disease - Nature Communications
Bioenergetic capacity, the ability to maintain energy balance under stress, can be monitored using blood acylcarnitine profiles. Improving this capacity may slow Alzheimer’s disease progression.
www.nature.com
May 29, 2025 at 10:35 AM
This is a paradigm shift in the way we think about #alzheimers #AD and should be shared widely. #neuroskyence #neuroscience
Reposted by Amit Das
Bullying students and schools to provoke fear and silence dissent is how we trade democracy and freedom for authoritarianism. This will affect nearly a third of Harvard's students. We cannot be silent.
May 22, 2025 at 8:17 PM
Bullying students and schools to provoke fear and silence dissent is how we trade democracy and freedom for authoritarianism. This will affect nearly a third of Harvard's students. We cannot be silent.
Really interesting article from Witt, Shaffer, Torres, & Santoro about recruiting diverse groups of people with #downsyndrome for research. Key point: to achieve diversity, you have to intentionally seek out diversity. Science conducted in a vacuum will fail the generalizability test. bit.ly/3H0yNeI
Research Letter: Recruiting a Diverse Cohort in Genetics Research—Reflecting on Demographic Representation in a Down Syndrome Survey
Click on the article title to read more.
bit.ly
May 20, 2025 at 3:53 PM
Really interesting article from Witt, Shaffer, Torres, & Santoro about recruiting diverse groups of people with #downsyndrome for research. Key point: to achieve diversity, you have to intentionally seek out diversity. Science conducted in a vacuum will fail the generalizability test. bit.ly/3H0yNeI
Reposted by Amit Das
“Department of Government Efficiency.”
April 19, 2025 at 3:31 AM
“Department of Government Efficiency.”
Reposted by Amit Das
The head of our country’s government is in the early stages of consolidating total power. We must of course reject this, but that is not enough. We have to respond by creating a different and better kind of American politics than we have seen before.
April 17, 2025 at 6:21 PM
The head of our country’s government is in the early stages of consolidating total power. We must of course reject this, but that is not enough. We have to respond by creating a different and better kind of American politics than we have seen before.
Reposted by Amit Das
Hi, I write about science for STAT. We've been closely tracking the Trump Administration's cuts. And right now, we're speaking to folks whose graduate school/postdoc offers have been rescinded, to get a sense of the toll.
If anyone has interest, I'm reachable by DM or by Signal at JasonMast.05
If anyone has interest, I'm reachable by DM or by Signal at JasonMast.05
April 8, 2025 at 5:57 PM
Hi, I write about science for STAT. We've been closely tracking the Trump Administration's cuts. And right now, we're speaking to folks whose graduate school/postdoc offers have been rescinded, to get a sense of the toll.
If anyone has interest, I'm reachable by DM or by Signal at JasonMast.05
If anyone has interest, I'm reachable by DM or by Signal at JasonMast.05
Reposted by Amit Das
Rümeysa Öztürk should be at home in Somerville celebrating Ramadan with her friends and community.
March 28, 2025 at 8:09 PM
Rümeysa Öztürk should be at home in Somerville celebrating Ramadan with her friends and community.
Reposted by Amit Das
Trump Administration political operatives manipulating the scientific research process, picking and choosing which communities of patients will and will not get help. What could go wrong?
Trump officials will screen NIH funding opportunities
Staff at biomedical agency worry about political interference in setting priorities
www.science.org
March 28, 2025 at 2:23 PM
Trump Administration political operatives manipulating the scientific research process, picking and choosing which communities of patients will and will not get help. What could go wrong?
Want to understand the latest #downsyndrome #alzheimers clinical trials in a way that's accessible and easy to understand? Check out this family- and caregiver-oriented explainer that I helped my foundation put together! bit.ly/4ixNqnz
Understanding key differences among Alzheimer’s clinical trials in Down syndrome - LuMind IDSC Foundation
People with Down syndrome face a heightened risk of developing Alzheimer's disease (AD) due to their unique genetic makeup. While researchers have made
bit.ly
March 17, 2025 at 5:05 PM
Want to understand the latest #downsyndrome #alzheimers clinical trials in a way that's accessible and easy to understand? Check out this family- and caregiver-oriented explainer that I helped my foundation put together! bit.ly/4ixNqnz
Reposted by Amit Das
I just posted a new blog entry on Medium describing a couple of Kate's self-chosen strategies for dealing with the effects of her daily battle with Early Onset Alzheimer's #DownSyndrome #Alzheimers medium.com/@amykolbtuck...
Meeting Kate Where She Is
Unconventional Strategies for Addressing Mental Health Needs
medium.com
March 15, 2025 at 11:08 PM
I just posted a new blog entry on Medium describing a couple of Kate's self-chosen strategies for dealing with the effects of her daily battle with Early Onset Alzheimer's #DownSyndrome #Alzheimers medium.com/@amykolbtuck...
Reposted by Amit Das
The institutional Democratic Party is guided by an almost pathological level of conflict avoidance in almost every direction. “What can we do to make the least number of people mad?” is just a bankrupt way to operate.
March 13, 2025 at 10:23 PM
The institutional Democratic Party is guided by an almost pathological level of conflict avoidance in almost every direction. “What can we do to make the least number of people mad?” is just a bankrupt way to operate.
Reposted by Amit Das
“…dysfunction of the #blood–brain barrier and #inflammation in the central nervous system in individuals with #Down syndrome regression disorder (DSRD).” #DSRD could be an inflammatory condition affecting the brain. bit.ly/4bSbL51 [open access] bit.ly/4kQKCDA
Evidence of blood–brain barrier dysfunction and CSF immunoglobulin synthesis in Down Syndrome Regression Disorder
Objectives
This study sought to evaluate proteomic, metabolomic, and immune signatures in the cerebrospinal fluid of individuals with Down Syndrome Regression Disorder (DSRD).
Methods
A prospectiv.....
bit.ly
March 13, 2025 at 6:31 PM
“…dysfunction of the #blood–brain barrier and #inflammation in the central nervous system in individuals with #Down syndrome regression disorder (DSRD).” #DSRD could be an inflammatory condition affecting the brain. bit.ly/4bSbL51 [open access] bit.ly/4kQKCDA
Reposted by Amit Das
Astonishing in the breadth and depth of harm this proposal would inflict directly on 16 million people across every congressional district in the United States. Then add the ripple effects on the health of others in every community, the economic losses, the societal upheaval.
The Republican House Budget Resolution's Potential $880 Billion in Medicaid Cuts by Congressional District
The Republican House budget resolution would cost congressional districts an average of $2 billion each and could eliminate coverage for 15.9 million people.
www.americanprogress.org
February 26, 2025 at 1:16 AM
Astonishing in the breadth and depth of harm this proposal would inflict directly on 16 million people across every congressional district in the United States. Then add the ripple effects on the health of others in every community, the economic losses, the societal upheaval.
Reposted by Amit Das
This is not cutting "waste, fraud, and abuse." Pure and simple, this is undermining the science necessary to deliver better means of preventing, diagnosing, treating, and eventually curing diseases like #Alzheimers, #cancer, #diabetes, #stroke, #glaucoma, etc.
#dementia #mentalhealth #NIH #science
#dementia #mentalhealth #NIH #science
NIH Research Funding Drops $1B Under Trump Administration
TUESDAY, Feb. 18, 2025 (HealthDay News) -- Federal funding for medical research has dropped by roughly $1 billion this year, raising alarm among universities, m
www.healthday.com
February 18, 2025 at 8:17 PM
This is not cutting "waste, fraud, and abuse." Pure and simple, this is undermining the science necessary to deliver better means of preventing, diagnosing, treating, and eventually curing diseases like #Alzheimers, #cancer, #diabetes, #stroke, #glaucoma, etc.
#dementia #mentalhealth #NIH #science
#dementia #mentalhealth #NIH #science
Sometimes tragic things in nature reveal how we might improve lives. A new case report shows how extra copies of the APP gene can cause #Alzheimers, just like in #DownSyndrome. This strengthens the case for APP-targeting therapies to delay or prevent DS-associated Alzheimer’s. bit.ly/3X5QcYS (1/5)
A de novo, mosaic and complex chromosome 21 rearrangement causes APP triplication and familial autosomal dominant early onset Alzheimer disease - Scientific Reports
Scientific Reports - A de novo, mosaic and complex chromosome 21 rearrangement causes APP triplication and familial autosomal dominant early onset Alzheimer disease
bit.ly
February 18, 2025 at 5:02 PM
Sometimes tragic things in nature reveal how we might improve lives. A new case report shows how extra copies of the APP gene can cause #Alzheimers, just like in #DownSyndrome. This strengthens the case for APP-targeting therapies to delay or prevent DS-associated Alzheimer’s. bit.ly/3X5QcYS (1/5)
Trying to understand the #MAHA calculus on #Alzheimers: An "amyloid cabal" has taken over AD research. Per Alzforum, "black people with dementia are less likely to have amyloid". To move past the cabal's "agenda", we need more diverse Alzheimer's research. But that's... woke? 🤔 🤔 🤔 🤔 bit.ly/42V4EXe
Studying Diverse Populations May Require New Biomarkers | ALZFORUM
bit.ly
February 17, 2025 at 7:45 PM
Trying to understand the #MAHA calculus on #Alzheimers: An "amyloid cabal" has taken over AD research. Per Alzforum, "black people with dementia are less likely to have amyloid". To move past the cabal's "agenda", we need more diverse Alzheimer's research. But that's... woke? 🤔 🤔 🤔 🤔 bit.ly/42V4EXe
@petebuttigieg.bsky.social it's obvious that people want structural change in this country, and it's equally obvious that the changes happening now will hurt almost everyone. Why not define and popularize an agenda to structurally reform the country in a way that actually serves the people now?
February 17, 2025 at 4:13 PM
@petebuttigieg.bsky.social it's obvious that people want structural change in this country, and it's equally obvious that the changes happening now will hurt almost everyone. Why not define and popularize an agenda to structurally reform the country in a way that actually serves the people now?
Reposted by Amit Das
There is no ‘amyloid cabal’ in #Alzheimers research www.statnews.com/2025/02/14/a... via @statnews.com
#dementia #neuroscience #science #NeuroSky
#dementia #neuroscience #science #NeuroSky
There is no ‘amyloid cabal’ in Alzheimer’s research
“There exists no ‘amyloid cabal’” in Alzheimer’s research, neurologist Dennis Selkoe writes in response to Charles Piller’s “Doctored.”
www.statnews.com
February 14, 2025 at 7:41 PM
There is no ‘amyloid cabal’ in #Alzheimers research www.statnews.com/2025/02/14/a... via @statnews.com
#dementia #neuroscience #science #NeuroSky
#dementia #neuroscience #science #NeuroSky
So #RFKjr wants to fire people at the NIH involved in "amyloid plaque scandals that derailed #Alzheimers treatment for 20 years". The horror of a deeply uneducated man leading the #NIH aside, that amyloid research *is* the reason my brother with #downsyndrome has a chance to never get AD in his life
February 14, 2025 at 6:22 PM
So #RFKjr wants to fire people at the NIH involved in "amyloid plaque scandals that derailed #Alzheimers treatment for 20 years". The horror of a deeply uneducated man leading the #NIH aside, that amyloid research *is* the reason my brother with #downsyndrome has a chance to never get AD in his life
Reposted by Amit Das
Biopharma companies and CEOs are keeping their heads down at their own peril. They should speak up about what’s happening to the NIH and other science agencies before it’s too late.
Silence gives consent. And no one should consent to this.
Silence gives consent. And no one should consent to this.
Stand Up And Be Counted
www.science.org
February 12, 2025 at 4:45 PM
Biopharma companies and CEOs are keeping their heads down at their own peril. They should speak up about what’s happening to the NIH and other science agencies before it’s too late.
Silence gives consent. And no one should consent to this.
Silence gives consent. And no one should consent to this.