Bluma Lesch
@ambystoma22.bsky.social
Genetics faculty @ Yale: genetics, genomics, chromatin, reproduction, and evolution. Or really, just trying to see where the next result takes us.
Yes I did try that! It did not find the same gaps again (I guess we successfully addressed them), but did find new ones - maybe similar to some human reviewers. So some human judgment about the centrality of the gaps is still important.
October 16, 2025 at 12:53 PM
Yes I did try that! It did not find the same gaps again (I guess we successfully addressed them), but did find new ones - maybe similar to some human reviewers. So some human judgment about the centrality of the gaps is still important.
thanks! And totally agree - let's talk soon!
August 20, 2025 at 1:12 PM
thanks! And totally agree - let's talk soon!
This was also an exciting paper for us because we got to pre-review it even before submission with q.e.d’s AI qedscience.com. really helpful and improved a lot!
q.e.d Science
Critical Thinking AI for constructive criticism and science evaluation
qedscience.com
August 20, 2025 at 1:41 AM
This was also an exciting paper for us because we got to pre-review it even before submission with q.e.d’s AI qedscience.com. really helpful and improved a lot!
And please also check out this excellent complementary study from @namekawasatoshi.bsky.social. Using a slightly earlier KO model, they find that Smarca5 is also required in spermatogonia to prepare retinoic acid receptor binding sites: www.biorxiv.org/content/10.1...
The SMARCA5-DMRT1 Pioneer Complex Establishes Epigenetic Priming to Direct Male Germline Development
The establishment of cell type-specific chromatin landscapes is essential for cellular identity, but how these landscapes are generated remains poorly understood. Here, we demonstrate that the chromat...
www.biorxiv.org
August 3, 2025 at 2:21 AM
And please also check out this excellent complementary study from @namekawasatoshi.bsky.social. Using a slightly earlier KO model, they find that Smarca5 is also required in spermatogonia to prepare retinoic acid receptor binding sites: www.biorxiv.org/content/10.1...
Yes definitely! We looked at density very superficially (ATAC). Will be interesting to look more closely
August 2, 2025 at 12:28 PM
Yes definitely! We looked at density very superficially (ATAC). Will be interesting to look more closely