@alyssawinkler.bsky.social
Chemical and Computational Biologist
Lens on Cancer Epigenetics | UMich 〽️
Let's make "undruggable" obsolete
Lens on Cancer Epigenetics | UMich 〽️
Let's make "undruggable" obsolete
Reposted
Yesterday I attended the @standupforscience.bsky.social rally in DC. I appreciate the organizers and all the inspiring speakers; I feel some hope for U.S. the first time in a long time. Looking for how I can find this energy and get involved in Michigan!
March 9, 2025 at 3:12 AM
Yesterday I attended the @standupforscience.bsky.social rally in DC. I appreciate the organizers and all the inspiring speakers; I feel some hope for U.S. the first time in a long time. Looking for how I can find this energy and get involved in Michigan!
Reposted
Use this form to tell us how the new US administration is affecting your research, or suggest future coverage
https://go.nature.com/4aYn9Me
https://go.nature.com/4aYn9Me
Are the Trump team’s actions affecting your research? How to contact Nature
Use this form to share information with Nature’s news team, or to make suggestions for future coverage.
go.nature.com
February 15, 2025 at 12:26 PM
Use this form to tell us how the new US administration is affecting your research, or suggest future coverage
https://go.nature.com/4aYn9Me
https://go.nature.com/4aYn9Me
Reposted
NIH doesn’t just support infectious disease research—it drives breakthroughs in cancer, childhood diseases, heart disease, diabetes & more.
Thanks to NIH, we have:
💉 Cancer immunotherapy
❤️ Cholesterol-lowering statins
🩸 Insulin for diabetes
Investing in NIH = investing in life-saving discoveries.
Thanks to NIH, we have:
💉 Cancer immunotherapy
❤️ Cholesterol-lowering statins
🩸 Insulin for diabetes
Investing in NIH = investing in life-saving discoveries.
February 8, 2025 at 3:07 PM
NIH doesn’t just support infectious disease research—it drives breakthroughs in cancer, childhood diseases, heart disease, diabetes & more.
Thanks to NIH, we have:
💉 Cancer immunotherapy
❤️ Cholesterol-lowering statins
🩸 Insulin for diabetes
Investing in NIH = investing in life-saving discoveries.
Thanks to NIH, we have:
💉 Cancer immunotherapy
❤️ Cholesterol-lowering statins
🩸 Insulin for diabetes
Investing in NIH = investing in life-saving discoveries.
govdiff.com
Have to share this tool for transparency as shared online information changes.
Have to share this tool for transparency as shared online information changes.
GovDiff — Compare Government Websites Before and After Trump
govdiff.com
February 8, 2025 at 4:57 PM
govdiff.com
Have to share this tool for transparency as shared online information changes.
Have to share this tool for transparency as shared online information changes.
Strong agree. Peer review needs to retain some credibility here.
The US was considered a world leader in public health and research. With one repressive stroke that reputation risks being broken, argue @jocalynclark.bsky.social and @kamranabbasi.bsky.social www.bmj.com/content/388/...
February 6, 2025 at 11:49 PM
Strong agree. Peer review needs to retain some credibility here.
April 22nd 2025?
Trump’s first term birthed the March for Science. Where are the science activists now?
Trump's first term birthed the March for Science. Where are the science activists now?
Eight years after the first March for Science, there are no plans for another march at the dawn of a second Trump administration
buff.ly
February 5, 2025 at 11:22 PM
April 22nd 2025?
Reposted
Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X
https://go.nature.com/42tH8Ai
https://go.nature.com/42tH8Ai
Bluesky’s science takeover: 70% of Nature poll respondents use platform
Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X.
go.nature.com
January 24, 2025 at 11:52 AM
Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X
https://go.nature.com/42tH8Ai
https://go.nature.com/42tH8Ai
Excellent feature by Andy Extance in RSC on the history, function, and future of targeted protein degradation #TPD
The promise of drugs that send proteins to the shredder
www.chemistryworld.com/features/the...
www.chemistryworld.com/features/the...
The promise of drugs that send proteins to the shredder
Andy Extance charts how research into revolutionary targeted protein degradation therapies is moving from serendipity to strategic discovery
www.chemistryworld.com
January 14, 2025 at 3:16 PM
Excellent feature by Andy Extance in RSC on the history, function, and future of targeted protein degradation #TPD
Drug Company to Share Revenues With Indigenous People Who Donated Their Genes www.nytimes.com/2025/01/07/h...
Drug Company to Share Revenues With Indigenous People Who Donated Their Genes
Variant Bio, a small biotech company based in Seattle, is using genetic information from Indigenous people to develop drugs for obesity and diabetes.
www.nytimes.com
January 8, 2025 at 12:37 PM
Drug Company to Share Revenues With Indigenous People Who Donated Their Genes www.nytimes.com/2025/01/07/h...
Check out this paper and the models provided, will have seriously exciting applications for both preclinical and clinical researchers. Also gives a nice example about just how ML will be used to guide precision cancer diagnostics and therapy!
Thrilled to share the results in Cancer Cell of years of hard work to develop classifiers for all major TCGA cancer subtypes, enabling assessment of differential drug response among cancer subtypes in clinical trials. www.cell.com/cancer-cell/...
Classification of non-TCGA cancer samples to TCGA molecular subtypes using compact feature sets
Ellrott et al. provide a means to assign patient samples from clinical trials and other cancer genome studies to published TCGA molecular subtypes. Applying machine learning to data from five different molecular platforms for 8,791 TCGA tumor samples, they contribute a public resource of 737 top classifier models, which can form the foundation for clinical assay development.
www.cell.com
January 7, 2025 at 4:17 PM
Check out this paper and the models provided, will have seriously exciting applications for both preclinical and clinical researchers. Also gives a nice example about just how ML will be used to guide precision cancer diagnostics and therapy!
Check out the latest paper from the Cierpicki and Grembecka labs detailing the development of novel PRC1 inhibitors, which bind to the RING1B/BMI1 catalytic core to block H2AK119ub deposition. Excited to continue this story with characterization in AML and other leukemia models!
Development of PRC1 Inhibitors Employing Fragment-Based Approach and NMR-Guided Optimization
Polycomb Repressive Complex 1 (PRC1) is associated with transcriptional silencing, and its dysregulation plays an important role in various cancers. Well-characterized PRC1 inhibitors can facilitate t...
pubs.acs.org
January 3, 2025 at 5:42 PM
Check out the latest paper from the Cierpicki and Grembecka labs detailing the development of novel PRC1 inhibitors, which bind to the RING1B/BMI1 catalytic core to block H2AK119ub deposition. Excited to continue this story with characterization in AML and other leukemia models!
Reposted
While the risk of human-to-human transmission is still low, the pervasive reservoirs and appearance of new, concerning mutations or those identified as a threat science.org/doi/10.1126/...
demand a very high level of vigilance and preparedness
demand a very high level of vigilance and preparedness
A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors
In 2024, several human infections with highly pathogenic clade 2.3.4.4b bovine influenza H5N1 viruses in the United States raised concerns about their capability for bovine-to-human or even human-to-h...
science.org
December 31, 2024 at 11:44 PM
While the risk of human-to-human transmission is still low, the pervasive reservoirs and appearance of new, concerning mutations or those identified as a threat science.org/doi/10.1126/...
demand a very high level of vigilance and preparedness
demand a very high level of vigilance and preparedness
Reposted
There have been 5 articles in @nytimes.com recently on University of Michigan DEI quoting a few unhappy people.
In just 6 days the DEI office collected 1,000 testimonials from individuals impacted positively.
It should be required reading.
Too bad that perspective won’t be published.
In just 6 days the DEI office collected 1,000 testimonials from individuals impacted positively.
It should be required reading.
Too bad that perspective won’t be published.
December 19, 2024 at 2:16 AM
There have been 5 articles in @nytimes.com recently on University of Michigan DEI quoting a few unhappy people.
In just 6 days the DEI office collected 1,000 testimonials from individuals impacted positively.
It should be required reading.
Too bad that perspective won’t be published.
In just 6 days the DEI office collected 1,000 testimonials from individuals impacted positively.
It should be required reading.
Too bad that perspective won’t be published.